“The 15^th Anniversary of the Foundation of the World Federation of Acumoxi Societies”Was Held in Beijing

Ｆｒｏｍ 2 2ｔｏ 2 3ｏｆＮｏｖｅｍｂｅｒｏｆ2 0 0 2 ,ｔｈｅ 1 5ｔｈａｎｎｉｖｅｒｓａｒｙｏｆｔｈｅｆｏｕｎｄａｔｉｏｎｏｆＷｏｒｌｄＦｅｄｅｒａｔｉｏｎｏｆＡｃｕｍｏｘｉＳｏｃｉｅｔｉｅｓ (ＷＦＡＳ)ｗａｓｈｅｌｄｓｏｌｅｍｎｌｙｉｎＢｅｉｊｉｎｇ.Ｍｏｒｅｔｈａｎ 2 0 0 ｐａｒｔｉｃｉｐａｎｔｓｆｒｏｍＣｈｉｎａ ,Ｄｅｎｍａｒｋ ,Ｂｒｉｔｉｓｈ ,Ａｕｓｔｒａｌｉａ ,Ｉｔａｌｙ,Ｅｇｙｐｔ,Ｒｕｓｓｉａ ,ＳｏｕｔｈＫｏｒｅａ ,Ｉｎｄｏｎｅｓｉａ ,Ｐｈｉｌｉｐｐｉｎｅ ,ｅｔｃ .ａｔ ｔｅｎｄｅｄｔｈｉ…     

The Role of the Newly-constituted INARM （International Network of Acupuncture Research Methodology）

Ｆｏｒｏｖｅｒｓｅｖｅｎｔｙｙｅａｒｓａｃｕｐｕｎｃｔｕｒｅｈａｓｃｏｍｐｅｔｅｄｗｉｔｈｍｏｄｅｒｎｍｅｄｉｃｉｎｅｉｎｔｈｅｔｒｅａｔｍｅｎｔｏｆｖａｒｉ ｏｕｓｐｈｙｓｉｏｌｏｇｉｃａｌｄｉｓｏｒｄｅｒｓ,ｗｉｄｅｌｙｄｉｓｐｌａｙｉｎｇｉｔｓｃｌｉｎｉｃａｌｔｈｅｒａｐｅｕｔｉｃｅｆｆｉｃａｃｙｔｈａｔｎｏｄｏｕｂｔｇｉｖｅｓｉｔｔｈｅｓａｍｅｄｉｇｎｉｔｙａｓｔｈｅｏｔｈｅｒｍｅｄｉｃｉｎｅ.Ｉｎｔｈｅｌａｓｔｆｏｒｔｙｙｅａｒｓｔｈｅｖｅｒｉｆｉｃａｔｉｏｎｍａｄｅｉｎｔｈｉｓｆｉｅｌ…     

The President of WFAS Meets the Director of Traditional Medicine and Basic Drug Department of WHO

Report : On October 24 ,2006 ,Prof .Deng Liangyue ,the President of World Federation of Acupuncture-Moxi-bustion Societies ( WFAS) , meets Ms . Matsoso Malebona ,the Director of Traditional Medicine and Basic DrugDepartment of WHO.At first ,Prof .Deng Liangyue gives warm welcome to official of WHOandthen gives a brief introductiontothebackground,development ,and member societies of WFAS.Prof .Deng put emphasis onthe great support fromWHO,especially the Office for West Pacific …     

The Comparison Between Two Kinds of Integrative Medicine Therapy with the Single Mifepristone in the Treatment of Uterine Fibroids

Objective:To compare the clinical efficacy of Gongliuqing Capsule(宫瘤清胶囊)combined with mifepristone,Guizhi Fuling Capsule(桂枝茯苓胶囊)combined with mifepristone,and single mifepristone in the treatment of uterine fibroids.Methods:Retrospective analysis was performed on 307 patients with uterine fibroids receiving drug treatment in our hospital.All 307 patients has been divided into three groups according to the different drug delivery scheme,GLM group of 125 patients taking Gongliuqing Capsule and mifepristone,GFM group of 113 patients taking Guizhi Fuling Capsule(桂枝茯苓胶囊)and mifepristone,SM group of 69 patients only taking mifepristone.Comparison of the cure rate and effective rate,volume of menstruation,menstrual period and uterine fibroids,level of estrogen and the incidence of adverse reaction of the patients of the 3 groups.Results:After 90days of treatment,the efficiency of GLM and GFM group were higher than that of SM group(P<0.05),and there was no significant difference between GLM and GFM group(P>0.05).The cure rate of GLM group was higher than that of the other two groups,and the difference was statistically significant(P<0.05).The menstrual volume and period length,uterine fibroids volume of GLM and GFM group was smaller than that of SM group(P<0.05),and there was no significant difference between GLM and GFM group(P<0.05).The P and E2 level of GLM and GFM group was lower than that of SM group(P<0.05),and there was no significant difference between GLM and GFM group(P>0.05).There was no significant difference in the incidence of other sex hormone level and adverse reactions(P>0.05).Conclusions:Compared with the SM to treat uterine fibroids,the integrative medicine therapy were better.Among them,Gongliuqing Capsule(宫瘤清胶囊)combined with mifepristone has the highest cure rate.     

The potential application of the traditional Chinese herb Exocarpium Citri grandis in the prevention and treatment of COVID-19

Huajuhong(Exocarpium Citri grandis,ECG)is a traditional Chinese herbal medicine and has been used for the treatment of respiratory diseases for hundreds of years.Recently,ECG has been listed in a traditional Chinese medicine formula in the Guidelines for the Diagnosis and Treatment of Coronavirus Disease 2019(sixth edition)in China.To date,the effect and mechanism of ECG against respiratory diseases have not been systematically reviewed.In this paper,the researchers summarized the effects of ECG and its pharmacologically active compound naringin in functioning as an antitussive and expectorant,improving lung function,alleviating acute lung injury,attenuating pulmonary fibrosis,and enhancing antiviral immune response,so as to provide a reference for its clinical application in the prevention and treatment of multiple respiratory diseases,including coronavirus disease 2019.     

The effects of notoginsenoside R₁ on the intestinal absorption of geniposide by the everted rat gut sac model

Ethnopharmacological relevance

Geniposide is derived from Gardenia jasminoides Ellis (Rubiaceae). Its anti-inflammatory, antithrombotic effects as well as its preventive effect against ischemic stroke have been reported. Radix notoginseng (Chinese name tienchi or sanqi) is the dried root of Panax notoginseng (Burk.) F.H. Chen, an herb noted for its promotion of blood circulation, blood stasis removal and pain alleviation, and has been widely utilized for the prevention and treatment of microcirculatory disturbances in China and other Asian countries for many years. Notoginsenoside R₁ is an effective and structurally representative bioactive constituent of R. notoginseng. In our preliminary study, notoginsenoside R₁ was able significantly to improve the bioavailability of geniposide in beagle dogs, but the underlying mechanisms remain unknown.

Materials and Methods

The present study aimed to investigate the intestinal kinetic absorptive characteristics of geniposide as well as the absorptive behavior influenced by the co-administration of notoginsenoside R₁ using an in vitro everted rat gut sac model.

Results

The results showed good linear correlation between the geniposide absorption in sac contents and the incubation time from 0 to 120 min. The concentration dependence showed a non-linear correlation between the geniposide absorption and the concentrations 0.356–1.424 mg/mL, the absorption was saturated about 1.424 mg/mL. Notoginsenoside R₁ at 0.1 and 0.2 mg/mL concentrations was able significantly to enhance the absorption of geniposide (1.424 mg/mL) by 1.7- and 1.4-fold. Moreover, verapamil, a well-known P-glycoprotein inhibitor, was able significantly to elevate the absorption of geniposide 2.4-fold. Notoginsenoside R₁ influenced geniposide's absorption in a way similar to that of a P-glycoprotein inhibitor.

Conclusions

In conclusion, notoginsenoside R₁ significantly enhances the intestinal absorption of geniposide. As for the mechanism underlying the improvement of geniposide's bioavailability, it is proposed that notoginsenoside R₁ was able to decrease the efflux transport of geniposide by P-glycoproteins.     

The signing ceremony of the Italian version of World Journal of Acupuncture-moxibustion was held in WFAS＇ headquarter

Doctor Filomena Bangrazi Petti of Italian Association of Acupuncture-moxibustion and TCM （AIAM） paid a visit to WFAS＇ headquarter on Aug. 29, 2007.[第一段]     

The Study on the Distribution of the Healthy Young＇s Resistance Based on the Positive Oleson Auricular Map

Objective： Healthy auricle is tested by modem testing technology of physical characteristics to find the auricle＇s resistivity distribution of healthy. Drawing topographic maps offers objective indicators in order to use auricular physical properties measurement in the diagnosis of the disease to identify healthy auricle resistance distribution law. Methods： In this study the auricle＇s resistivity distribution of 60 healthy young people （20-30 years old） is surveyed by ＂Meridian Energy Analysis Device 5＂.Exploring the positive resistance of the auricle of the law with statistics and analysis. Study on the differences between the resistivity distribution of left ear and right ear. Map out an objective resistivity distribution map by Photoshop. Results： The resistance of healthy male is higher than that of female and the ears of the same subject are same. The resistance of auricle normal healthy people is different and has regular pattern. The pattern is that the resistance of the cartilage is higher than that of fat and the resistance of convex position is higher than that of depression position. Specifically, the resistance of Triangular fossa and Intertragic notch is the lowest. The resistance of Cymba concha, Cavum concha and Scapha is lower than that of Ear lobe.     

The mechanism of the opening of the blood–brain barrier by borneol: A pharmacodynamics and pharmacokinetics combination study

Ethnopharmacological relevance

Borneol is widely used in traditional Chinese medicine to facilitate the distribution of central nervous system (CNS) drugs in brain due to its ability to open blood–brain barrier (BBB), however, the underlying mechanism is still unclear. In this study, the effect of borneol on different brain regions were investigated to explore the mechanism.

Materials and methods

After oral administration of borneol (0.1, 0.2 g/kg) for seven consecutive days, SD rats were injected with Rh123 (1.0 mg/kg). The concentrations of Rh123 were detected in four brain regions of cortex, hippocampus, hypothalamus and striatum by a small animal vivo imaging system and a fluorescence microplate reader respectively. The ultrastructures of BBB were examined. Moreover, the expressions of the four transporters of ATP-binding cassette (ABC) family, multidrug resistance 1a (Mdr1a), multidrug resistance 1b (Mdr1b), multidrug resistance protein 1 (Mrp1), Mrp4, Mrp5 and breast cancer resistance protein (Bcrp) in the four brain regions were analyzed. Finally, the deliveries of borneol in the plasma and the four brain regions were examined by a pharmacokinetics study.

Results

Administration of 0.2 g/kg borneol produced loose structure in the tight junction and void structure between the endothelial cell and mesangial cell. Borneol at 0.1 g/kg and 0.2 g/kg increased the delivery of Rh123 in hippocampus and hypothalamus obviously. Permeability index followed a similar trend. Protein expression assays showed that borneol decreased the expression of Mdr1 and Mrp1 in hippocampus and hypothalamus. Further RT-PCR study showed that borneol decreased the expressions of both Mdr1a and Mdr1b in hippocampus and hypothalamus. The pharmacokinetics study demonstrated that the delivery of borneol in cortex was the most and that in striatum the least, with the deliveries of borneol in hippocampus and hypothalamus in between.

Conclusions

Borneol showed tissue specific BBB-opening effect, which was associated with its regulation of the ultrastructure of brain tissues and the expressions of Mdr1a, Mdr1b and Mrp1. The present study indicated that borneol should be used in concert with drugs targeting hippocampus or hypothalamus to exert its synergistic effect to the maximum.     

A study of the motion pivot in the spine——The measurement of the angle between the vertebra body and the inferior articular facet and its application in the spinal manipulation

spinal motion pivot, spinal manipulation, the angle of facet joint, force direction, cylinder pivot motion theory The spinal joint consists of a disc and posterior facet joints. It is the biomechanical structure that enables the spine with six (6) freedoms of movements of flexion/extension, side bends and rotations. We identified that the same spinal joints initiate, eliminate and control spinal movement. These four joints are the atlanto-occipital and the atlanto-odontoid joints, C7/T 1, T12/L1 and L5/S1. The word“pivot”is commonly used to describe an important ruruing porint or matter in Chinese language.We define the above four joints as“pivots” in this article.The joints are briefed as“Occipital-vertebral pivot”(atlanto-occipital and atlanto-odontoid joint),“cervicalthoracic pivot” (C7/T1),“thoracic-lumbar pivot” (T12/L1)and“lumbar-sacrum pivot”(L5/S1). After measuring 20 human spinal columns (dry bones), observing the angle between the vertebral body and the inferior articular faeet,reviewing the spinal anatomy and biomechanics and analyzing the Chinese spinal manipulation techniques and theory, the following is our report:     

The Effects of Invigorating Qi, Removing Blood Stasis and Tonifying the Kidney on the Expression of Ⅱ Collagen Mrna Inside the Degenerated Intervertebral Discs

It has been found from the clinical observa-tion that the method of Invigorating Qi,Remov-ing Blood Stasis and Tonifying the Kidney canhave a good regulatory effect on cervical spondy-losis.But whether this method can be effectiveor not for the tissue of degenerated interverte-bral disc is still unknown.Itwill be of greatsig-nificance for the prevention and treatmentof cer-vical spondylosis if this method can improve andpostpone the course of degeneration of the de-generated intervertebral d…     

The transmission of Chinese medicine: chop suey or the real thing?

The transmission of Chinese medicine has been far less successful than it could be. The reasons are to be found in the nature of Chinese medicine itself, but more importantly in the motivation of those involved in the process of transmission and reception. It has suffered by the unintegratedness of its knowledge and the fuzziness of its concepts. In the transmission process, Chinese medicine has suffered from the influence of Western medicine, but more importantly from Western expectations of Chinese medicine as a complementary health practice.     

The Regulation Action of Electric Acupuncture Neiguan on Arrhythmia under the Epidural Anesthesia

There were 82 gynopathic operation cases in which we used electric acupuncture（50—100 Hz）inNeiguan（PC 6）on the two sides during the operation with the continuous epidural anesthesia becausein those patients there were abnormal ECGs before the operation such as sinus tachycardia,sinusbradycardia,accidental of frequent ventricuar premature beat,artrial premature beat,Ⅰdegree or Ⅱdegrees atrioventricular heartblock,double bundle-branch heart-block,low voltage in extremity     

Clinical Study on Moxibustion Improvement of Kidney-Deficiency which Illustrates the TCM Theory of ＂The Kidney Has Its Efflorescence in the Hair＂

Ｓｕｂｊｅｃｔｉｖｅ:Ｔｏｅｘｐｌｏｒｅｉｎｔｏｔｈｅｍｅｃｈａｎｉｓｍａｎｄｓｕｂｓｔａｎｔｉａｌｆｏｕｎｄａｔｉｏｎｏｆｔｈｅｔｈｅｏｒｙ“ｔｈｅｋｉｄｎｅｙｈａｓｉｔｓｅｆｆｌｏｒｅｓｃｅｎｃｅｉｎｔｈｅｈａｉｒ” .Ｍｅｔｈｏｄｓ:4 0ｏｌｄｅｒｐａｔｉｅｎｔｓｗｉｔｈｋｉｄｎｅｙｄｅｆｉｃｉｅｎｃｙｗｅｒｅｔｒｅａｔｅｄｗｉｔｈｍｏｘｉｂｕｓｔｉｏｎａｎｄｔｈｅｉｒｈａｉｒｔｒａｃｅｅｌｅ ｍｅｎｔｓｗｅｒｅｄｅｔｅｃｔｅｄ .ＭｏｘｉｂｕｓｔｉｏｎｗａｓｇｉｖｅｎｔｏＳｈｅｎｑｕｅ (ＣＶ 8)…     

The use of plants in the medical system of the Fulni-ô people (NE Brazil): a perspective on age and gender

Objectives

The loss of traditional knowledge and practices is currently a widely discussed topic in the academic literature. From this perspective, this study was constructed with the main goals of evaluating Fulni-ô Indians’ knowledge about medicinal plants and how this knowledge is influenced by age and gender. Additionally, this study seeks to identify the sites where these resources are collected.

Methods

In order to meet our intended objectives, we performed a stratified sampling of the population; 344 indigenous persons were interviewed in an open-ended format.

Results

Although a total of 245 ethnospecies were mentioned overall, more than 50% of these plants were known by no more than three indigenous persons, which could indicate that such knowledge was not widely shared. Evaluating the influence of age, we identified a strong tendency for older persons to know more about medicinal plants than those in younger age groups. However, a critical analysis of the informants’ age groups demonstrated that significant differences were present only among some of these groups. The oldest group of indigenous people (>75 years) had inferior knowledge about medicinal plants and the diversity of the ethnospecies they cited was similar to the younger age groups. In relation to gender, men cited a total of 196 different ethnospecies and 82 of these species were exclusive to their group. Also, men have their specific ethnospecies not mentioned by women. Women cited 165 species and 51 were exclusive to their group. This indicates that although women generally held less knowledge of ethnospecies than the men, they did discuss a set of ethnospecies that were not mentioned by men. However, men on average cited more ethnospecies than women and this data support the existence of differences between the sexes.

Conclusions

Despite the lack of substantial variation in the number of ethnospecies cited by men and women on the individual level, the differences between the sexes as groups were significant. Diverse collection sources were used to attend to the therapeutic needs of the Fulni-ô Indians. Among the most important collection sites, anthropogenic areas were the primary collection sites for women, followed by the Ouricuri Forest, which was the main collection site for male indigenous persons.     

Lectures on Acupuncture Part Ⅰ Fundamentals of Acupuncture and Moxibustion Lecture Two The Three Yin Meridians of the Hand

The Lung Meridian of Hand─Taiyin 1.The Meridian [Course] Starting from the stomach（themiddle portion of the body）,going downward toconnect with the large intestine,then turninghack to the lung,its pertaining organ;risingfrom there along the,trachea to the laterosuperi-or part of the the anterior wall of the chest; thenpassing along the radial side of the palmar aspectof the arm to the tip of the thumb.     

The expression change of β-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony

Aim of the study

To investigate the expression of β-arrestins in fibroblast-like synoviocytes (FLS) from collagen-induced arthritis (CIA) rats and the effect of total glucosides of paeony (TGP).

Materials and methods

TGP and glucosides of tripterygium wilfordii (GTW) were intragastriclly administrated to collagen-induced arthritis (CIA) rats after immunization. The secondary inflammatory reaction was evaluated by hind paw swelling, polyarthritis index and histopathological changes. Antibodies to type II collagen (CII) were determined by enzyme-linked immunosorbent assay (ELISA). Synoviocyte proliferations were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl (MTT) assay. The expression of β-arrestins in synoviocytes from CIA rats was measured by western blot.

Results

The administration of TGP (25, 50, 100 mg/kg) depressed hind paw swelling and decreased the arthritis scores of CIA rats. TGP improved the pathologic manifestations of CIA. Serum anti-CII antibodies level increased significantly in CIA rats, while TGP had no effect on it. Fibroblast-like synoviocytes (FLS) proliferation was inhibited by TGP (50, 100 mg/kg). On d14, d28 after immunization, β-arrestins expression greatly up-regulated in synoviocytes from CIA rats and then returned to baseline levels on d42 after immunization. TGP (50, 100 mg/kg) significantly reduced the expression of β-arrestins.

Conclusion

An inflammatory process in vivo induces an up-regulation of β-arrestins in synoviocytes from CIA rats while TGP can inhibit this change, which might be one of the important mechanisms for TGP to produce a marked therapeutic effect on RA.