Phototherapeutic Keratectomy Combined with Photorefractive Keratecto-my for Treatment of Myopia with Corneal Scars

Phototherapeutickeratectomy(PTK)hasbeenawel1--establishedmethodforthetreatmentofkeratOPathy['--']andphotorefractivekeratectomy(PRK)hasbeenprovedeffectiveinthetreatmentofmyopia.ButnoreportswereavailableonPTKcom-binedwithPRKtotreatmyopicpatientswithcornealscars.1PATIENTSANDMETHODSFromJune,l996toMay,l998,24myopiccas-es(30eyes)withcornealscarswerelncludedinthestudy.Meanagewas32.7years(agerangingfrom17to60y).Theyincluded10men(l2eyes)andl4women(18eyes).Meancourseofdiseasewasll.3y(rangi…     

Assessment of Respiratory lmpedance During Deep Slow Breathing with lmpulse Oscillometry in Patients with Chronic Obstructive Pulmonary Disease

Breathingexerciseisanimportantapproachforrehabilitationofpatientswithchronicobstructivepul monarydisease(COPD).TraditionalChinesemedicine(TCM)hasahistoryofovertwothousandyearsandChinesetraditionalbreathingexercise(Qigong)isanimportantcomponentofTCM.LotsofinvestigationsaboutthetherapeuticeffectsofbreathingexerciseonpatientswithCOPDhavebeenreportedinChina(1,2).　　Deepslowbreathingexercise(DSBE)isoneofbreathingregulationmethodsinChinesetraditionalbreathingexercise.Toourknowledge,thereh…     

Preliminary observation on treatment of patients with Japanese B encephalitis with monoclonal antibody

The monoclonat antibodies(McAbs)against Japanese B encephalitis virus for clinicaluse were prepared according to the standards of Food and Drug Administration(FDA,USA).Immediately after the diagnosis,the patients were given 10 mg of McAbs(IgG)in normal salineby intravenous drip plus intramuscular injection.The average febrifugal days of the McAb treat-ment group(55 cases),symptomatic treatment group(12 cases),ribavirin treatment group(17cases)and thymus peptides treatment group(7 cases)were 2.86,6.20,7.16 and 9.11d,respec-tively(P<0.05 or P<0.01).It is necessary to take the skin test before use of the McAbs andto give dexamethasone during the McAb treatment.     

Neutrophil Phagocytic Dysfunction in Patients with Periodontitis

Neutrophil phagocytosis was examined in 21patients with periodontitis as experimental group(EG) including 11 cases of localized juvenileperiodontitis (LJP) and 10 cases of rapidly pro-gressive periodontitis (RP). There were 21 caseswith healthy periodontium in control group(CG).All the subjects in this study had a noncontri-butory medical history.     

Oncol2012: Association of salivary α-amylase activity with pain relieving scale in cancer patients with bone metastasis treated with radiotherapy

Background Subjective assessment tools such as visual analog scale (VAS) or pain score are commonly used to evaluate chronic cancer-induced pain intensity. However, they are limited value. We have determined the changes of VAS and salivary α-amylase (sAA ) activity in cancer patients with bone metastasis during radiotherapy in order to discuss the correlation between them. Methods 30 patients suffering from bone metastasis were enrolled in a single institution from June 2010 to March 2011. All cases with cancer-induced bone pain received radiation therapy (RT) at the same dose (30 Gy) and fractionation (3 Gy/fraction, 5 days/week) for palliative pain relief. Heart rate(HR), Systolic vs diastolic blood pressure blood pressure(DBP/SBP), VAS of the cases were assessed before (d0), after 5 fractions (d5) and 10 fractions (d10) of the irradiation. sAA activity and salivary cortisol (SC) were respectively measured using a portable analyzer and automated chemiluminescence analyzer. Results The radiotherapy markedly decreased the VAS pain scale from 82.93?9.29 to 31.43?16.73mm (P<0.001) and sAA activity from 109.40?26.38 to 36.03?19.40U/ml (P <0.001).Moreover, there is a significant correlation between the two indices (P <0.01, r=0.541). HR decreased by 6.5% after radiotherapy, but was not associated with VAS (P >0.05). In addition, SC and BP didn’t change significantly in the study (P >0.05). Conclusion Since there was a significant correlation between sAA activity and VAS pain scale, these preliminary results suggest that this biomarker may be a valuable, noninvasive and sensitive index for the objective assessment of pain intensity in patients with cancer-induced bone pain.     

Clinical analysis of 121 patients with hypertrophic cardiomyopathy

Objective:Several studies have analyzed the clinical profiles of patients diagnosed with hypertrophic cardiomyopathy(HCM). We sought to identify its characteristics in a regional cohort of Nanjing and its adjacent region. Methods:Clinical profiles of 121 referred patients were collected and analyzed retrospectively. Data including family history, clinical symptoms, electrocardiography and recent echocardiography were collected. Results: The mean age of this population was 42±17 years(range from 6 to 76) at diagnosis of HCM. Most patients were male(60%). 48 patients(39.7%) has a family history, 19 had a sudden death in a first degree relative and 96(79.3%) were recognized with cardiac symptoms. Left ventricular outflow obstruction(gradient≥30 mmHg at rest) was presented in 26(21.5%) patients. ECG abnormalities comprised of arrhythmia in 54(51.4%) and abnormal T wave in 72(68.6%) patients. FS were higher in female than male(P = 0.001). Among younger patients(age≤50 years), LVDd and LVWP were smaller in females than males(P = 0.042 & 0.023 respectively). In older patients(age＞50 years), LVDs was higher in male(P = 0.016) and EF was higher in female(P = 0.048). Conclusion:HCM patients in the region are almost diagnosed with the presentation of cardiac symptoms; those without any symptoms could be recognized by ECG and family screening. Most cardiac hypertrophy affects the interventricular septum. LVDd, LVWP, LVDs, FS and EF showed significant differences related to age and gender.     

Effect of Muscone on Neuronal Glutamate Transporter EAAC1 Expression in Rats with Acute Cerebral Ischemia

Acutecerebralischemia(ACI)isacriticalthreattothehealthofmankind.InTCM,itisper tainedtoBISyndrome(闭证).Forwhichthethera pyofFangxiangKaiqiao(芳香开窍,toinducecon sciousnesswitharomaticdrugs)wasmostlyused(1).Musk,astherepresentativedrugofFangxiangKaiqiao,waswildlyusedinstrokeandencephalitis,etc.Insomeresearch,muskwasprovedtohavetheactionofantagonizinglocalcerebralischemia(2).Asthemainactiveingredientofmusk,musconecangothroughbloodbrainbarrierintonervesystemin 5minutesandparticipateinexcit…     

Treatment of Perimenopausal Syndrome with Ear Acupressing in Ovariectomied Women

Highfolliculestimulatinghormone(FSH),luteinizinghormone(LH)andlowestrogenlevelsthatoccurredinwomeninperimenopausalstage(PMS,includingthoseafterovariectomyandnaturalmenopausal)usuallyinduceaseriesofclinicalsymp toms,suchashotflush,sweatiness,insomniaandrestlessness.Ithasbeenreportedthatpatientswith outovulationcanbetreatedbyacupuncturethroughregulatinghypothalamicpituitaryovarianaxis(HP O)(1).CouldacupuncturealsoregulatetheHPOaxisinpatientswithPMS?Thisstudywasdesignedtoexploretheeffectso…     

Clinical Observation on the Treatment of Atrial Fibrillation with Amiodarone Combined with Shenmai Injection (参麦注射液)

Objective: To observe the therapeutic efficacy and safety of amiodarone combined with Shenmai Injection (参麦注射液) on atrial fibrillation. Methods: A total of 351 patients with atrial fibrillation caused by cardiovascular diseases and idiopathic atrial fibrillation were assigned to amiodarone group (control group, 128 cases) and amiodarone combined with Shenmai Injection group (treatment group, 223 cases). The patients in the control group received intravenous injection of 150 mg amiodarone in 10 min, followed by intravenous drip infusion at 1 mg /min and 6 h later at 0.5 mg /min until 48 h or cardioversion. The patients in the treatment group received the same treatment of amiodarone, while in addition, they received an injection of Shenmai Injection of 100 mL simultaneously. Blood pressure, ventricular rate, and cardioversion were observed. Results: The total efficiency rate was 98% (control group) and 99% (treatment group) (P0.05). The mean ventricular rate decreased 23% and 31% in the control group and the treatment group, respectively (P0.05). The mean cardioversion time of the two groups was 570±211 min and 351±123 min, respectively (P0.05). Only mild side effects were observed in both groups. Conclusion: Compared with amiodarone, amiodarone combined with Shenmai Injection takes effect more quickly with low side effects on the treatment of atrial fibrillation.     

Clinical Observation on Treatment of PostcardiotomicComplications with Chinese Herbal Medicine BasedOn Syndrome Differentiation in 58Patients with Angiocardiopathy

Objective:TostudytheeffectofChineseherbalmedicine(CHM)basedonSyndromeDifferentiationonpostcardiotomiccomplicationsinpatientswithangiocardiopathy.Methods:Aimedattreatingthefrequentlyencounteredpostcardiotomiccomplications,includingfever,coughandexpectoration,belching,abdominaldistension,palpitation,shortbreath,etc.CHMtreatmentwasappliedincombinationwithroutinewesterndrugtreatment(cardiactonic,diuretics,vasculardilatorandanticoagulant).Results:Twentyoutof22patientswithprotractedfeverandirres…     

Short-term Effect of Combined Therapy with Jinlong Capsule(金龙胶囊)and Transcatheter Arterial Chemoembolization on Patients with Primary Hepatic Carcinoma and Its Influence on Serum Osteopontin Expression

<正>Objective:To observe the clinical combination effect of Jinlong Capsule(金龙胶囊,JLC) and transcatheter arterial chemoembolization(TACE) on the patients with primary hepatic carcinoma(PHC) and JLC's influence on serum osteopontin(OPN) expression and elucidate the correlation between the serum OPN level and curative effect of JLC and TACE.Methods:A total of 98 patients with PHC were observed in a randomized controlled trial(RCT).They were assigned to the Chinese medicine(CM) group(53 patients who were treated with TACE and JLC) and the intervention group(45 patients who were treated with TACE only).The serum OPN levels were measured before and after treatment by quantitative sandwich enzyme-linked immunosorbent assay(ELISA).Forty healthy people were assigned to the control group.The clinical efficacy was observed and Karnofsky score(KPS) was graded.Results:The clinical efficacy of the CM group(60.38%) was better than that of the intervention group(40.00%),and the KPS(84.35±12.19) was higher than the intervention group(69.86±11.58)(P0.05).The serum OPN levels before and after treatment in the patients with PHC were significantly elevated compared with those in the control group(P0.01).After treatment,the OPN levels in CM group(117.69±78.50) were significantly lower compared with those in intervention group(151.09±83.90,P0.05).The OPN levels of responders were remarkably lowered than the non-responders after treatment,and the level of OPN in the CM group was lower than the intervention group(P0.05).Conclusions:The short-term clinical efficacy and the quality of life of patients with PHC can be improved by combining JLC with TACE.The serum OPN levels in PHC patients can reflect the curative effect of treatment and the prognosis of the disease.     

Sialographic follow-up study of patients with Sjogren''s syndrome.

Sialographic follow-up studies of 36 cases of Sjogren's syndrome (SS) were performed with the duration of 5-72 months (mean 25 months). Three groups were divided according to the international criteria: secondary group, 14 cases (xerophthalmia, or / and xerostomia, and connective tissue diseases), primary group, 14 cases (xerostomia and xerophthalmia), and possible group, 8 cases (xerophthalmia or xerosptomia only). Sialographic findings at follow-up examination included (1) delayed evacuation, which may occur as early as 5 months later; (2) increased punctate sialectasis; (3) decreased punctate sialectasis with globular increase; (4) punctate, globular, and cavity sialectasis with radiolucent sialolith; and (5) centripetal atrophy. The cases with secondary and possible SS without xerostomia demonstrated little involvement of the parotid gland, without sialectasis. But sialodochitis was shown when radiolucent sialolith formed. The stimulated whole salivary flow rate (SWSFR) was closely related to Sialogr     

ZHANG Ting-dong (张亭栋)—— A Pioneer in Treating Leukemia with Arsenous Acid

Prof.ZHANGTing dong,male,wasborninWuqiaoCoun ty,HebeiProvinceonNov.8,1932,andin1950graduatedfromHarbinMedicalUniver sity.Andfrom1960to1963hestudiedinandthengraduatedfromWesternDoctors classforLearningTradi tionalChineseMedicine(TCM).Prof.ZHANGhasworkedintheFirstAffiliatedHospitalofHarbinMedicalUni versityasresidentdoctor,visitingdoctor(lecturer),deputychiefdoctor(associateprofessor)andchiefdoctor(professor).HemajoredinhematologicalspecialtyofintegrativeChineseandWesternMedicine(…     

Clinical Observation on Treatment of Rheumatoid Arthritis with Fengshi Xiandan in 53 Cases

We have successfully developed Fengshi Xiandan (风湿仙丹) and used it to treat 53 cases of rheumatoidarthritis (RA),with indomethacin used to treat another 53 cases of RA as the controls.The results showedthat the rate of cure and obvious effect was 54.7% and the total effective rate was 92.4% in the treatmentgroup,as compared to 26.4% and 66.0% respectively in the control group,with an obvious difference incurative effect between the two groups (P<0.01).The improvement of all the main clinical symptoms andsigns except arthralgia in the treatment group was superior to that in the control group (P<0.05 or P<0.01).The improvement of erythrocyte sedimentation rate (ESR),rheumatoid factor (RF),C-reaction protein (CRP),immunoglobulin (Ig),T-lymphocyte subgroups,micro-circulation in nail fold,and red blood cell (RBC) andhemoglobin (Hb) of anemia patients in the treatment group was superior to that in the control group (P<0.05or P<0.01).There was an obvious difference (P<0.05 or P<0.01) in superoxide dismutase (SOD) of RBC andlipid peroxide (LPO) of plasma before treatment in the two groups as compared to normal group (P<0.05 orP<0.01).The level of SOD and LPO after treatment in the treatment group obviously tended to normal ascompared to that befbre treatment (P<0.05 or P<0.01).The reduction of LPO in the treatment group wasobviously superior to that in the control group (P<0.01).The result shows that Fengshi Xiandan (风湿仙丹)with an obvious curative effect on RA can not only control the symptoms of RA but also improve itspathologic damage and prevent its development.     

The Chemopreventive Effect of Tamoxifen Combined with Celecoxib on DMBA chemically-Induced Breast Cancer

Objective: To investigate the chemopreventive effect of tamoxifen combined with a COX-2 selective inhibitor, celecoxib, on breast cancer in rats chemically induced by 7,12-dimethylben (a)anthracene (DMBA). Methods:DMBA was irrigated into the stomaches of SD female rats to build breast cancer model. A total of 120 rats were divided into four groups: control group, tamoxifen group, celecoxib group and combined group. The incidence rate, latent period, number and volume of breast cancer were detected and analyzed. Results:The tumor incidence rate of tamoxifen group (48.15%, 13/27) and celecoxib group (50.00%,14/28) were lower than that of control group (85.71%, 24/28), but higher than that of combined group (21.43%, 6/28). The tumor's latent period of tamoxifen group (97.54±1.85 d) and celecoxib group (96.79±2.89 d) were longer than that of control group (89.50±5.99 d), but shorter than that of combined group (103.67±3.39 d). The average tumor number of tamoxifen group (1.77±0.73) and celecoxib group (1.71±0.61) were less than that of control group (3.50±1.62), but more than that of combined group ( 1.17±0.42 ). The average tumor volume of tamoxifen group (1.78±0.71 cm3) and celecoxib group (2.05±1.04 cm3) were smaller than that of control group (6.42±3.96 cm3), but bigger than that of combined group (0.71±0.96 cm3) (P ＜ 0.05 respectively).Conclusion:Celecoxib and tamoxifen are effective drugs in preventing the occurrence of rat breast cancer chemically induced by DMBA. Furthermore, combination of them has better chemopreventive effect.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Clinical Study on Effect of Fuzheng Kangbai Granule on Long-Term Survival of Patients with Acute Leukemia

Atthepresenttime,chemotherapyisthechieftreatmentofacuteleukemia(AL).Butwhilechemotherapyeliminatespathogens,italsodamagetheorganismitself.Andtherefore,whenALhasgottencompleteremissionbychemotherapyandenteredintominimalresidualleukemia(MRL)state,thepatientswould,inevitably,sufferfromDeficiency,showingthecharacteristicsof"bodyimpairmentafterEvilpathogenremoved"and"bothDeficiencyofQiandYinSyndrome"(l).Theauthorsexpectedtorebuildandrestoretheimmunefunction,andtopreventtherecurrenceandprolongt…     

Recent Advances in the Treatment of Blood Disorders with Traditional Chinese Medicine

Bloodperseandbloodincirculationaswellasbleedingandclottingprocessesareallnaturallyperceivable.ItisthereforewonderthatthegrossconceptsaboutbloodintraditionalChinesemedicine(TCM)areessentiallyidenticaltothatinWesternMedicine(WM).Asaconsequencel,.Tremendouseffortshavebeenmadeinthelast50yearstounearththetreasureandtoputtheheritageinuse..SomemajorhighlightswillbeintroducedasfolwemightbeabletofindusefulcluesorideasforthetreatmentofvariousblooddisoManysuccessfulresultswereobtainedrdersfromthewrit…     

Increased brachial-ankle pulse wave velocity is associated with impaired endothelial function in patients with coronary artery disease

Background Pulse wave velocity and flow-mediated vasodilation (FMD) are widely used as noninvasive modalities for evaluating atherosclerosis. However, it is not known whether pulse wave velocity is related to FMD in patients with coronary artery disease (CAD). Therefore, the present study was designed to investigate the alteration in brachial-ankle pulse wave velocity (baPWV) and endothelial function in CAD patients.Methods Thirty-three patients with CAD and thirty control subjects were recruited for this study. baPWV was measured non-invasively using a VP 1000 automated PWV/ABI analyzer (PWV/ABI, Colin Co. Ltd., Komaki, Japan). Endothelial function as reflected by FMD in the brachial artery was assessed with a high-resolution ultrasound device. Results baPWV was increased in CAD patients compared with control subjects [(1756.1±253.1) cm/s vs (1495.3±202.3) cm/s, P&lt;0.01]. FMD was significantly reduced in CAD patients compared with control subjects [(5.2±2.1) % vs (11.1±4.4) %, P&lt;0.01]. baPWV correlated with FMD (r =－0.68, P&lt;0.001). The endothelium-independent vasodilation induced by sublingual nitroglycerin in the brachial artery was similar in the CAD group compared with the control group.Conclusions CAD is associated with increased baPWV and endothelial dysfunction. Increased baPWV parallels diminished endothelial function. Our data therefore suggest that baPWV can be used as a noninvasive surrogate index in clinical evaluation of endothelial function.     

Ventricular remodeling and intervention with losartan following rabbit chronic hibernating myocardium

Objectives To explore the changes of myocyte and the interstitial collagen in a model of chronic hibernating myocardium (CHM) in rabbits, and to determine whether these alterations affect the cardiac function, and to further observe the effects of losartan on ventricular remodeling. Methods A left anterior descending (LAD) coronary artery stenosis was created and maintained for 4 weeks to create a CHM model in rabbits. Thirty-six rabbits were assigned to the following three groups(12 rabbits per group): CHM for 4 weeks(CHM group), low-dose of losartan intervention group for 4 weeks(LTl group, 10 mg·kg-1·d-1), high-dose of losartan intervention group for 4 weeks (LT2 group, 30 mg·kg-1·d-1); and 12 sham-operated rabbits served as controls (SO group). A microscopic imaging system (Image-Pro Plus, Olympus) was used to assess the Interstitial collagen volume fraction (ICVF) in myocardial sections with picrosirius-red staining, and a polarized light microscopy to qualitatively analysis the changes in the type and the proportion of collagen fibers, to semi-quantitatively score the proportion of collagen I to collagen III(PI/III). The expression of MMP-2, 9 and TIMP-2 was assessed by immunohistochemistry and western bloting. The myocyte apoptosis rate (Rapo) was calculated with TUNEL-staining. And echocardiography was performed to measure left ventricular end-systolic and end-diastolic diameter (LVESD, LVEED), and left ventricular short-axis fraction shortening (LVFS) and ejection fraction (LVEF). Results The animal model of CHM was induced successfully in 36 out of 39-rabbits and maintained for 28 days. Compared with the sham group, ICVF) was significantly increased (P<0.01) in CHM group; compared with CHM group, ICVF was significantly decreased (P<0.01,each) in LTl group and LT2 group, and the change were more remarkable in LT2 group, compared to LTl group(P<0.05). Compared with sham group, PI/IH was significantly increased (P < 0.01) in CHM group; compared with CHM group, PI/III was significantly decreasedin the losartan intervention groups (P<0.01,each), and the change was more remarkable in LT2 group compared to LTl group (P<0.05). Compared with sham group, the expression of MMP-2 and MMP-9 were greatly increased (P<0.01) in CHM group, while TIMP-2 were greatly decreased(P< 0.01); compared with CHM group, the expression of MMP-2 and MMP-9 were significantly decreased (P<0.01,each) .while TIMP-2 were significantly increased (P<0.01,each) in the losartan intervention groups, and the change was more remarkable in LT2 group than in LT1 group (.P<0.05). Compared with sham group, myocyte Rapo was markedly increased (P<0.01) in CHM group; compared with CHM group, myocyte Rapo was significantly decreased (P<0.01,each) in the losartan intervention groups, and the change was more remarkable in LT2 group than in LT1 group (P<0.05). Compared with sham group, LVEF and LVFS were significantly reduced in CHM group (P <0.01), compared with CHM group, LVEF and LVFS were higher (P<0.01,each) in the losartan intervention groups ,and the changes were more remarkable in LT2 group than in LTl group (P<0.05). Conclusions CHM underwent interstitial collagen proliferation and myocyte apoptosis, leading to ventricular remodeling and ventricular functional impairment, Losartan intervention reduces myocyte apoptosis and interstitial collagen proliferation, and improve ventricular function.