代谢综合症患者牙周状况的临床研究

目的：分析代谢综合症患者牙周状况,探讨代谢综合症在牙周疾病发生、发展中的意义。方法：选择150例诊断明确的代谢综合症患者为研究组,150例健康人作为对照组。检查记录：菌斑指数（PLI）、探诊深度（PD）、临床附着丧失（CAL）、出血指数（BI）、失牙数并计算牙周位点率。测定龈沟液及血清中白细胞介素-6（IL-6）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）水平。结果：代谢综合症组患侵袭性牙周炎、慢性牙周炎高于对照组（P〈0．01）;代谢综合症组PD、CAL、重度百分比及失牙数除BI外均高于对照组（P〈0．01）。代谢综合症患者龈沟液中IL-6、TNF-α、CRP水平高于对照组（p〈0．01）,而血清中两组无差异。相关性分析表明：MS组患者血糖水平与PLI、CAL、BI、重度百分比呈正相关（P〈0．01）,腹型（腰围水平）与PD、CAL、PLI重度百分比呈正相关（P〈0．01）。HDL-C水平与PLI、CAL、BI、重度百分比及失牙数正相关。血糖及HDL-C水平与牙周病的发病率正相关。结论：MS患者牙周疾病的发病率明显高于正常人,其中血糖、HDL-C及肥胖程度是影响牙周状况的重要因素,这种变化可能是通过MS引发炎症失衡而发生的。     

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目的了解辽宁省2型糖尿病患者的牙周状况。方法2007年7—12月在辽宁省糖尿病及代谢综合征的流行病学调查人群中按要求选取2型糖尿病伴牙周炎患者、单纯牙周炎患者、健康人为研究对象,进行问卷调查,检查6颗指数牙的牙周探诊深度(PD)、临床附着丧失(CAL)、龈沟出血指数(SBI)、简化口腔卫生指数(OHI-S)、牙齿松动度(TM),并对胆固醇(TC)、三酰甘油(TG)、空腹血糖(FPG)、葡萄糖耐量试验餐后2h血糖(OGTT 2h PG)进行检测。对上述指标进行统计分析。结果2型糖尿病患者牙周炎患病率为97.7%。排除性别、年龄、居住地、文化程度等因素的影响,2型糖尿病伴牙周炎患者的PD、CAL明显高于单纯牙周炎组。结论2型糖尿病患者牙周破坏严重,口腔卫生教育及防病、治病意识急待加强,同时应严格控制血糖、血脂等全身危险因素对牙周状况的影响。     

牙周炎与慢性阻塞性肺疾病关系的流行病学研究

目的通过流行病学调查及临床检查,探讨牙周炎与慢性阻塞性肺疾病（COPD）之间的相关性。方法收集中国医科大学附属第一医院、盛京医院、第四医院和沈阳市第八人民医院2008年10月至2009年4月确诊为COPD的患者266例,其中稳定期COPD患者160例,急性加重期COPD（AE—COPD）患者106例,检查并记录所有患者6颗指数牙（61 6、6 16）的简化1：7腔卫生指数（OHI—S）、龈沟出血指数（SBI）、牙周探诊深度（PD）、临床附着丧失（CAL）,同时对所有患者进行肺功能指标的检查,并进行口腔问卷调查。结果（1）AE—COPD组的吸烟率为47．2％,明显高于稳定期COPD组（P〈0．01）;（2）AE—COPD组的SBI、PD及CAL明显高于稳定期COPD组（P〈0．01）;（3）AE—COPD组的OHI—S、SBI、PD及CAL均与FEVl％呈负相关（r分别为-0．309、-0．333、-0．395、-0．702,均P〈0．01）,其中CAL与FEVI％的相关性最强;稳定期COPD组CAL与FEVI％呈负相关（r=-0．657,P〈0．01）。结论（1）吸烟作为牙周炎和COPD的共同危险因素,在牙周炎和COPD的发生和发展中发挥重要作用;（2）AE—COPD患者的牙周炎症程度均随着肺功能的减弱而加重,提示牙周炎与COPD之间存在一定相关性。     

202例牙周炎患者患病情况的调查

目的　调查和分析202例牙周炎患者全口余留牙的患病情况及相关因素。方法　从成都地区630名人群 中按要求选取202例牙周炎患者,年龄25~60岁,男65例,女137例,进行问卷调查,并检查全口余留牙的牙周探诊 深度(PD)、临床附着丧失(CAL)、牙龈探诊出血(BOP)、牙龈退缩(GR)的情况。每个牙检查6个位点(近颊、正中颊、 远颊、近舌、正中舌、远舌)。结果　202例患者平均PD为(3·20±0·31)mm,平均CAL为(3·50±0·10) mm,平均GR 为(0·30±0·02) mm,BOP阳性位点占全部检测位点的21·16%,有59%的患者至少有1颗牙脱落。轻、中度牙周炎 129例,占63·9%,重度牙周炎73例,占36·1%。受检患者中接受过高中和中专教育者86例,占43%;初中文化程 度者55例,占27%;受过大专以上教育者40例,占19·8%;只有小学文化程度者21例,占10%。患者受教育程度与 牙周破坏的严重程度无明显的相关性。202例患者中142例从未接受过治疗,占66%;曾洁牙者60例,占30%,接 受过正规的牙周治疗者仅8例,占4%。在近2个月内,66例患者有较重的精神压力,占33%。202例中吸烟者36 例,占18%;饮茶或咖啡者135例。结论　成都地区口腔卫生教育及防病、治病意识应加强。     

妊娠中期孕妇血清IL－1与牙周病的关系

目的：研究妊娠中期孕妇血清白细胞介素－1（IL－1）与牙周炎的关系。方法：选择60例中期妊娠妇女为研究对象,其中牙周炎30例,健康对照者30例。分别检查菌斑指数（PLI）、探诊深度（PD）、临床附着丧失（CAL）和出血指数（BI）;同时抽取空腹静脉血5mL,以ELISA法测定血清IL－1水平。结果：牙周炎组和对照组之间,PLI、PD、CAL、BI和血清IL－1均有统计学差异（P％0．05）;IL－1与牙周临床指数PLI、PD、CAL、BI间相关系数为0．692、0．556、0．342、0．683。结论：血清IL－1与PLI、PD、CAL、BI之间呈正相关关系,提示妊娠中期血清IL－1水平与牙周炎存在关联。     

牙周序列治疗在成人牙周炎患者正畸过程中疗效观察

目的：通过观察牙周菌斑中组成成分的变化,评价牙周序列治疗在成人牙周炎患者正畸过程中的作用。方法：选择47例伴有轻、中度牙周炎的成人正畸治疗患者,在正畸治疗前1个月开始牙周序列治疗并持续至正畸治疗结束,记录正畸治疗前（基线对照）和治疗后1、3、6、12月以及正畸治疗结束时的各项牙周临床指标－－菌斑指数（PLI）、牙龈指数（GI）、牙龈出血指数（SBI）、牙周袋深度（PD）、临床牙周附着丧失（CAL）;同时,每次刮取患者16、21、24、36、41、44共6颗指数牙牙周袋中牙菌斑,提取细菌DNA,利用qRT－PCR技术比较患者牙菌斑中主要细菌（牙龈卟啉单胞菌Pg、具核梭杆菌Fn、福赛坦氏菌Tf、伴放线放线杆菌Aa）检出率有无差异。结果：配合牙周序列治疗,成人牙周炎患者正畸治疗过程中与治疗结束时各项牙周检查指标（PLI、GI、SBI、PD、CAL）较治疗前有明显改善（P＜0．05）,牙菌斑中Pg、Fn、Tf、Aa检出率较治疗前明显降低（P＜0．05）;与正畸治疗前比较,正畸治疗结束时患者牙菌斑中Pg检出率约降低8．5％,Fn检出率约降低21．3％,Tf检出率约降低23．4％,Aa检出率约降低36．2％。结论：成人牙周炎患者在正畸治疗前及治疗过程中同时进行牙周序列治疗可促进牙周疾病的愈合,改善患者口腔中细菌微生物的生态系统。     

牙周健康指数与胰岛素抵抗的相关性探讨

目的：评价糖尿病患者牙周健康指数对胰岛素抵抗的影响。方法：将24例伴有牙周炎的血糖控制不良的2型糖尿病（T2DM）患者随机分成两组,实验组在接受糖尿病规范化治疗的同时进行牙周非手术治疗,对照组只接受糖尿病规范化治疗,不予以牙周病治疗,测量并比较牙周治疗前、治疗后1、3、6、12月龈沟出血指数（SBI）、牙周探诊深度（PD）、牙周附着水平（AL）、空腹血糖（FPG）、空腹血浆胰岛素（FINS）,计算胰岛素抵抗指数（（HOMA—IR）,对HOMA—IR与上述指标行相关分析和多元线性逐步回归分析。结果：实验组牙周健康指数明显优于对照组（P〈0．05）,且胰岛素抵抗指数低于对照组（P〈0．05）;牙周健康指数SBI、PD、AL与胰岛素抵抗指数呈显著正相关（分别rs=O．877,r=0．925,r=0．933）,多元线性逐步回归分析显示HOMA—IR与PD、AL呈正相关。结论：控制2型糖尿病伴有牙周炎患者的牙周健康指数,有益于改善胰岛素抵抗。     

半导体激光辅助治疗伴2型糖尿病的慢性牙周炎的疗效分析

目的 评价半导体激光辅助治疗伴2型糖尿病的慢性牙周炎的临床疗效。 方法 将40例伴2型糖尿病的牙周炎患者随机分为试验组和对照组,每组20例,80颗患牙480个位点。试验组行牙周基础治疗,辅助二极管激光治疗;对照组只做牙周基础治疗。观察患者治疗前、治疗后3、6个月的牙周临床指标,包括龈沟出血指数（sulcus bleeding index ,SBI)、探诊深度（probing depth ,PD）、临床附着丧失（clinical attachment loss ,CAL）,以及全身指标（血清超敏C-反应蛋白、糖化血红蛋白、空腹血糖）。 结果 两组患者治疗后3、6个月,所有牙周指标以及全身指标均显著低于治疗前（P＜0.05）。治疗后3个月,实验组SBI、PD以及所有全身指标均显著低于对照组（P＜0.05）。治疗后6个月,实验组的SBI、PD以及糖化血红蛋白仍显著低于对照组（P＜0.05）,而CAL、超敏C-反应蛋白以及空腹血糖水平,两组无统计学差异（P＞0.05）。 结论 使用半导体激光辅助治疗伴2型糖尿病的牙周炎患者,可以更好地控制患者牙周炎症状况,同时,也更有利于患者短期内全身炎症状况以及糖代谢水平的控制。     

中重度牙周炎松牙固定的临床研究

目的：观察中重度牙周炎松动牙,通过Biosplint固位纤维牙周夹板固定前后PD、CAL、PIL、BOP等临床指标的变化,及探讨个别树脂粘合夹板失败病例的原因,总结中重度慢性牙周炎松动牙的治疗方法与特点。方法：对我科2012~2013年15例中重度牙周病患者（90颗牙）,基础治疗后采用Biosplint固位纤维材料加Dyract flow流动树脂固定。分别测量基线0月,固定后3月,6月,12月的各项牙周临床指标,并用ANOVA对其进行统计学分析。结果：固定后PD,CAL,PIL,BOP出现显著性的降低。结论：采用Biosplint固位纤维材料固定松动牙时,辅以口腔医师的专业维护及术后患者良好的个人护理,是松牙固定成功的关键因素。Biosplint固位纤维材料固定松动牙是治疗中重度周炎行之有效的措施。     

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目的评价利用Florida探针对不同程度牙周炎的基础治疗疗效。方法随机选择2005年6月至2007年6月期间,中国医科大学口腔医学院牙周科轻度、中度和重度牙周炎患者各50例为研究对象,全部行牙周基础治疗。患者在治疗前和治疗结束后3个月时采用Florida探针检测患者的探诊深度(PD)和临床附着丧失(CAL),检测位点为患者全口天然牙(不包括第三磨牙)的近中颊、颊侧正中、远中颊和舌侧正中4个位点。轻度牙周炎共检测1370颗牙5480个位点,中度牙周炎1180颗牙4720个位点,重度牙周炎940颗牙3760个位点,比较治疗前后PD、CAL的变化。结果中、重度牙周炎的PD和CAL均有明显改善(P<0.05)。轻度牙周炎PD治疗前后的改变差异无统计学意义(P>0.05),附着丧失略微加重。结论牙周基础治疗对中、重度牙周炎具有良好的治疗效果。轻度牙周炎在治疗时应注意避免器械的过度使用,以免引起医源性损伤。Florida探针能够较准确、客观地评价牙周状况。     

Severe periodontitis is associated with diastolic blood pressure elevation in individuals with heterozygous familial hypercholesterolemia: a pilot study

Background: This pilot study evaluates the association of severe periodontitis with pulse wave velocity (PWV), carotid artery intima‐medial thickness (IMT), and clinical, metabolic, and atherogenic inflammatory markers in 79 subjects with heterozygous familial hypercholesterolemia (hFH). All subjects were free of previous vascular disease manifestations. Methods: The body mass index (in kilograms per square meter), plasma lipids, glucose, C‐reactive protein, and white blood cell counts were evaluated. After full‐mouth periodontal examinations, patients were categorized into the severe periodontitis group (SPG) or non‐severe periodontitis group (NSPG). Results: The SPG showed significantly higher values of cholesterol‐year scores, triglycerides, glucose, PWV, IMT, and diastolic blood pressure (DBP) (P ≤0.05) than the NSPG. After adjustment for traditional risk factors for atherosclerosis, only the association between severe periodontitis and DBP (odds ratio: 3.1; 95% CI: 1.1 to 8.5; P = 0.03) was confirmed. Conclusion: In individuals with hFH, severe periodontitis was associated with a higher DBP, which suggests that severe periodontitis, itself, may contribute to the increased cardiovascular risk profile in this population.     

Severe periodontitis is associated with systemic inflammation and a dysmetabolic status: a case-control study

BACKGROUND AND AIM: A cluster of metabolic factors defines a syndrome that predisposes to diabetes and cardiovascular disease. Chronic infections such as periodontitis might alter these individual metabolic factors and the systemic inflammatory burden. The aim of this study was to investigate the association between severe periodontitis and increase in inflammatory and metabolic risk factors for cardiovascular disease. MATERIALS AND METHODS: We examined 302 patients with severe periodontitis and 183 healthy controls, and we collected a blood sample from each subject in order to investigate differences in inflammatory (leukocyte numbers and differential counts) and metabolic markers (lipids and glucose). RESULTS: After correcting for differences in age, gender, smoking and ethnicity, periodontitis subjects exhibited a low-grade systemic inflammation (increased white cell counts, 1.10+/-1.02 x 10(9)/l, 95%CI 1.05-1.15, p=0.0001), dyslipidemia [lower high-density lipoprotein cholesterol, 1.14+/-1.03 mmol/l, 95%CI 1.08-1.20, p<0.0001 and higher low-density lipoprotein cholesterol, 1.12+/-1.03, 95%CI 1.05-1.19, p<0.0001) and increased non-fasting serum glucose levels (1.04+/-1.01 mmol/l, 95%CI 1.02-1.06, p=0.01) when compared with controls. The associations were confirmed in a subpopulation of Caucasian non-smokers. A trend for a dose dependent effect of the number of periodontal pockets on the tested inflammatory and metabolic markers was observed. Conclusions: These data suggest a possible link between severe generalized periodontitis, systemic inflammation and a dysmetabolic state in otherwise healthy individuals.     

Left ventricular geometry and periodontitis in patients with the metabolic syndrome

Objective

The presence of periodontal disease (PD) in subjects affected by the metabolic syndrome (MetS) may affect their risk of developing cardiovascular disease. The aim of this cross-sectional study was to investigate the systemic impact of PD in MetS, by assessing measures of sub-clinical atherosclerosis and left ventricular mass and geometry.

Materials and methods

A total of 103 patients undergoing treatment for MetS were examined for confirmation of diagnosis, blood sampling, and measures of pulse wave velocity (PWV), carotid intima-media thickness (c-IMT), left ventricular mass index (LVM), and relative wall thickness (RWT). All subjects underwent a detailed dental assessment, including measurements of DMFT (decayed-missing-filled teeth) and periodontal parameters.

Results

Ten patients (10%) were diagnosed with healthy-mild periodontitis, 38 patients (37%) were diagnosed in the moderate periodontitis group, and 55 (53%) had severe periodontitis. A total of 37% of subjects were affected by dental caries. Linear regression analysis revealed that patients with severe PD had increased average ventricular RWT (adjusted p = 0.032). Average full mouth probing pocket depth (PPD) was also associated with RWT (adjusted p = 0.006). No associations between PD and c-IMT, PWV, and LVM were detected after adjusted analyses.

Conclusion

This study suggests that periodontitis may be associated with concentric left ventricular remodeling, a predictive index of cardiovascular events.

Clinical relevance

The presence of periodontitis in patients with MetS might have an effect on left ventricular geometry. These findings stress the importance of prevention, diagnosis, and management of periodontitis in patients with MetS.

Trail registration

NCT03297749

     

牙周炎与慢性阻塞性肺疾病关系的初步研究

目的:初步探讨牙周炎与慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)的关系.方法:选择符合纳入标准的受试者498 名,其中轻度、中度及重度牙周炎组分别为77 人(15.5%),143 人(28.7%),278 人(55.8%).牙周检查包括:牙周探诊深度(probing depth, PD),牙周附着丧失(attachment loss, AL),龈沟出血指数(sulcus bleeding index, SBI),菌斑指数(plaque index, PLI),牙槽骨吸收水平.通过支气管舒张剂吸入试验测定受试者肺功能水平.结果:COPD组的AL、PLI及牙槽骨吸收水平显著高于非COPD组.其中不同程度牙周炎组之间第1 秒用力呼气容积占预计值的百分比(FEV1%预计值)(F=3.59,P=0.028)及第1秒用力呼气容积占用力肺活量的百分比(FEV1/FVC)(F=4.84,P=0.008)的差异有统计学意义.支气管舒张剂后"FEV1%预计值"及"FEV1/FVC"与牙周检查指标(AL,PLI,牙槽骨吸收水平)之间均有显著负相关关系.结论:COPD与牙周检查指标(AL,PLI,牙槽骨吸收水平)之间存在相关性.     

不同牙周状态下龈沟液中瘦素水平的比较

目的:检测牙周健康者、慢性龈炎和慢性牙周炎患牙龈沟液中瘦素水平,为牙周炎的早期诊断提供客观指标。方法:选择牙周健康者、慢性龈炎和慢性牙周炎患者3组,治疗前记录牙周各项临床指标,并用Whatman^ 1号滤纸收集颊侧近远中牙周袋内GCF采用ELISA检测瘦素含量;同时收集血清进行瘦素水平的检测。结果:3组中慢性牙周炎组龈沟液中瘦素水平与牙周健康者龈沟液中瘦素水平比较有显著差异(P<0.05),慢性牙周炎组龈沟液中瘦素水平与慢性龈炎龈沟液中瘦素水平及慢性龈炎组龈沟液中瘦素水平与牙周健康者龈沟液中瘦素水平比较均无显著差异;牙周健康者、慢性龈炎和慢性牙周炎患者血液中瘦素水平比较均有显著差异(P<0.05)。血中的瘦素与临床指标PLI (P<0.01,r=0.593)、PD(P<0.05,r=0.920)、BI(P<0.05,r=0.862)、AL(P<0.05,r=0.846)均相关;龈沟液中的瘦素与临床指标PLI(P<0.01,r=0.813)、PD(P<0.05,r=0.962))、BI(P<0.05,r=0.720、AL(P<0.05,r=0.946)均相关。结论:龈沟液中瘦素水平可能是反映牙周组织状况的一项较为客观的指标。     

Group of serum inflammatory markers and periodontitis-metabolic syndrome coexistence in Koreans

Background: Recent epidemiologic studies have shown that individuals with periodontitis have a significantly increased risk of metabolic syndrome (MetS). Chronic infection and subsequent production of systemic inflammatory markers may be associated with this increased risk. The aim of present study is to determine whether the presence of periodontitis and MetS is associated with a group or an individual of C‐reactive protein (CRP), interleukin (IL)‐1β, IL‐6, IL‐8, tumor necrosis factor‐α (TNF‐α), and homocysteine (HCY) in the serum of a Korean population. Methods: Medical and periodontal parameters, including CRP, IL‐1β, IL‐6, IL‐8, TNF‐α, and HCY, were evaluated in 118 individuals (73 healthy; 20 with periodontitis only; 13 with MetS only; and 12 with both). The community periodontal index was used to assess periodontitis. Age, sex, monthly household income, smoking, and drinking were evaluated as confounders. Analysis of covariance, linear regression analysis, and factor analysis were applied. Results: The group of serologic cytokines was synergistically associated with the periodontitis–MetS coexistence. TNF‐α and IL‐6 were two representing serologic cytokines in the group. Conclusions: Our results suggest that a group of systemic biologic markers represented by TNF‐α and IL‐6 might mediate the association between MetS and periodontitis adjusted for various confounders. Additional evidence is needed to generalize our results more widely.     

上海市不同职业成人牙周健康状况抽样调查

目的抽样调查和分析400例上海市常住在职成年人牙周健康情况及相关因素。方法采用分层、整群、随机抽样方法,在郊区抽取农民200例,市区抽取职员和工人各100例,年龄25～59岁,男249例,女151例,进行问卷调查,并检查全口余留牙的牙龈指数(GI)、牙周探诊深度(PD)、临床附着丧失(CAL)、牙龈探诊出血(BOP)和松动度(mobility)情况。指数牙16、11、26、31、36和46,每个指数牙检查6个位点。采用SAS6.12软件包进行统计学分析。结果上海市成年人人群简化口腔卫生指数OHI-S=2.16±0.99,口腔卫生状况中等;人群牙龈指数GI=1.2227,牙龈炎为中度流行。上海市不同职业成年人牙周破坏程度有显著差异,其中职员的牙周破坏程度最轻;不同年龄组间也有极显著差异,高年龄组的牙周破坏重于低年龄组。轻、中度牙周炎146例,占36.5%,重度牙周炎140例,占35%。受检者中,接受过高中教育者317例,占79.25%;受过大学教育者79例,占19.75%;研究生文化程度者4例,占1%。患者受教育程度与牙周破坏的严重程度无显著相关性。400例被调查者中,330例从未接受过治疗,占82.5%;曾洁牙者70例,占12.5%;接受过正规的牙周治疗者仅13例,占3.25%。结论上海地区人群口腔卫生教育及牙周防病、治病意识还须加强。     

Polymorphisms of the mannose-binding lectin gene MBL in periodontitis in patients with Down syndrome

Periodontitis is considered to be a multifactorial and lifestylerelated dental disease. In Down syndrome, the onset of periodontitis starts from an early age, and appears to be a proper phenomenon of this syndrome. One possibility is that this phenomenon relates to the immune system of individuals with Down syndrome, yet little is known about the etiology, particularly the genetic factors. Mannose-binding lectin (MBL) is an important host factor of the innate immune system and may play a role in the defense against invading microorganisms in periodontitis. Here, we investigate the distribution of single nucleotide polymorphisms (SNPs) in the MBL gene at codons 52, 54, and 57 in both subjects with or without Down syndrome, with or without periodontitis. The subjects of this study from a Japanese population were: group (i) 10 individuals without Down syndrome without periodontitis; group (ii) 18 individuals without Down syndrome with periodontitis; group (iii) 12 individuals with Down syndrome without periodontitis; and group (iv) 20 individuals with Down syndrome with periodontitis. We carried out polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) using DNA from lingual mucosal cells of subjects, and determined the genotypes of all subjects. We found no different distributions of SNPs in the MBL gene at codons 52, 54, and 57 in subjects with or without Down syndrome, with or without periodontitis. These findings suggest that frequent abnormalities of the immune system in Down syndrome are dependent on the genetic background of the individual.     

慢性牙周炎患者基础治疗前后龈沟液中瘦素水平变化的研究

目的：检测慢性牙周炎患者牙周基础治疗前后龈沟液中瘦素水平的变化。方法：选择轻、中、重度牙周炎患者共3组,每组11人,基础治疗前后收集龈沟液,采用酶联免疫法（Enzyme-Linked ImmunoSorbent Assay,ELISA）检测瘦素含量。结果：3组患者牙周基础治疗后龈沟液中瘦素水平均明显高于治疗前（P＜0.01）;瘦素与轻度牙周炎组治疗前的出血指数正相关（r=0.675）（P＜0.05）,与重度牙周炎组治疗前的探诊深度负相关（r=-0.799）（P＜0.01）;重度牙周炎组治疗后比治疗前的探诊深度减小（P＜0.01）,附着丧失减小（P＜0.05）。结论：龈沟液中瘦素含量变化与牙周炎的基础治疗密切相关,可以通过测定瘦素水平评估牙周炎治疗的临床疗效。