光学相干断层扫描仪对原发性开角型青光眼患者早期诊断价值

目的探讨光学相干断层扫描仪(OCT)在原发性开角型青光眼(POAG)患者早期诊断中的价值。方法选取2015年4月至2016年4月于张家口市第四医院就诊的50例(50眼)POAG患者为研究对象,分为早期POAG组26例和中晚期POAG组24例,另同期选取30例健康无眼疾体检者为对照组,采用OCT检测3组对象视网膜神经纤维层(RNFL)厚度、视野缺损,测定视盘面积、视杯面积、盘沿面积、视杯容积、盘沿容积等视盘参数,并对3组检测数据进行比较。结果早期POAG组和中晚期POAG组患者上方、下方、鼻侧、颞侧4个视野RNFL厚度均显著低于对照组(P<0.05),中晚期POAG组患者上方、下方、鼻侧、颞侧4个视野RNFL厚度均显著低于早期POAG组(P<0.05);早期POAG组和中晚期POAG组患者上方、下方、鼻侧、颞侧4个视野缺损值均显著高于对照组(P<0.05),中晚期POAG组患者上方、下方、鼻侧、颞侧4个视野缺损值均显著高于早期POAG组(P<0.05);POAG患者视盘面积与对照组比较差异无统计学意义(P>0.05),早期POAG组和中晚期POAG组患者盘沿面积、盘沿容积低于对照组(P<0.05),视杯面积、视杯容积高于对照组(P<0.05),中晚期POAG组患者盘沿面积、盘沿容积显著低于早期POAG组(P<0.05),视杯面积、视杯容积显著高于POAG组(P<0.05)。结论 OCT可真实反映POAG患者RNFL厚度及视盘参数的改变,具有较高的敏感性和特异性,认为RNFL厚度及视盘参数可作为早期POAG诊断的敏感指标。     

高度近视伴原发性开角型青光眼视乳头及视网膜神经纤维层改变的分析

目的分析伴有高度近视的开角型青光眼(primary open angle glaucoma,POAG)的视乳头形态及视网膜神经纤维层改变,探讨其早期诊断方法。方法(1)收集20例(38只眼)高度近视合并POAG患者资料(A组),与随机抽取的20例(36只眼)中度近视合并POAG患者的资料(B组),以及20例(40只眼)低度近视合并POAG患者的资料(C组)进行对照,比较初次就诊时3组患者间视野缺损、视网膜神经纤维层缺损(retinal nerve fibre layer de-fect,RNFLD)、最高眼压值及矫正视力等指标的差异;(2)观察3组患者的眼底照片并分析各组的临床特点。结果(1)A组患者中、重度视野缺损和RNFLD的比例明显高于B、C组,矫正视力低于B、C组;(2)高度近视患者视乳头、视网膜的特异性变化及视乳头周围的特征性改变等,干扰了对青光眼的早期诊断;(3)高度近视患者常规进行散瞳检查或眼底照相是诊断早期青光眼的重要手段及方法。结论在合并高度近视的POAG临床检查及诊断时,应注意其视野的缺损、RNFLD,并避免与高度近视视乳头、视网膜的特异性变化及视乳头周围的特征性改变相混淆,正确认识高度近视本身及合并POAG时的临床特点,有助于POAG的早期诊断。     

原发性开角型青光眼与正常眼HRT-Ⅱ视盘形态结构的对比研究

目的探讨Heidelberg视网膜断层扫描仪(HRT-Ⅱ)在原发性开角型青光眼(POAG)早期诊断中的意义。方法用HRT-Ⅱ对早期、进展期POAG30例(48眼)及正常人25例(50眼)的视盘进行断层扫描,获得视盘平均地形图像和视盘结构诸参数,将POAG视盘参数与视野平均缺损(MD)行相关性分析。结果POAG与正常人视盘结构各参数中视盘面积、视杯面积、盘沿面积、杯盘面积比、视杯容积、盘沿容积、平均视杯深度、最大视杯深度、轮廓线高度变化值、视杯形态测量、平均神经纤维层厚度存在明显差异,检测的视野平均缺损与HRT-Ⅱ视盘检测参数具有一致性。结论HRT-Ⅱ能够反映POAG视盘改变,与视野相关性好,为临床早期诊断POAG提供了依据。     

傅立叶OCT在早期原发性开角型青光眼中的诊断能力

目的：评价傅立叶域相干光断层成像术[Fourier-Domain Optical Coherence Tomography,FD-OCT, using the RTVue -100 (Optovue Inc, Fremont, California,USA）]在鉴别正常眼及早期原发性开角型青光眼（POAG）中的能力。 方法：横断面研究。对符合入选标准的早期原发性开角型青光眼组及正常组的所有受试者行FD-OCT及Humphrey视野（Humphrey Field Analyzer model 740, Carl Zeiss Meditec, Dublin, CA, USA）检查。比较早期POAG患者及正常人各视盘测量参数、神经纤维层厚度及后极部神经节细胞复合体(GCC)厚度;对早期POAG患者及正常人各测量参数绘制受试者操作特征曲线（ROC）,计算ROC曲线下面积（AROC）,敏感性、特异性及阳性和阴性似然比评估各参数的诊断性能。 结果：分析34例早期POAG患者及42例正常人结果。在特定特异度（95% and 85%）下垂直杯盘比（C/D vertical ratio）的灵敏度和阳性似然比最高,分别为79.4%和88.2%,33.4和7.4。在所有单一参数中,垂直杯盘比的AROC最大,为0.930。使用logistical诊断模型联合垂直杯盘比、RNFL AT on 3.45mm和盘沿面积,AROC为0.949。 结论：FD-OCT所测得的视盘、神经纤维层厚度及GCC厚度改变在早期POAG患者及正常人差异有显著性。以AROC、敏感性、特异性及阳性和阴性似然比为评价指标,位居前三位的指标为：垂直杯盘比、RNFL AT on 3.45mm和盘沿面积。     

Octopus 101GKP动静态自动视野计在原发性开角型青光眼诊断中的应用

目的评估Octopus101 GKP动静态自动视野计在原发性开角型青光眼（POAG）诊断中的应用价值。方法 对2006年10月-2007年3月在我院门诊确诊的30例POAG患者及34例正常人分别进行Octopus101GKP动静态自动视野计的GKP及TOP程序的检查。分析比较这两组受试者的视力、眼压、眼底C／D值及联合检查所得的平均缺陷度（MD）、丢失方差（LV）、不同视标参数下等视线的面积和检查时间等参数。结果 POAG组的平均视力、平均眼压和眼底平均C／D值与正常对照组相比差异均有显著性（P均=0．000）;两组的眼压（IOP）与平均缺陷度及等视线面积均无相关性;Ⅲ4e与Ⅰ2e两种不同的视标参数对POAG患者检出的等视线面积差异有显著性（P=0．000）;POAG组的平均检查时间为（307．78±134．50）s,明显高于正常对照组的（228．12±75．33）s（P=0．001）;正常对照组静态视野检查所得的平均缺陷度和丢失方差明显小于POAG组（P均=0．000）;静态视野检查的敏感性为80％,特异性为45％;动态视野检查的敏感性为86％,特异性为63％;两者联合检查敏感性为90％。结论 Octopus101GKP动静态自动视野计可同时完成静态及动态视野检查,通过反应时间减少个体差异,提高检查结果的准确性;同时还可通过改变视标大小、背景光明暗、视标移动速度提高POAG早期缺损检出的可能性,大大提高了POAG检出的敏感性,对于一些早期有小的周边缺损的患者更具优势。     

彩色对比视野检查法在早期诊断青光眼中的临床应用

目的探讨彩色对比视野检查法(color contrast perimetry,CCP)在青光眼早期诊断中的价值,并为其在青光眼的早期诊断方面建立一个参考标准。方法利用Oculus全自动视野计对71例正常人、33例可疑青光眼、36例早期原发性开角型青光眼(POAG)分别进行标准白色视野检查(white-on-white perimetry,W/W)与CCP检查。结果正常对照组、可疑青光眼组、早期POAG组CCP检测的全视网膜光敏感度均值(MS)低于W/W检测的结果,两者有显著意义;CCP检测光敏感度缺损均值(MD)与W/W检测的结果,正常人组无显著意义,其它两组有显著意义。CCP检查正常人组与可疑青光眼组的MS差异有显著意义,W/W检查无显著意义;两组的MD差异均有显著意义。CCP检查与W/W检查正常人组与早期POAG组的MS差异有显著意义;两组的MD差异也有显著意义。CCP与W/W检查早期POAG视野损害的符合率为100%,而CCP检查的敏感性为61.5%,两种视野检查法检测青光眼视野缺损的阳性率,CCP检查为90%,W/W检查为74%,两者差异有显著意义。正常人群的CCP视野阈值的参考值范围是20.127±2.612。结论CCP与W/W在早期POAG视野检查中具有一致性,但CCP更敏感,检出的阳性率更高,检出的视野缺损范围也更大更深。正常人群的CCP视野阈值范围的建立为青光眼早期诊断打下了基础。     

激光偏振光扫描测定不同病程开角型青光眼视网膜神经纤维层的厚度

【目的】探讨激光偏振光扫描仪对开角型青光眼诊断的临床应用价值。【方法】收集正常人159例252眼及不同病程开角型青光眼共107例175眼,采用激光偏振光扫描仪（GDxVCC）进行视网膜神经纤维层（RNFL）厚度测量,测量参数包括：RNFL厚度上方平均值、下方平均值、全周平均值、TSNIT标准差、双眼对称性及神经纤维层指数（NFI）。独立样本t检验比较正常组与青光眼组RNFL厚度及正常组与早期青光眼组RNFL厚度,单因素方差分析比较早、中、晚期青光眼RNFL厚度,对GDxVCC诊断青光眼的效能进行ROC曲线下面积分析。【结果】GDxVCC测量的正常人全周RNFL厚度为（58&#177;5）μm,青光眼患者全周RNFL厚度为（48&#177;11）μm,较正常人明显变薄（P〈0.001）。早期青光眼患者的全周、上方、下方RNFL厚度均较正常人变薄,差异有统计学意义（P=0.000）;但早期青光眼患者的双眼对称性仍较好,与正常人相比差异无统计学意义（P=0.058）。随着青光眼的进展,早、中、晚期青光眼患者的全周、上方、下方RNFL厚度明显变薄,TSNIT标准差及双眼对称性明显减低,神经纤维指数明显增高（P〈0.005）。GDxVCC各参数诊断青光眼的ROC曲线下面积达到0.743～0.992。【结论】GDxVCC可定性和定量测量RNFL厚度,其各参数诊断青光眼的效能较高,对青光眼的早期诊断有较高的临床应用价值。     

激光偏振光扫描测定不同病程开角型青光眼 视网膜神经纤维层的厚度

 【目的】 探讨激光偏振光扫描仪对开角型青光眼诊断的临床应用价值。【方法】 收集正常人159例252眼及不同病程开角型青光眼共107例175眼,采用激光偏振光扫描仪(GDxVCC)进行视网膜神经纤维层(RNFL)厚度测量,测量参数包括:RNFL厚度上方平均值。下方平均值。全周平均值。TSNIT标准差。双眼对称性及神经纤维层指数(NFI)。独立样本t检验比较正常组与青光眼组RNFL厚度及正常组与早期青光眼组RNFL厚度,单因素方差分析比较早。中。晚期青光眼RNFL厚度,对GDxVCC诊断青光眼的效能进行ROC曲线下面积分析。【结果】 GDxVCC测量的正常人全周RNFL厚度为(58 ± 5) μm,青光眼患者全周RNFL厚度为(48 ± 11) μm,较正常人明显变薄(P < 0.001)。早期青光眼患者的全周。上方。下方RNFL厚度均较正常人变薄,差异有统计学意义(P = 0.000);但早期青光眼患者的双眼对称性仍较好,与正常人相比差异无统计学意义(P = 0.058)。随着青光眼的进展,早。中。晚期青光眼患者的全周。上方。下方RNFL厚度明显变薄,TSNIT标准差及双眼对称性明显减低,神经纤维指数明显增高(P < 0.005)。GDxVCC各参数诊断青光眼的ROC曲线下面积达到0.743 ~ 0.992。【结论】 GDxVCC可定性和定量测量RNFL厚度,其各参数诊断青光眼的效能较高,对青光眼的早期诊断有较高的临床应用价值。     

Cirrus HD-OCT检测原发性开角型青光眼视乳头旁视网膜神经纤维层厚度与视野平均缺损相关性分析

目的探讨Cirrus HD-OCT测量原发性开角型青光眼(POAG)视盘旁视网膜神经纤维层(RNFL)厚度与视野缺损的相关性。方法选择2010年5月~2013年12月于中国石油天然气集团公司中心医院确诊的POAG患者62例(80眼)及视力正常人30例(40眼,正常组),POAG患者分为早期POAG组(28例,34眼)、进展期POAG组(22例,26眼)和晚期POAG组(12例,20眼),采用频域Cirrus HD-OCT和Synemed EP-930自动视野计对和POAG患者和正常组分别进行RNFL厚度和视野检测。频域Cirrus HD-OCT检测RNFL厚度采用optic disc cube 200×200模式。视野检测采用Synemed EP-930自动视野计30°-2程序。将各组患者全周平均RNFL厚度及视乳头周围4个象限(上方、下方、鼻侧、颞侧)RNFL厚度进行比较;计算平均RNFL厚度和视野平均缺损的相关性。结果正常组、早期POAG组、进展期POAG组和晚期POAG组平均RNFL厚度分别为(101.10±9.80)、(94.32±14.05)、(82.73±15.21)、(64.57±14.73)μm,而不同阶段的青光眼患者全周平均RNFL厚度及视乳头周围4个象限(上方、下方、鼻侧、颞侧)RNFL厚度均比正常人减少,差异均有高度统计学意义(P<0.01)。随着青光眼病程的发展,RNFL厚度逐渐下降,而且平均RNFL厚度和视野平均缺损(MD)之间呈负相关(r=-0.659,P=0.000)。结论平均RNFL厚度和视野MD呈线性相关。Cirrus HD-OCT测量的RNFL厚度参数,能客观、定量分析POAG对RNFL损伤进展速度,有助于对青光眼的诊断和随访,从而为POAG患者得到更早的早期诊断和用药指导提供帮助。     

原发性开角型青光眼的视网膜缺血监测检查与分析

目的对原发性开角型青光眼(POAG)病人进行视网膜缺血监测(RIM)检查及分析,探讨RIM在POAG中的临床应用价值。方法对10例20眼POAG病人及正常人10例20眼(对照组)进行RIM检查,记录振幅及潜伏期;POAG病人并行光学相干断层扫描(OCT)检查,记录视网膜神经纤维层平均厚度。结果与对照组相比,POAG中、晚期病人RIM振幅降低,潜伏期延长,差异有显著性(F=57.256、17.976,t=5.517～9.959,P<0.05);早期病人RIM振幅、潜伏期差异无显著性(P>0.05)。POAG病人中期与晚期组间比较,振幅、潜伏期差异无统计学意义(P>0.05)。RIM振幅与视网膜神经纤维层平均厚度呈正相关(r=0.735,P<0.05),潜伏期与神经纤维层平均厚度呈负相关(r=-0.629,P<0.05)。结论 RIM尚不能作为POAG病人早期诊断的指标;RIM振幅与潜伏期出现异常时,POAG已进展到中期,视网膜缺血已较为严重,应积极治疗。     

分离格栅模式视觉诱发电位对开角型青光眼早期诊断的临床观察

目的 探讨分离格栅模式视觉诱发电位( ic-VEP)定性模式检查在开角型青光眼早期诊断中的应用价值,为临床青光眼早期诊断提供客观敏感而有效依据.方法 随机选择原发性开角型青光眼患者68例(82眼)和正常对照者47例(76眼),分别进行ic-VEP与视野、视网膜神经纤维层厚度(RNFLT)进行多元相关分析,分析ic-VEP在开角型青光眼诊断中的敏感度及特异度.结果 青光眼组和正常对照组年龄、屈光度和中央角膜厚度差异均无统计学意义,而青光眼组患者的眼压、视野、RNFLT和ic-VEP与正常组相比差异具有统计学意义(P＜0.01).在青光眼组患者中,ic-VEP信号噪音比(SNR)与屈光度、眼压、视野和RNFLT的相关性分析表明,ic-VEP SNR与眼压、视野和RNFLT损伤显著相关(P＜0.01). ic-VEP检测开角型青光眼的敏感度为90. 2% ,特异度为88. 2% . ic-VEP与视野检查及 RNFLT损伤的一致性较好.结论 ic-VEP对原发性开角型青光眼的诊断具有较高的敏感度和特异度,视野、RNFLT 的损伤和 ic-VEP SNR相关.     

Retinal nerve fiber layer in primary open-angle glaucoma with high myopia determined by optical coherence tomography and scanning laser polarimetry with variable corneal compensation

Background Fundus changes associated with high myopia (HM) may mask those associated with primary open-angle glaucoma (POAG). Characteristic retinal nerve fiber layer (RNFL) thickness profiles in patients with POAG and HM were examined using optical coherence tomography (OCT) and scanning laser polarimetry with variable corneal compensation (GDxVCC), and the diagnostic capabilities of these imaging modalities were compared. Methods Twenty-two eyes with POAG and HM (spherical equivalent [SE] between -6.0 and -12.0 D) were evaluated, and 22 eyes with HM were used for comparison. RNFL parameters evaluated included superior average (Savg-GDx), inferior average (Iavg-GDx), temporal-superior-nasal- inferior-temporal (TSNIT) average, and nerve fiber indicator (NFI) on GDxVCC and superior average (Savg-OCT), inferior average (Iavg-OCT), nasal average (Navg-OCT), temporal average (Tavg-OCT), and average thickness (AvgThick-OCT) on OCT (fast RNFL scan). Visual field testing was performed and defects were evaluated using mean defect (MD) and pattern standard deviation (PSD). Results The RNFL parameters (P < 0.05) that were significantly different between groups included Savg-GDx, Iavg-GDx, TSNIT average, NFI, Savg-OCT, Iavg-OCT, Tavg-OCT, and AvgThick-OCT. Significant correlations existed between TSNIT average and AvgThick-OCT (r = 0.778), TSNIT average and MD (r = 0.749), AvgThick-OCT and MD (r = 0.647), TSNIT average and PSD (r = -0.756), and AvgThick-OCT and PSD (r = -0.784). The area under the receiver operating characteristic curve (AUROC) values of TSNIT average, Savg-GDx, Iavg-GDx, NFI, Savg-OCT, Iavg-OCT, Navg-OCT, Tavg-OCT, and AvgThick-OCT were 0.947, 0.962, 0.973, 0.994, 0.909, 0.917, 0.511, 0.906, and 0.913, respectively. The NFI AUROC was the highest value. Conclusion RNFL thickness was significantly lower in all but the nasal quadrant in patients with POAG and HM, compared to patients with only HM. Measurements with OCT and GDxVCC were well-correlated, and both modalities detected RNFL thickness changes. However, GDxVCC was better than OCT in detecting POAG in HM patients.     

Retinal nerve fiber layer in primary open-angle glaucoma with high myopia determined by optical coherence tomography and scanning laser polarimetry

Background Fundus changes associated with high myopia (HM) may mask those associated with primary open-angle glaucoma (POAG).This study aim to determine the characteristics of RNFL thickness changes in...     

Diagnostic capability of Fourier-Domain optical coherence tomography in early primary open angle glaucoma

Background Optical coherence tomography （OCT） is a high resolution noncontact imaging modality which can quantitatively detect the optic disc and retinal structure.This study was designed to evaluate the diagnostic capability of parameters of the optic disc, retinal nerve fiber layer thickness, and ganglion cell complex （GCC） using a new technology called Fourier-domain OCT （FD-OCT） for early primary open angle glaucoma （POAG） patients.Methods Two groups of patients, early perimetric damage POAG and normal subjects were included in this observational cross-sectional study.All patients underwent FD-OCT and visual field examination in addition to full ophthalmic examinations.Receiver operating characteristic curves （ROC） were studied for all parameters.The sensitivity and specificity for distinguishing between normal and early glaucomatous eyes, the areas under the receiver operating characteristic curves （AROC） and positive, negative likelihood ratios were evaluated for all the single parameters and selected combined parameters using arbitrary cutoffs.Results Thirty-four eyes of 34 early POAG patients and 42 eyes of 42 normal subjects were analyzed.Cup/disc （C/D）vertical ratio presented the best sensitivity and positive likelihood ratio for selected specificities （95% and 85%） which were 79.4% and 88.2%, 33.4 and 7.4, respectively.Among all single parameters, the C/D vertical ratio demonstrated the highest AROC which was at 0.930.The average thickness of circumpapillary RNFL on 3.45 mm showed the highest AROC among all of the peripapillary RNFL parameters.The sensitivity at selected specificity and AROC of GCC were not as high as C/D vertical ratio and RNFL AT on 3.45 mm.When the C/D vertical ratio, RNFL AT on 3.45 mm, and rim area were combined using a logistical diagnostic model, the AROC was raised to 0.949 but not significantly different from the top single parameter, C/D vertical ratio.Conclusions The key parameters obtained by FD-OCT were able to show the significant differences of optic discs,thickness of RNFL and GCC between POAG patients and normal subjects.According to sensitivity, specificity, likelihood ratio and AROC, the top three parameters from FD-OCT for early diagnosis of POAG were C/D vertical ratio, RNFL AT on 3.45 mm, and the rim area.     

Optical coherence tomography in measuring retinal nerve fiber layer thickness in normal subjects and patients with open-angle glaucoma

Objectives To investigate image characteristics and thickness of the retinal nerve fiber la yer (RNFL) in normal and glaucomatous eyes using optical coherence tomography ( OCT), and analyze the relationship between RNFL thickness and visual field index. Methods Eighty-three normal persons (150 eyes) and 83 patients with primary open angle glaucoma (POAG, 149 eyes) underwent OCT examinations with 3.4 mm diameter circ le scan to calculate the RNFL thickness. Statistical analysis was used to compa re differences in RNFL thickness in quadrants and means between the normal and g laucomatous groups and the different stages of POAG. Linear correlation and reg ression analysis were used to show the correlation between RNFL thickness and vi sual field index of 115 eyes in glaucomatous patients. Reproducibility, sensiti vity and specificity of RNFL measurements using OCT were evaluated.Results RNFL thickness measured by OCT in normal subjects was thicker in superior and in ferior, less in temporal, and thinnest in nasal quadrants. The curve showed dou ble peaks. RNFL of glaucomatous patients showed local thinning or defect, diffu se thinning, or both. The mean RNFL thicknesses of the normal group in the temp oral, superior, nasal and infeior quadrants were 90.1±10.8 μm, 140.4±10. 5 μm, 85.2±14.0 μm, and 140.4±9.7 μm, respectively with a mean of 1 14.2±6.0 μm.The numbers for the glaucomatous group were respectively 56.0 ±31.0 μm, 81.0±36.3 μm, 47.1±27.5 μm, and 73.4±38.4 μm for th e four quadrants, with a mean of 64.6±28.8 μm. There was a significant dif ference in RNFL thickness between the normal and glaucomatous groups (P&lt;0. 000), and the three stages (early, developing and late) of glaucomatous groups ( P&lt;0.000). There was a close negative relationship between RNFL thickness a nd visual field index (r=-0.796, P&lt;0.0001). The sensitivity and speci ficity of RNFL thickness in POAG measured using OCT were 93.3% and 92.0%, res pectively.Conclusions OCT can quantitatively measure RNFL thickness differences between normal persons and glaucomatous patients. RNFL thickness gradually decreases while visual fie ld defect increases with the development of POAG.     

应用光学相干断层成像术检测开角型青光眼视网膜神经纤维层厚度

目的:探讨光学相干断层成像术(OCT)检测开角型青光眼视网膜神经纤维层(RNFL)厚度与视野损害的关系,评价OCT在早期诊断青光眼中的意义。方法:正常人30例(52眼),高眼压9例(14眼)以及分成早期、进展期、晚期的原发性开角型青光眼48例(74眼)。采用Humphrey全自动视野计、Zeiss鄄HumphreyOCT分别进行视野以及视盘周围RNFL厚度检测。比较正常组、高眼压组以及青光眼组的RNFL厚度,分析青光眼组视野检测的平均缺损(MD)与RNFL厚度的关系。结果:正常组与高眼压组RNFL厚度差异无显著性(P>0.05);青光眼组较正常组、高眼压组RNFL厚度明显变薄,晚期青光眼表现为弥漫性RNFL缺损。视野检测的平均缺损与RNFL厚度呈负相关(P<0.05)。结论:OCT能够反映青光眼RNFL厚度的改变,为临床早期诊断青光眼提供更多的信息。     

原发性开角型青光眼患者视神经盘沿面积、视网膜神经纤维层厚度与分辨光敏感度之间的关系

目的 评估原发性开角型青光眼患者视神经盘沿面积(RA)、视网膜神经纤维层(RNFL)厚度与分辨光敏感度(DIS)之间的关系.方法 采用海德堡视网膜断层扫描仪、激光扫描偏振仪和标准自动视野计分别检测51例原发性开角型青光眼患者(随机选取每例患者1只眼,分为青光眼视野正常组31只和视野损害组20只)的视神经RA、RNFL厚度和DLS,对其在视盘总体及各个象限中的联系分别进行直线和对数曲线拟合性比较.结果 对于青光眼总体,视野DLS与视神经RA或RNFL厚度在视盘总体及各个象限均具有显著相关性,两者的对数曲线回归模型拟合性明显优于直线.在青光眼视野正常组,两者的相关性表现为弱或无,相互关系呈接近水平的直线(R~2=0.01～0.26).在青光眼视野损害组,两者的联系显著增强,呈对数曲线联系(R~2=0.15～0.84).视神经RA和RNFL厚度具有良好的直线相关性.结论 原发性开角型青光眼患者的视神经RA、RNFL厚度与DLS之间具有良好的相关性.