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Reprogramming of the heavy-chain CDR3 regions of a human antibody repertoire
Affiliation:1. Department of Microbiology and Immunology, The Scripps Research Institute, Jupiter, FL 33458, USA;2. Genomics Core, The Scripps Research Institute, Jupiter, FL 33458, USA;3. X-ray Crystallography Core, The Scripps Research Institute, Jupiter, FL 33458, USA;4. The Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA;5. Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, China;6. School of Biology and Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China
Abstract:
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  • Keywords:Cas12a  HDR  B cell receptor  HCDR3  HIV-1 V2-glycan antibody  Mb2Cas12a  PG9  PG16  SOSIP
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