Retinopathy of prematurity and bilirubin--no clinical evidence for a beneficial role of bilirubin as a physiological anti-oxidant

The prevention of retinopathy of prematurity (ROP) remains a persistent problem. A previous report has focused on the possible protective effect of bilirubin on the development of ROP. These results still await clinical confirmation by other research groups. Therefore, we undertook a retrospective clinical study trying to confirm this attractive hypothesis. Twelve premature newborns under 32 weeks of gestation with ROP stage 3-4 were matched for gestational age with 12 infants without ROP. Data were collected about the infant's characteristics, medical illnesses, ventilatory settings and treatments. The total serum bilirubin concentrations between the 1st and 8th postnatal day were also gathered. The two matched groups were comparable as to their basic data, clinical characteristics and treatment, except for a slight, but significant longer duration of phototherapy for group ROP 0 (mean, 50.2 h; SD 48,6 vs 31.6 h; SD 42.7 in ROP 3-4; P = 0.02). No statistical difference relative to bilirubin was found between the two groups, neither when expressed as daily mean concentrations, nor as area under the curve (AUC) (mean, ROP 0: 17876.7; SD 6077.3 vs 18888.4; SD 55552.7 in ROP 3-4; P = 0.404) or AUC/h (mean, ROP 0: 135.1; SD 36.3 vs 144.1; SD 23.2 in ROP 3-4; P = 0.515). Our findings do not confirm the hypothesis of a clinically measurable, beneficial role of bilirubin on the development of ROP.     

Assessment of HDPE geomembrane performance in a municipal waste landfill double liner system after eight years of service

In the late 1970s and early 1980s, environmental regulations were upgraded in a general national movement to effect secure management of our municipal and residual solid wastes. The new regulations required varying combinations of natural and/or synthetic barrier and drainage layers to prevent the unrestricted release of contaminants.

The acceptable barrier materials included synthetic flexible membrane liners (FMLs) of various types. One of those most commonly used has been high-density polyethylene (HDPE) geomembrane. HDPE has been selected because of its good chemical resistance characteristics, among others. Background compatibility testing has shown the HDPE geomembrane to be extremely resistant to the leachates that are generated by municipal and residual solid waste landfills. The background testing for design has generally been based on relatively short-term tests that are conducted under extreme conditions to ‘forecast’ service life.

Recently, a municipal solid waste landfill double liner system that was constructed in 1988 was exhumed. The HDPE geomembranes of this liner system had been exposed to varying degrees of leachate since 1989. Samples of the HDPE were extracted from the in-place liner system and were laboratory-tested for physical, mechanical and endurance properties. The selected suite of tests duplicated the test protocol conducted in 1988 as part of the liner system construction quality assurance (CQA) program.

The results of this testing show that the HDPE properties are still within the range of data generated by the original testing in 1988. No degradation in properties was indicated by this testing program. The HDPE had been exposed to the leachate, methane, and static and dynamic stresses for approximately 8 years. The results of this test program support the design selection of HDPE as the synthetic barrier component of this landfill liner system.     

Effect of high alkalinity levels on geotextiles. Part 2: NaOH solution

Alkaline water has been known to affect polymeric materials, such as geotextiles, and this on-going study is aimed at providing a data base to see the extent, nature and incidence of the effects. An earlier study used calcium hydroxide to provide the alkalinity, whereas this study uses sodium hydroxide. Solutions of pH 10 and pH 12 (with pH 7 as control) were prepared and various geotextiles were incubated up to 120 days. Flow tests and strength tests were conducted on all test specimens on a weekly basis for the entire duration.

Results of the two phases (i.e. calcium and sodium) essentially parallel one another in that the alkalinity increases the flow time for a given volume of solution to pass through the geotextile. The effect is more pronounced for pH 12 than for pH 10. A precipitate is formed which rests either upon or within the fabric structure causing the major portion of the increased flow time.

In addition to this blinding and/or clogging phenomenon is a strength reduction in some of the fabrics. Certain polyester fabrics show measurable strength losses, while others do not. The type of polyester (there are over 200 types) is felt to play a major (but unknown) role in this selection process. Considerable research into both surface and internal morphologies seems to be warranted. Future efforts will be targeted in these directions.     

Photodriven,Flexural–Torsional Oscillation of Glassy Azobenzene Liquid Crystal Polymer Networks

Cantilevers composed of glassy, photoresponsive liquid crystalline polymer networks (LCNs) are shown to oscillate at high frequency (～50 Hz) and large amplitude when exposed to light from a 442 nm coherent wave (CW) laser. Added dimensionality to previously reported in‐plane oscillations is enabled by adjusting the orientation of the nematic director to the long axis of the cantilever yielding in‐plane bending accompanied by out‐of‐plane twisting (flexural–torsional oscillation). The fundamental photoresponse of this class of glassy azobenzene liquid crystal polymer networks (azo‐LCN) is further probed by examining the influence of cantilever aspect ratio, laser intensity, and temperature. The frequency of photodirected oscillations is strongly correlated to the length of the cantilever while the amplitude and threshold laser intensity for oscillation is strongly correlated to temperature.     

Thalamic NMDA transmission in a genetic model of absence epilepsy in rats

OBJECTIVES: Whether menopause per se influences fat distribution independently of the effect of aging remains controversial. The lack of consistency in the menopause related changes in body fat distribution may be the result of differences in the methods for measuring fat distribution or in the characteristics of the women studied. The aim of this cross sectional study in obese women was to compare total body composition and regional fat and lean distribution, in premenopausal, perimenopausal and postmenopausal women. METHODS: Body composition was assessed by dual energy X-ray absorptiometry (DEXA) in premenopausal (n = 26), perimenopausal (n = 24) and postmenopausal (n = 73) obese women with no intercurrent diseases. RESULTS: It was shown that postmenopausal obese (n = 73) women had a higher proportion of total fat mass in the trunk and a lower proportion of total fat and lean mass in the femoral and leg regions than premenopausal women after adjustment for age and total fat mass. In the same analysis, perimenopausal women had a lower proportion of total fat in the leg and femoral regions and of total lean in the femoral region than premenopausal women; they had a regional body composition similar to that of postmenopausal women. CONCLUSION: The present data indicate that in obese women, post menopause and perimenopause are associated with differences in fat and lean distribution, independently of age and total fat.