Information technology innovations: general diffusion patterns andits relationships to innovation characteristics

While many scholars of organizational innovations have examined characteristics of innovations such as relative advantage and complexity and how they facilitate the adoption of an innovation by organizations, others have used mathematical models to fit diffusion patterns. In this study, the authors attempt to integrate these two areas of inquiry and explore the possibilities to predict diffusion patterns based on characteristics of the innovation and the adopting entities. Based on a cross-sectional sample of 313 large American firms, 20 information technology (IT) innovations were examined and their diffusion patterns assessed with respect to models that espoused internal and external influence. The mixed influence model (Bass model) was chosen as a robust common representation for the set of diffusion patterns. However, the external influence as represented by the coefficient of innovation was found to be extremely small and the internal influence dominates for all innovations. The other two parameters of the model, the saturation level and the coefficient of imitation, which represents internal influence, were then used to perform a cluster analysis. Five clusters of technologies emerged, and the potential relationships between their innovation characteristics and diffusion patterns were explored. Rigorous examination of these potential relationships by future researchers may result in practical methods for predicting patterns of IT innovation diffusion based on innovation and technology characteristics     

The effect of the EAAEAE insert on the property of human metallothionein-3

MT3 shows apparently different properties and function fromMT1 even though they have 70% sequence homology. Possibly thetwo inserts, Thr5 and a negatively charged hexapeptide at position-55in MT3, play important roles. A series of MT3 variants aroundthe EAAEAE hexapeptide have been prepared by site-directed mutagenesisand their properties and reactivity towards pH, EDTA and DTNBhave been studied. Our detailed studies revealed that the EAAEAEinsert is essential to the property of MT3. It is the hexapeptideinsert, to some extent, making the MT3     

On/off cycling under multiple stresses

The authors describe an experiment, a model, and an analytic method for on/off vs. continuous policy evaluation. The methodology was developed and verified through experimentation. An experimental life-test of small DC motors was designed and performed; it involved on/off cycling vs. continuous operation under multiple stresses. A stress-factor reliability model based on the two-parameter Weibull proportional-hazards life distribution was fitted to the data. The analysis provides an estimate of the model parameters for the life distribution of the DC motors under two operating policies, while under multiple stresses. The characteristic life was related to the explanatory covariates: voltage, on/off cycling, and load. Due to the proportional hazards (common Weibull shape) nature of the model, acceleration factors were calculated to relate the stress levels. The reliability model was extended to develop a simple rule to aid in a decision between on/off cycling and continuous-run policies (to achieve higher reliability). The proposed model (with covariates) allows a much broader approach to reliability modeling than the usual Weibull model (without covariates) because it predicts the reliability under various environmental combinations     

点云模型的谱聚类分割

为了实现点云模型的有意义分割,提出一种基于谱聚类的分割算法.首先用图G表示点云模型,将分割问题转化为图切割问题;然后根据归一化的非对称Laplacian矩阵构造谱聚类空间;最后通过移除掉多余的特征向量,在一个更低维的空间中找到了分割问题的松弛解.文中还给出了该算法相关定理的证明,并通过实验验证了算法的正确性和有效性.     

光学遥感舰船目标识别方法

提出一种基于粗糙集理论和分层判别回归技术的光学遥感舰船目标识别方法。该方法首先提出新的光学遥感舰船识别特征———面积比编码,并与四类特征组合作为备选特征;然后基于粗糙集理论按同可区分度来计算各备选特征的重要性权值,自动选择出对正确识别贡献较大的特征组合;最后根据分层判别回归原理生成分类判决树来识别光学遥感舰船目标。实验结果表明,本文方法在识别精度和速度方面优于最近邻和支持向量机方法,且通用可行。     

基于B/S结构的大学生物品交换系统的设计与实现

大学生物品交换系统的宗旨在于不求回报无偿付出,在充分利用各种资源的同时,培养学生的勤俭节约意识和"低碳"意识,加强学生之间的联系与互动,促进节约型校园的发展,并且符合近年来一直倡导的"和谐校园"与"低碳校园"的要求。系统基于B/S结构,采用ASP作为系统开发语言,使用SQL SERVER 2000数据库作为整个交易系统的数据库服务器,提供数据存储和调用,实现基于B/S结构的大学生物品交换系统。     

SPI总线扩展PLC输出点数的设计与实现

针对PLC主模块可用输出点数少的缺点,提出了采用SPI总线和移位寄存器HC595相结合扩展PLC输出点数,并设计了输出扩展电路;根据SPI总线及HC595的时序特点,确定了SPI的时钟模式,解决了时序的配合问题,并确定了输出点数的逻辑顺序;UDTY端接一下拉电阻,保证其处于高电平,SPI2CLK信号取反后输入到HC595,保证其采样到稳定的SPI输出数据,滤波电容,提高了电路抗干扰性能;编程实现对扩展输出点数的控制。实际应用表明,该设计方案经济、可靠。     

高压动态无功补偿装置运行试验系统的研究

为验证动态无功补偿装置的性能,本文通过分析装置工作原理,提出了一种高压动态无功补偿装置运行试验系统,采用10 kV电源经有载调压器作为试验主电源;通过多组变压器变换满足多种电压等级的高压无功补偿装置的试验需求;设计陪试无功补偿装置与被试品进行互补的工作原理,在达到对试品进行试验考核的同时降低了试验对电网的冲击及实验室进线电源的需求.通过试验验证,该试验系统具有SVC及SVG运行性能的考核能力.     

Local Epidermal Endocrine Estrogen Protects Human Melanocytes against Oxidative Stress,a Novel Insight into Vitiligo Pathology

As the outermost barrier of the body, skin is a major target of oxidative stress. In the brain, estrogen has been reported synthesized locally and protects neurons from oxidative stress. Here, we explored whether estrogen is also locally synthesized in the skin to protect from oxidative stress and whether aberrant local estrogen synthesis is involved in skin disorders. Enzymes and estrogen receptor expression in skin cells were examined first by quantitative real-time PCR and Western blot analyses. Interestingly, the estrogen synthesis enzyme was mainly localized in epidermal keratinocytes and estrogen receptors were mainly expressed in melanocytes among 13 kinds of cultured human skin cells. The most abundant estrogen synthesis enzyme expressed in the epidermis was 17β-hydroxysteroid dehydrogenase 1 (HSD17β1) localized in keratinocytes, and the most dominant estrogen receptor expressed in the epidermis was G protein-coupled estrogen receptor 1 (GPER1) in melanocytes. To investigate whether keratinocyte-derived estradiol could protect melanocytes from oxidative stress, cultured human primary epidermal melanocytes (HEMn-MPs) were treated with H₂O₂ in the presence or absence of 17β estradiol or co-cultured with HSD17β1 siRNA-transfected keratinocytes. Keratinocyte-derived estradiol exhibited protective effects against H₂O₂-induced cell death. Further, reduced expression of HSD17β1 in the epidermis of skin from vitiligo patients was observed compared to the skin from healthy donors or in the normal portions of the skin in vitiligo patients. Our results suggest a possible new target for interventions that may be used in combination with current therapies for patients with vitiligo.