复旦大学单粒子微束研制进展

建设了一基于复旦大学2×3 MV串列加速器的单粒子微束装置。离子束经分析磁铁30°水平偏转传输后再经90°偏转磁铁竖直上行至辐照终端,以内径1.5 μm的毛细玻璃管微准直器获取离子微束。采用薄膜闪烁体结合光电倍增管的探测结构对微束离子进行精确探测和计数,并以高压静电偏转开关快速关断束流以实现对离子数目的精确控制。目前实验已获得在质子能量为3 MeV时,能散（能量分布曲线中半高宽FWHM）<60 keV、束分辨<2.2 μm、定量照射精度>95%的质子微束。本文对复旦大学单粒子微束的束流管道设计、微束获取、束开关及单粒子探测等核心环节的研制进展进行介绍。     

The Experiment of Obtaining Micron Beam in the Single-Particle Microbeam Facility of the Institute of Plasma Physics

The Experiments, methods and results of obtaining micron beam in the Microbeam Facility of the Institute of Plasma Physics were discussed in this paper. The H2^ beam was accelerated by the Van de Graa/f electrostatic accelerator, and the collimator at the end of the beam line is a 60μm thick stainless steel chip. And as a result, particle tracks on the solid track probes (CR39 film) etched in the solution of NaOH showed that the beam can go through the collimator with a small aperure (2000, 300, 55, 30, or 10μm) and 3.5μm thick vacuum film(Mylar). Besides the CR39 method, the beam was measured by an energy spectrum detector after the 10μm diameter aperture and the 3.5 μm thick vacuum film too.     

The PTB single ion microbeam for irradiation of living cells

At the PTB's ion accelerators, a new microbeam facility is now in operation that is capable of delivering single ions, for example, to the nuclei of individual living cells. The wide range of proton and ⁴He²⁺ ion energies affords LET-values between 3 and 200 keV/μm. A beam diameter of less than 2 μm outside the vacuum system has been measured and a targeting accuracy of better than 2 μm has been determined. In contrast to other microbeam facilities operated for radiobiological research using mechanical collimators in front of the target to define the beam, the PTB facility utilises beam focusing by quadrupole magnets. The microbeam has a unique ion optical design that incorporates a 90° bending magnet in the beam transport system. This design has the advantage of providing a microbeam basically without scattered particles. Every ion reaching the target is detected by a thin scintillating foil and a photomultiplier tube with efficiency close to 100%. Presently up to 1500 single cells per hour can be automatically irradiated with a chosen number of particles. Procedures and results of first cell irradiations are described as an example.     

单粒子微束品质优化装置研制的设想

对影响单粒子微束装置束品质的因素进行了全面分析，并提出了一种优化单粒子微束装置束品质的方法——用束流发射度精确测量与粒子束聚焦自动调节装置改进单粒子微束装置瞄准器出口束斑。     

单细胞单粒子微束的发展及放射生物学应用现状

综述了单细胞单粒子微束的发展及其在放射生物学方面的应用现状。通过准直或聚焦方式,可以将加速器粒子束流在空气中的束斑限定到微米或亚微米大小,而聚焦微束因其更高的空间分辨率和更快的电磁扫描照射速度成为发展主流;借助于先进的荧光显微镜及微速成像技术,当前的粒子微束能够对活细胞辐射诱导DNA损伤的早期响应进行在线可视化观测。微...     

Consideration about the Single-neutron Microbeam Facility

A conception of the single-neutron microbeam facility was put forward in this paper. The specific particle (e.g. H^ , ^2d^ or α ) bombarding a specific target can generate neutron, when the particle energy is more than a threshold (e.g., H^ energy is more than 2 MeV). And if the specific beam spot on the target is very small, the neutron beam along the direction of the specific beam spot will be very small too. If the neutron beam is weak and a neutron detector is mounted after the specific neutron collimator, the single- neutron will be obtained. Therefore, if the specific target and the neutron detector are installed after the proton accelerator and the microbeam system, the single-neutron microbeam will probably be obtained.     

Energy-spread measurement of triple-pulse electron beams based on the magnetic dispersion principle

The method of energy dispersion in magnetic field is used to analyze the energy spread of the triple-pulse electron beam generated by the Dragon-II linear induction accelerator.A sector magnet is applied for energy analysis of the electron beam,with a bending radius of 300 mm and a deflection angle of 90°.For each pulse,the time-resolved and integral images of the electron position at the output port of beam-bending line are recorded by a streak camera and a CCD camera,respectively.Experimental results demonstrate an energy spread of less than ±2.0%for the electron pulses.The cavity voltage waveforms obtained by different detectors are also analyzed for comparison.     

Panofsky magnet for the beam extraction from the synchrotron using a fast Q-magnet and RF-knockout

The fast control of the beam spill extracted from a synchrotron is a key function for the spot scanning irradiation in cancer therapy application. The authors propose an extraction method which uses the quadruple field of fast response, as well as the RF-knockout. A Panofsky magnet was developed as a quadruple magnet, with a frequency response of around 10 kHz. The Panofsky magnet has a rectangular beam aperture and plate coils attached to the pole face. A model magnet has been manufactured with ferrite, and static and dynamic magnetic fields were measured. From the measurement we observed that the effects of eddy current in the plate coils were large and the uniformity of the magnetic field gradient in the beam aperture was worse than ±5% with a plate thickness of 0.02 cm and a frequency of current of 10 kHz. For the future, in a detailed design the eddy current effects have to be taken into account.     

Applications to cultural heritage diagnostics at the new nuclear microprobe beam line at CEDAD

A nuclear microprobe beam line has been installed at CEDAD (Centre for Dating and Diagnostics), University of Salento, Lecce, Italy. The beam line is connected to the ?30° port of the high energy switching magnet of a 3 MV HVEE 4130HC Tandetron accelerator. It is based on an Oxford Microbeam magnetic quadrupole triplet and its general features are presented. The results of functional tests are presented showing how a lateral spatial resolution as low as ～2 μm has been achieved in vacuum by analysing standard reference material. The results obtained in the analysis of ancient radiocarbon dated biological tissues are presented for the identification and distribution of toxic elements such as Pb.     

电子回旋共振离子源永磁体的优化设计

对永磁电子回旋共振(Electron cyclotron resonance,ECR)离子源磁场运用Poisson程序进行了模拟计算,将模拟计算结果和测量结果进行了比较.依据计算结果,设计加工了NdFeB(钕铁硼)永磁体,得到了比较好的磁场场形,并在ECR离子源调试中获得了较强的束流.     

Beam stability improvement of the HIMAC synchrotron using a feed-forward system for magnet power supplies

In order to realize a precise dose distribution in heavy-ion cancer therapy, high beam stability is required for the accelerator complex. Owing to load fluctuation caused by the upper ring, which is one of the two rings in HIMAC, current dips of ≈5-10 Hz were observed in the power supply for the bending/quadrupole magnet of the other lower ring. The parameters of the beam stability, such as the spill variation, the beam position, and the size, were adversely affected by the current dips. In order to suppress these current dips, we developed a new feed-forward system in the magnet power supply. We verified the performance of the feed-forward system by measuring the suppression of the current dips. We also performed beam experiments to measure the variation of the horizontal tune and the structure of the beam spill, which is slowly extracted by the resonance method. The experimental result showed that the current dips were successfully reduced by the system to ΔI/I ∼ 10⁻⁶. It was also confirmed that the horizontal tune and the spill structure could be stabilized by the current dip suppression.     

用于钠泵的螺管型超导磁体设计与实验

本文对钠金属电磁泵的螺管型超导磁体部分进行了详细设计和实验研究.磁体设计指标为水平室温孔长度600mm,直径160mm,中心场磁感应强度5T.对超导磁体所用的超导线进行了短样测试,当温度为4.2K、磁感应强度为5T时,临界电流为464A,大于工作电流.磁体经过绕制、真空压力浸渍工艺后进行10次失超锻炼,在失超电流97 A的电流下测试,磁体中心磁感应强度达到4.66T.若进一步降低励磁速率,磁体中心磁感应强度预计可以达到5T左右,可以满足钠金属电磁泵的要求.     

Design study of a rotating gantry for the HIMAC new treatment facility

A project to construct a new treatment facility as an extension of the existing HIMAC facility has been initiated for the further development of carbon-ion therapy. In the new facility, one of the treatment rooms will be equipped with an iso-centric gantry system employing a 3D pencil beam scanning irradiation method. In order to realize a compact design, the final 90° bending magnet is divided into two bending magnets of 60° and 30°. The scanning magnets are set between these two bending magnets, although the aperture of the 30° magnet increases. Finally, we achieved 350 tons of total weight for 400 MeV/u carbon beams with a 150 mm square field.     

用于加速器驱动洁净核能系统的微波离子源(英文)

介绍了正在研制的用于加速器驱动洁净核能系统的微波离子源,通过离子源7.3 mm的引出孔可以引出100mA的氢离子束,质子比好于85％,离子源成功地通过了100小时可靠性试验。     

Design and Development of a Power Supply System for NBI Test Stand of EAST

A neutral beam injector (NBI) test stand was constructed to develop a multi-megawatt prototype ion source as an auxiliary heating system on experimental advanced superconducting tokamak. A power supply system for the NBI test stand components such as a set of dc power supplies for plasma generator, a dc high voltage power supply of a tetrode accelerator, a transmission line and a surge energy suppressor. Stable arc discharges of the plasma generator with hydrogen gases for 100 s long pulse have been produced by six Langmuir probes feedback loop regulation mode to control the arc power supply. The 4 MW hydrogen ion beam of 1 s is extracted with beam energy of 80 keV and the beam current of 52 A. The dc high voltage power supply for the plasma grid of the prototype ion source was designed to contribute maximum voltage of 100 kV and current of 100 A. The high voltage power output is continuously adjustable to satisfy with plasma physics experiment in operation frequency of 10 Hz. To prevent damage of the beam source at high voltage breakdown, core snubber using deltamax soft magnetic materials have been adopted to satisfy the input energy into the accelerator from the power supply can be reduced to about 5 J in the case of breakdown at 80 kV. For the transmission line, a disc shape multi cable coaxial configuration was adopted and which the dimension of the diameter is 140 mm at the core snubber. The major issues of discharge characteristics with long pulse and beam extraction with high power for the prototype ion source were investigated on the NBI test stand.     

CYCIAE-30医用回旋加速器束流输运系统升级改造

在中国原子能科学研究院CYCIAE－30医用回旋加速器现有的束流输运系统的基础上，根据气体靶生产新品种医用同位素的技术要求，用TRACE－3D对束流输运系统的升级改造方案进行设计，包括束流线的总体布局和光学设计。根据束流光学设计的结果，〖JP3〗设计了新增束流线的磁四极透镜和偏转磁铁。     

Incoherent-scatter computed tomography with monochromaticsynchrotron x ray: feasibility of multi-CT imaging system forsimultaneous measurement-of fluorescent and incoherent scatter x rays

We describe a new system of incoherent scatter computed tomography (ISCT) using monochromatic synchrotron X rays, and we discuss its potential to be used in in vivo imaging for medical use. The system operates on the basis of computed tomography (CT) of the first generation. The reconstruction method for ISCT uses the least squares method with singular value decomposition. The research was carried out at the BLNE-5A bending magnet beam line of the Tristan Accumulation Ring in KEK, Japan. An acrylic cylindrical phantom of 20-mm diameter containing a cross-shaped channel was imaged. The channel was filled with a diluted iodine solution with a concentration of 200 μgI/ml. Spectra obtained with the system's high purity germanium (HPGe) detector separated the incoherent X-ray line from the other notable peaks, i.e., the iK_α and K_β1 X-ray fluorescent lines and the coherent scattering peak. CT images were reconstructed from projections generated by integrating the counts In the energy window centering around the incoherent scattering peak and whose width was approximately 2 keV. The reconstruction routine employed an X-ray attenuation correction algorithm. The resulting image showed more homogeneity than one without the attenuation correction     

上海光源储存环新注入方式

上海光源储存环的新工作模式和新装插入件会导致动力学孔径和注入效率的减小,传统的注入方式不再满足恒流注入要求。分别从改变注入方式和减小注入束流发射度两个角度解决注入对动力学孔径的需求。脉冲多极铁与凸轨相结合的注入方式可以将动力学孔径的要求降低到7 mm以下。利用斜四极铁在高能输运线上进行水平和垂直发射度互换可以将注入束流发射度降低到近1/10而降低注入点的束斑尺寸。两者都可以将注入效率提高到95%以上。二者在更小动力学孔径的情况下同时使用还可以减小脉冲多极铁的强度。     

The nuclear microprobe at the University of Arizona

A nuclear microprobe has been operational at the University of Arizona since early 1994. It utilizes a magnetic quadrupole doublet (model QL-300 from Microscope Associates, Inc.) with an 11 mm diameter aperture and lens lengths of 6 cm each. The magnetic pole tips are electrically insulated to enable electric rotational alignment and beam rastering by application of varying voltages to the pole tips. Ion beams are obtained from a 5.5 MV model CN, High Voltage Engineering Corp. Van de Graaff accelerator with a Penning type ion source. Present mininum beam spot size is about 2 μm obtained with a 4 MeV H₂⁺ beam with a current of about 40 pA. To date, the instrument has been successfully used to map concentrations of Hg, Cr, and As in rabbit renal slices using PIXE.     

Design of neutral beam injection system for KSTAR tokamak

The neutral beam injection (NBI-1) system has been designed for providing a 300 s deuterium beam of 120 kV/65 A as an auxiliary heating and current drive system of the KSTAR (Korea Superconducting Tokamak Advanced Research) tokamak. The deuterium beam is produced from a long pulse ion source composed of a bucket-type plasma generator and a multi-aperture tetrode accelerator with the help of discharge power supplies and high voltage (HV) power supplies. The beamline components (BLCs) include a neutralizer with an optical multi-channel analyzer (OMA) section, a bending magnet (BM), an ion dump assembly, a movable calorimeter, beam scrapers, and a cryo-sorption pump system in a rectangular vacuum tank. A beam duct equipped with bellows and a voltage break is placed between the NBI vacuum tank and the KSTAR vacuum vessel. All data and parameters of the NBI system are controlled by a control and data acquisition (CODAQ) system through the EPICS based Ethernet interface.