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Objective:To investigate whether blood-brain barrier(BBB)served a key role in the edema-relief effect of bloodletting puncture at hand twelve Jing-well points(HTWP)in traumatic brain injury(TBI)and the potential molecular signaling pathways.Methods:Adult male Sprague-Dawley rats were assigned to the shamoperated(sham),TBI,and bloodletting puncture(bloodletting)groups(n=24 per group)using a randomized number table.The TBI model rats were induced by cortical contusion and then bloodletting puncture were performed at HTWP twice a day for 2 days.The neurological function and cerebral edema were evaluated by modified neurological severity score(mNSS),cerebral water content,magnetic resonance imaging and hematoxylin and eosin staining.Cerebral blood flow was measured by laser speckles.The protein levels of aquaporin 4(AQP4),matrix metalloproteinases 9(MMP9)and mitogen-activated protein kinase pathway(MAPK)signaling were detected by immunofluorescence staining and Western blot.Results:Compared with TBI group,bloodletting puncture improved neurological function at 24 and 48 h,alleviated cerebral edema at 48 h,and reduced the permeability of BBB induced by TBI(all P<0.05).The AQP4 and MMP9 which would disrupt the integrity of BBB were downregulated by bloodletting puncture(P<0.05 or P<0.01).In addition,the extracellular signal-regulated kinase(ERK)and p38 signaling pathways were inhibited by bloodletting puncture(P<0.05).Conclusions:Bloodletting puncture at HTWP might play a significant role in protecting BBB through regulating the expressions of MMP9 and AQP4 as well as corresponding regulatory upstream ERK and p38 signaling pathways.Therefore,bloodletting puncture at HTWP may be a promising therapeutic strategy for TBI-induced cerebral edema. 相似文献
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抗冻蛋白(antifreeze protein,AFP)是一类结构多样的蛋白质,具有热滞效应(thermal hysteresis,TH,降低冰点而不改变熔点)和重结晶抑制效应(recrystalization inhabition,RI).通过非共价吸附抑制机制吸附到冰核表面,限制冰晶生长和抑制冰晶重结晶,从而保护有机体免受结冰引起的伤害.由于抗冻蛋白具有阻止冰晶生长而不破坏细胞的特点,因而利用抗冻蛋白在低温中长期保存各种细胞、组织和器官,特别在器官移植中可能具有很好的应用前景. 相似文献
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Song Wu Feng Wan Yong-shun Gao Zhe Zhang Hong Zhao Zhong-qi Cui Ji-yan Xie 《中国医学科学杂志(英文版)》2014,29(4):208-213
Objective To assess clinical effectiveness of using bilateral pectoralis major or plus rectus abdominis muscle flaps in treating deep sternal wound infection (DSWI) following median sternotomy. Methods Between January 2009 and December 2013, 19 patients with DSWI after median sternotomy for cardiac surgery were admitted to our hospital, including 14 males (73.7%) and 5 females (26.3%), aged 55±13 (18-78) years. According to the Pairolero classification of infected median sternotomies, 3 (15.8%) patients were type II, and the other 16 (84.2%) were type III. Surgical procedure consisted of adequate debridement of infected sternum, costal cartilage, granulation, steel wires, suture residues and other foreign substances. Sternal reconstruction used the bilateral pectoralis major or plus rectus abdominis muscle flaps to obliterate dead space. The drainage tubes were placed and connected to a negative pressure generator for adequate drainage. Results There were no intraoperative deaths. In 15 patients (78.9%), bilateral pectoral muscle flaps were mobilized sufficiently to cover and stabilize the defect created by wound debridement. 4 patients (21.0%) needed bilateral pectoral muscle flaps plus rectus abdominis muscle flaps because their pectoralis major muscle flaps could not reach the lowest portion of the wound. 2 patients (10.5%) presented with subcutaneous infection, and 3 patients (15.8%) had hematoma. They recovered following local debridement and medication. 17 patients (89.5%) were examined at follow-up 12 months later, all healed and having stable sternum. No patients showed infection recurrence during the follow-up period over 12 months. Conclusion DSWI following median sternotomy may be effectively managed with adequate debridement of infected tissues and reconstruction with bilateral pectoralis major muscle or plus rectus abdominis muscle flap transposition. 相似文献
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病人,女,81岁.40年前在工作时双上肢不慎被火烧伤,当年在大连化工厂医院烧伤科给予取自体腹部皮肤行前臂植皮术,术后植皮区域皮肤成活修复良好.4年前无明显诱因双侧前臂植皮区域肤色逐渐变深,无意中发现皮肤明显松弛,无不适感.近3个月自觉植皮区域疼痛不适,局部无红肿等,轻微牵拉皮肤时疼痛明显.自发病起4年皮损未见扩大.患者既往体健,否认家族有类似病患者. 相似文献
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1 临床资料 患者,男,23岁,因左下肢疼痛20 d来医院就诊.询问病史:患者2 d前在上级医院诊断为坐骨神经痛.既往健康,无药物过敏史.门诊当日给予维生素B1 100 mg,维生素B12 250靏肌注,用药约5 min时患者感到头晕、胸闷、呼吸困难、寒战,面色苍白,脉搏105次·min-1,血压80/50 mmHg,考虑为药物所致过敏性休克,立即给予平卧,氧气吸入,肾上腺素1 mg肌注,地塞米松10 mg静注,5 min后患者恢复正常. 相似文献
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目的了解大学生营养状况、营养知识的知晓情况,以便为提高大学生的营养健康水平提供依据。方法采用分层整群抽样的方法抽取某医学院校3~4年级本科学生205人,对其进行问卷调查、体格检测和实验室检查。结果医学生对营养相关知识平均得分为(80.53±11.99)分,女生高于男生(t=5.61,P〈0.01);护理学专业(86.60±10.27)高于预防医学专业(79.41±11.87),高于临床医学专业(75.91±11.28),专业间差异具有统计学意义(F=18.39,P〈0.01);医学生获取营养知识的途径主要来源于课堂教学(64.5%)、书刊报纸(46.0%)和电视广播(15.5%);BMI指数女生倾向于营养不良,消瘦发生率为27.2%,男生倾向于营养过剩,超重发生率为14.3%;男生锌、铁缺乏率分别为73.5%和8.2%,女生分别为80.8%和32.5%,铁缺乏率在性别之间差异具有统计学意义(χ2=11.20,P〈0.05)结论医学生对营养相关知识掌握情况总体较好,但营养不良发生率较高,女性血清铁和总体血清锌含量偏低。 相似文献
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目的观察维持性血液透析病人服用口服营养补充剂(ONS)的临床效果。方法 60例终末期慢性肾衰和维持性血液透析(MHD)患者随机分为两组,对照组治疗期间不控制饮食,观察组治疗期间给予ONS肠内营养支持治疗,于治疗前、治疗后3个月及治疗后6个月以主观综合营养评估(SGA)、人体测量指标和生化指标观察效果。结果除中臂肌围、身体脂肪外,观察组治疗后的各项指标明显优于对照组(P<0.05或<0.01)。结论 MHD患者大部分处于营养不良状态,ONS可满足MHD患者的营养需求,改善其营养状况,对提高生存质量有积极作用。 相似文献
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MAHAPATRA GS 《Journal of the Indian Medical Association》1958,31(12):483-486
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目的 研究营养支持疗法对艾滋病(AIDS)病人营养不良的干预效果.方法 对60例AIDS病人进行营养状况评估,根据不同情况制订有针对性的、均衡的营养配餐,实施营养支持干预.观察干预前后营养状况.结果 干预前后体重、肱三头肌皮褶厚度、血清蛋白、血红蛋白均比干预前提高,总的营养不良状况明显改善(P<0.05).结论 对AIDS病人进行营养支持疗法,能改善病人的营养状况. 相似文献
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Omwega AM 《East African medical journal》2000,77(3):121-122
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目的 分析骨科加速康复外科营养管理中口服营养补充剂的应用效果。方法 选取2020年1月至2021年1月昆明医科大学第二附属医院骨科收治的患者80例为研究对象,采用随机数字表法将其分为对照组和研究组,每组各40例。对照组予以骨科常规护理,研究组予以加速康复外科营养管理,比较两组干预效果。结果 研究组术后下床活动时间、术后住院时间、总住院时间、肠鸣音恢复时间、肛门排气时间、肛门排便时间均短于对照组,差异有统计学意义(P<0.05)。术后3d,研究组血清白蛋白和血红蛋白水平高于对照组,并发症发生率低于对照组,差异均有统计学意义(P<0.05)。结论 口服营养补充剂应用于骨科加速康复外科营养管理,能够缩短患者的术后胃肠功能恢复时间及住院时间,有助于患者营养状况改善和并发症预防,能够为患者术后康复提供良好条件,临床值得应用。 相似文献
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目的 调查NRS2002 营养风险筛查工具用于部分内科患者的可行性及营养风险发生率在住院期间的改变。方法 对神经内科、消化内科、呼吸内科三个专科新入院且符合入选标准的180 例患者采用NRS2002 进行营养风险筛查,调查该工具的可行性及该部分患者在住院期间营养风险的变化。结果 入选患者中完全适用NRS2002 的患者比例为85.0%,评定率及完全适用率最低的均为神经内科;全部患者中,营养风险发生率从入院时的32.8%上升为出院时的38.3%,住院期间神经内科及消化内科的营养风险发生率升高,呼吸内科降低。结论 NRS2002应用于部分内科患者是可行的;医护人员应对患者在住院期间的营养风险进行监测,给予适当的干预,以降低住院期间营养风险发生率。 相似文献