The m6A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis

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sEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p

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miR-22 gene therapy treats HCC by promoting anti-tumor immunity and enhancing metabolism

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Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development

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A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver

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Alcohol reshapes a liver premetastatic niche for cancer by extra- and intrahepatic crosstalk-mediated immune evasion

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ROCK inhibition enhanced hepatocyte liver engraftment by retaining membrane CD59 and attenuating complement activation

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IL-15 blockade and rapamycin rescue multifactorial loss of factor VIII from AAV-transduced hepatocytes in hemophilia A mice

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Precise editing of FGFR3-TACC3 fusion genes with CRISPR-Cas13a in glioblastoma

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Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer

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An optimized IgG-based B7-H3xCD3 bispecific antibody for treatment of gastrointestinal cancers

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The functional GRHL3-filaggrin axis maintains a tumor differentiation potential and influences drug sensitivity

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HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity

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3D genome alterations and editing in pathology

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MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease

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LAG-3xPD-L1 bispecific antibody potentiates antitumor responses of T cells through dendritic cell activation

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METTL3-mediated m6A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy

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A bispecific antibody targeting GPC3 and CD47 induced enhanced antitumor efficacy against dual antigen-expressing HCC

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Reprogramming of the heavy-chain CDR3 regions of a human antibody repertoire

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Targeting Lin28 axis enhances glypican-3-CAR T cell efficacy against hepatic tumor initiating cell population

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