Automatic coil selection for channel reduction in SENSE-based parallel imaging

OBJECTIVE: Coil arrays with large number of receive elements allow improved imaging performance and higher signal-to-noise-ratio. The MR systems supporting these arrays have to handle an increased amount of data and higher reconstruction burden. To overcome these problems, data reduction techniques need to be applied, realized either by linear combination of the original coil data prior to reconstruction or by discarding particular data from unimportant coil elements. MATERIALS AND METHODS: This work focuses on the latter approach and presents an efficient algorithm for automatic coil selection applicable to SENSE imaging. A singular value decomposition (SVD)-based coil selection is proposed that performs a coil element ranking quantifying the contribution of each coil element to the image reconstruction allowing appropriate coil selection. This approach makes use of the coil sensitivity information and takes reduction factor and phase encoding direction into account. RESULTS: Simulations, phantom and in vivo experiments were performed to validate the SVD-based coil selection algorithm. The proposed approach proved to be computationally efficient without remarkable image quality degradation. CONCLUSION: The SVD-based approach offers the opportunity for fast automatic coil selection. This could simplify clinical workflow and may, furthermore, pave the way for various 2D real-time and interventional applications.     

Accelerated multi-contrast high isotropic resolution 3D intracranial vessel wall MRI using a tailored k-space undersampling and partially parallel reconstruction strategy

Objective

To develop a 3D multi-contrast IVW protocol with 0.5-mm isotropic resolution and a scan time of 5 min per sequence.

Materials and methods

Pre-contrast T1w VISTA, DANTE prepared PDw VISTA, SNAP, and post-contrast T1w VISTA were accelerated using cartesian undersampling with target ordering method (CUSTOM) and self-supporting tailored k-space estimation for parallel imaging reconstruction (STEP). CUSTOM + STEP IVW was compared to full-sample IVW, SENSE-accelerated IVW, and CUSTOM + zero-filled Fourier reconstruction in normal volunteers and subjects with intracranial atherosclerotic disease (ICAD). Image quality, vessel delineation, CSF suppression, and blood suppression were compared.

Results

CUSTOM + STEP vessel wall delineation was comparable to full-sample IVW and better than SENSE IVW for vessel wall delineation on T1w VISTA and luminal contrast on SNAP. Average image quality and wall depiction were significantly improved using STEP reconstruction compared with zero-filled Fourier reconstruction, with no significant difference in CSF or blood suppression.

Conclusions

CUSTOM + STEP allowed multi-contrast 3D 0.5-mm isotropic IVW within 30 min. Although some quantitative and qualitative scores for CUSTOM − STEP were lower than fully sampled IVW, CUSTOM + STEP provided comparable vessel wall delineation as full-sample IVW and was superior to SENSE. CUSTOM + STEP IVW was well tolerated by patients and showed good delineation of ICAD plaque.

     

Recent advances in image reconstruction, coil sensitivity calibration, and coil array design for SMASH and generalized parallel MRI.

Parallel magnetic resonance imaging (MRI) techniques use spatial information from arrays of radiofrequency (RF) detector coils to accelerate imaging. A number of parallel MRI techniques have been described in recent years, and numerous clinical applications are currently being explored. The advent of practical parallel imaging presents various challenges for image reconstruction and RF system design. Recent advances in tailored SiMultaneous Acquisition of Spatial Harmonics (SMASH) image reconstructions are summarized. These advances enable robust SMASH imaging in arbitrary image planes with a wide range of coil array geometries. A generalized formalism is described which may be used to understand the relations between SMASH and SENSE, to derive typical implementations of each as special cases, and to form hybrid techniques combining some of the advantages of both. Accurate knowledge of coil sensitivities is crucial for parallel MRI, and errors in calibration represent one of the most common and the most pernicious sources of error in parallel image reconstructions. As one example, motion of the patient and/or the coil array between the sensitivity reference scan and the accelerated acquisition can lead to calibration errors and reconstruction artifacts. Self-calibrating parallel MRI approaches that address this problem by eliminating the need for external sensitivity references are reviewed. The ultimate achievable signal-to-noise ratio (SNR) for parallel MRI studies is closely tied to the geometry and sensitivity patterns of the coil arrays used for spatial encoding. Several parallel imaging array designs that depart from the traditional model of overlapped adjacent loop elements are described.     

Dynamic magnetic resonance imaging with radial scanning: a post-acquisition keyhole approach

A method—PA-keyhole—for 2D/3D dynamic magnetic resonance imaging with radial scanning is proposed. PA-keyhole exploits the inherent strong oversampling in the center of k-space, which contains crucial temporal information regarding contrast evolution. The method is based on: (1) a rearrangement of the temporal order of 2D/3D isotropic distributions of trajectories during the scan into subdistributions according to the desired time resolution, (2) a new post-acquisition keyhole approach based on the replacement of the central disk/sphere in k-space using data solely from a subdistribution, and (3) reconstruction of 2D/3D dynamic (time-resolved) images using 2D/3D-gridding with Pipe's approach to the sampling density compensation and 2D/3D-IFFT. The scan time is not increased with respect to a conventional 2D/3D radial scan of the same spatial resolution; in addition, one benefits from the dynamic information. The abilities of PA-keyhole and the sliding window techniques to restore simulated dynamic contrast changes are compared. Results are shown both for 2D and 3D dynamic imaging using experimental data. An application to in-vivo ventilation of rat lungs using hyperpolarized helium is demonstrated. Electronic Publication     

Recent advances in image reconstruction, coil sensitivity calibration, and coil array design for SMASH and generalized parallel MRI

Parallel magnetic resonance imaging (MRI) techniques use spatial information from arrays of radiofrequency (RF) detector coils to accelerate imaging. A number of parallel MRI techniques have been described in recent years, and numerous clinical applications are currently being explored. The advent of practical parallel imaging presents various challenges for image reconstruction and RF system design. Recent advances in tailored SiMultaneous Acquisition of Spatial Harmonics (SMASH) image reconstructions are summarized. These advances enable robust SMASH imaging in arbitrary image planes with a wide range of coil array geometries. A generalized formalism is described which may be used to understand the relations between SMASH and SENSE, to derive typical implementations of each as special cases, and to form hybrid techniques combining some of the advantages of both. Accurate knowledge of coil sensitivities is crucial for parallel MRI, and errors in calibration represent one of the most common and the most pernicious sources of error in parallel image reconstructions. As one example, motion of the patient and or the coil array between the sensitivity reference scan and the accelerated acquisition can lead to calibration errors and reconstruction artifacts. Self-calibrating parallel MRI approaches that address this problem by eliminating the need for external sensitivity references are reviewed. The ultimate achievable signal-to-noise ratio (SNR) for parallel MRI studies is closely tied to the geometry and sensitivity patterns of the coil arrays used for spatial encoding. Several parallel imaging array designs that depart from the traditional model of overlapped adjacent loop elements are described. Summary of material presented at the 2001 ISMRM workshop on MRI hardware, Cleveland, OH, USA.     

Basic considerations on the impact of the coil array on the performance of Transmit SENSE

Transmit SENSE adapts the idea of parallel imaging to RF transmission. Using multiple independent transmit coils, the duration of a spatially selective RF pulse can be reduced. It is known from parallel imaging that a suboptimal coil-array geometry might lead to an ill-conditioned sensitivity matrix and, thus, to a non-homogenous noise amplification in the resulting image. The current paper investigates the consequences of suboptimal coil arrays for Transmit SENSE. Two possible consequences of a suboptimal coil array are studied in the framework of numerical simulations: the incorrect excitation of the desired spatial pattern and the increase of the specific energy absorption rate (SAR), i.e. the RF power required to excite the desired pattern. Incorrect pattern excitation occurs only in pathologic coil-array scenarios. The increase of the SAR is very moderate for a large range of coil-array geometries. Using spiral excitation k-space trajectories leads to superior results compared to Cartesian trajectories. The problem of an ill-conditioned matrix inversion does not seem to play a major role in Transmit SENSE. Consequently, the freedom in designing coil arrays seems to be much larger in Transmit SENSE than in SENSE in the receive mode.     

Dual-contrast single breath-hold 3D abdominal MR imaging

Object: Multiple contrasts are often helpful for a comprehensive diagnosis. In 3D abdominal MRI, breath-hold techniques are preferred for single contrast acquisitions to avoid respiratory artifacts. In this paper, highly accelerated parallel MRI is used to acquire large 3D abdominal volumes with two different contrasts within a single breath-hold. Material and methods: In vivo studies have been performed on six healthy volunteers, combining T ₁- and T ₂-weighted, gradient- or spin-echo based scans, as well as water/fat resolved imaging in a single breath-hold. These 3D scans were acquired with an acceleration factor of six, using a prototype 32-element receive array. Results: The presented approach was tested successfully on all volunteers. The whole liver area was covered by a FOV of 350 × 250 × 200 mm³ for all scans with reasonable spatial resolution. Arbitrary scan protocols generating different contrasts have been shown to be combinable in this single breath-hold approach. Good spatial correspondence with negligible spatial offset was achieved for all different scan combinations acquired in overall breath-hold times between 15 and 25 s. Conclusion: Enabled by highly parallel imaging technology, this study demonstrates the technical feasibility and the promising image quality of single breath-hold dual contrast MRI.     

Phase compensation in single echo acquisition imaging

Parallel imaging in magnetic resonance imaging is currently the primary route to decreasing scan time. Single echo acquisition (SEA) imaging is a completely parallel imaging method that collects a full image in a single echo. This article discusses the implications related to imaging with voxel-sized coils, specifically as they relate to the potential for SEA imaging with large planar and cylindrical arrays. Phased array coils with large numbers of elements have been used to form images in SEA imaging. As implemented, the array elements are on the order of the voxel dimensions in one direction. A complication that arises in this case is the potential for signal loss due to the phase variation over the voxel impressed by the receive coil. This problem has been investigated for the cases of planar and cylindrical arrays. In the case of planar arrays, a single phase compensation pulse can be shown to easily eliminate the dephasing of the radio frequency (RF) coil. Unfortunately, for cylindrical arrays, the rotation of the coil phase gradient requires different phase compensation gradient strengths to optimize the signal from each coil, an obvious problem in single echo imaging. One potential solution is to use the cylindrical coil in the transmit/receive mode, which eliminates the need for phase compensation entirely but will require a more complex interface to the scanner.     

The intravascular contrast agent Clariscan™ (NC 100150 injection) for 3D MR coronary angiography in patients with coronary artery disease

4. Conclusion In our experience Clariscan^TM improves image quality, thus, increasing the visual length and improving the actual visible dimensions of the coronary arteries. Distal segments improved to a higher extent than the proximal parts. In that way sensitivity and specificity for the detection of significant coronary artery disease could be improved. Better SNR and CNR can be used to improve spatial resolution or to reduce scan time by techniques like SENSE or SMASH [14,15].     

High-resolution 3D whole-heart coronary MRA: a study on the combination of data acquisition in multiple breath-holds and 1D residual respiratory motion compensation

Object

To study a scan protocol for coronary magnetic resonance angiography based on multiple breath-holds featuring 1D motion compensation and to compare the resulting image quality to a navigator-gated free-breathing acquisition. Image reconstruction was performed using L1 regularized iterative SENSE.

Materials and methods

The effects of respiratory motion on the Cartesian sampling scheme were minimized by performing data acquisition in multiple breath-holds. During the scan, repetitive readouts through a k-space center were used to detect and correct the respiratory displacement of the heart by exploiting the self-navigation principle in image reconstruction. In vivo experiments were performed in nine healthy volunteers and the resulting image quality was compared to a navigator-gated reference in terms of vessel length and sharpness.

Results

Acquisition in breath-hold is an effective method to reduce the scan time by more than 30 % compared to the navigator-gated reference. Although an equivalent mean image quality with respect to the reference was achieved with the proposed method, the 1D motion compensation did not work equally well in all cases.

Conclusion

In general, the image quality scaled with the robustness of the motion compensation. Nevertheless, the featured setup provides a positive basis for future extension with more advanced motion compensation methods.     

Accelerated time-resolved 3D contrast-enhanced MR angiography at 3T: clinical experience in 31 patients

Purpose: To evaluate whether time-resolved 3D MR-angiography at 3T with a net acceleration factor of eight is applicable in clinical routine and to evaluate whether good image quality and a low artifact level can be achieved with a temporal update rate that allows for additional information on pathologies. Materials and methods: Thirty-one consecutive patients underwent time-resolved 3D contrast-enhanced MR-angiography on a 3T system. Imaging consisted of accelerated 3D gradient echo sequences combining parallel imaging with an acceleration factor of four, partial Fourier acquisition along phase and slice encoding direction, and twofold temporal acceleration using view sharing. Data volumes representing the arterial and venous contrast phases were independently evaluated by two experienced radiologists by grading of image quality and artifact level on a 0–3 scale. Results: Time-resolved MR-angiography was successfully performed in all subjects without the need for contrast agent bolus timing. Excellent arterial (average score = 2.65 ± 0.32) and good venous (average score = 2.56 ± 0.28) diagnostic image quality and little image degrading due to artifacts (average score = 2.20 ± 0.16) were confirmed by both independent readers (agreement in 65.2% of all evaluations). In 14 patients vascular pathologies were identified in the arterial phases. In eight examinations temporal resolution and depiction of contrast agent dynamics provided additional information about pathology. Discussion: Without the necessity for additional bolus timing, time-resolved 3D contrast-enhanced MR-angiography with imaging acceleration along both the spatial encoding direction and temporal domain revealed excellent diagnostic image quality in neurovascular and thoracic imaging. Despite the limited spatial resolution as compared to high-resolution imaging of the carotid artery bifurcation, the results demonstrate the applicability of contrast-enhanced MR-angiography in thoracic and abdominal MRA as well as cervical imaging with a temporal update rate allowing for additional information on pathologies. Future studies may include an evaluation of optimal trade-offs between spatial and temporal resolution, different acceleration factors and a comparison to the gold-standard for accuracy.     

Clinical evaluation of ultra-high-field MRI for three-dimensional visualisation of tumour size in uveal melanoma patients,with direct relevance to treatment planning

Objectives

To assess the tumour dimensions in uveal melanoma patients using 7-T ocular MRI and compare these values with conventional ultrasound imaging to provide improved information for treatment options.

Materials and methods

Ten uveal melanoma patients were examined on a 7-T MRI system using a custom-built eye coil and dedicated 3D scan sequences to minimise eye-motion-induced image artefacts. The maximum tumour prominence was estimated from the three-dimensional images and compared with the standard clinical evaluation from 2D ultrasound images.

Results

The MRI protocols resulted in high-resolution motion-free images of the eye in which the tumour and surrounding tissues could clearly be discriminated. For eight of the ten patients the MR images showed a slightly different value of tumour prominence (average 1.0 mm difference) compared to the ultrasound measurements, which can be attributed to the oblique cuts through the tumour made by the ultrasound. For two of these patients the more accurate results from the MR images changed the treatment plan, with the smaller tumour dimensions making them eligible for eye-preserving therapy.

Conclusion

High-field ocular MRI can yield a more accurate measurement of the tumour dimensions than conventional ultrasound, which can result in significant changes in the prescribed treatment.

     

Practical considerations for in vivo MRI with higher dimensional spatial encoding

Object

This work seeks to examine practical aspects of in vivo imaging when spatial encoding is performed with three or more encoding channels for a 2D image.

Materials and methods

The recently developed 4-Dimensional Radial In/Out (4D-RIO) trajectory is compared in simulations to an alternative higher-order encoding scheme referred to as O-space imaging. Direct comparison of local k-space representations leads to the proposal of a modification to the O-space imaging trajectory based on a scheme of prephasing to improve the reconstructed image quality. Data were collected using a 4D-RIO acquisition in vivo in the human brain and several image reconstructions were compared, exploiting the property that the dense encoding matrix, after a 1D or 2D Fourier transform, can be approximated by a sparse matrix by discarding entries below a chosen magnitude.

Results

The proposed prephasing scheme for the O-space trajectory shows a marked improvement in quality in the simulated image reconstruction. In experiments, 4D-RIO data acquired in vivo in the human brain can be reconstructed to a reasonable quality using only 5?% of the encoding matrix??massively reducing computer memory requirements for a practical reconstruction.

Conclusion

Trajectory design and reconstruction techniques such as these may prove especially useful when extending generalized higher-order encoding methods to 3D images.     

3D diffusion tensor imaging with 2D navigated turbo spin echo

A Cartesian two-dimensional navigator with variable orientation for online motion correction is introduced. It corrects for all possible zeroth- and first-order phase errors due to rigid-body motion of a subject during the diffusion-weighting preparation. The technique is developed for the application of three-dimensional (3D) imaging sequences, which offer the opportunity of high-resolution diffusion-weighted imaging, or diffusion tensor imaging (DTI) with isotropic voxel resolution. The navigator was applied to a displaced 3D turbo spin-echo sequence with an ECG-gated diffusion preparation to avoid phase errors due to gross brain pulsation. Online and offline corrected in vivo images acquired with this sequence are compared to investigate the advantages of online correction. Also eigenvector maps of the diffusion tensor are presented with an isotropic resolution of 1 mm³, which indicate that this new navigator technique is a promising approach for high-resolution DTI.     

基于三维人脸成像系统的复数域人脸识别方法

三维人脸识别是模式识别和人工智能领域的研究热点。提出了一种利用人脸图像的二维灰度信息和三维深度信息进行人脸识别的算法。首先利用相关型图像传感器构成三维实时人脸成像系统,并将获得的三维人脸物理数据用复数形式表达。再将特征脸（Eigenface）方法和Fisherface方法拓展到复数域,提出了复数域特征脸方法和复数域Fisherface方法。改进的复数域人脸识别方法在三维实时成像系统的人脸数据库中进行的人脸识别实验表明,复数域的三维人脸识别方法明显优于传统的人脸识别方法。     

Characterization of the impact to PET quantification and image quality of an anterior array surface coil for PET/MR imaging

Object

The aim of this study was to determine the impact to PET quantification, image quality and possible diagnostic impact of an anterior surface array used in a combined PET/MR imaging system.

Materials and methods

An extended oval phantom and 15 whole-body FDG PET/CT subjects were re-imaged for one bed position following placement of an anterior array coil at a clinically realistic position. The CT scan, used for PET attenuation correction, did not include the coil. Comparison, including liver SUV_mean, was performed between the coil present and absent images using two methods of PET reconstruction. Due to the time delay between PET scans, a model was used to account for average physiologic time change of SUV.

Results

On phantom data, neglecting the coil caused a mean bias of ?8.2 % for non-TOF/PSF reconstruction, and ?7.3 % with TOF/PSF. On clinical data, the liver SUV neglecting the coil presence fell by ?6.1 % (±6.5 %) for non-TOF/PSF reconstruction; respectively ?5.2 % (±5.3 %) with TOF/PSF. All FDG-avid features seen with TOF/PSF were also seen with non-TOF/PSF reconstruction.

Conclusion

Neglecting coil attenuation for this anterior array coil results in a small but significant reduction in liver SUV_mean but was not found to change the clinical interpretation of the PET images.     

A degeneracy study in the circulant and bordered-circulant approach to birdcage and planar coils

A method for finding closed-form solutions for the normal mode frequencies of systems with circulant symmetry was investigated. This method is particularly useful for questions of degeneracy that arise when one considers parallel imaging techniques like SENSE and SMASH in MRI. It is applicable to systems that include birdcage coils as well as planar coils with the appropriate rotational symmetry. A proof is given that complete degeneracy of all normal mode frequencies is impossible when all mutual inductive couplings are included. We tested the method against measurements made on a planar coil array and on an 8-element birdcage coil. The inclusion of the co-rotating end-ring mode changes the fundamental symmetry of the system from circulant to 'bordered circulant.' Closed-form solutions for the normal mode frequencies of a bordered circulant system are also given.     

A degeneracy study in the circulant and bordered-circulant approach to birdcage and planar coils

A method for finding closed-form solutions for the normal mode frequencies of systems with circulant 2pi/2 symmetry was investigated. This method is particularly good for questions of degeneracy that arise when one considers parallel imaging techniques like SENSE and SMASH in MRI. It is applicable to systems that include birdcage coils as well as planar coils with the appropriate rotational symmetry. A proof is given that complete degeneracy of all normal mode frequencies is impossible when all mutual inductive couplings are included. We tested the method against measurements made on a planar coil array and on an 8-element birdcage coil. The inclusion of the co-rotating end-ring mode changes the fundamental symmetry of the system from circulant to "bordered circulant". Closed-form solutions for the normal mode frequencies of a bordered circulant system are also given.     

有源屏蔽的超导核磁共振成象磁体的设计

本文提出了一种具有有源屏蔽的核磁共振成象(MRI)超导磁体的设计方法。主线圈和屏蔽线圈几何参数的配合应使磁场中的所有12次以下谐波完全消除,以满足MRI装置对磁场均匀度的要求。屏蔽线圈和主线圈的磁矩正好相互抵消,使离磁体较远处的杂散磁场基本消除,以满足对杂散磁场进行屏蔽的要求。屏蔽线圈径向和轴向尺寸的确定综合考虑了屏蔽效果、超导线用量、屏蔽线圈和主线圈间电磁作用力以及低温容器结构尺寸的影响。文章给出了一个设计实例。     

Accurate assessment of carotid artery stenosis in atherosclerotic mice using accelerated high-resolution 3D magnetic resonance angiography

Object  

High-resolution magnetic resonance angiography (MRA) enables non-invasive detection and longitudinal monitoring of atherosclerosis in mouse models of human disease. However, MRA is hampered by long acquisition times putting high demands on the physiological stability of the animal. Therefore, we evaluated the feasibility of accelerated MRA using the parallel imaging technique SENSE with regard to both lesion detection and quantification.