超声组织多普勒成像评价儿童先天性心脏病并肺动脉高压患者心室功能研究

目的 探讨超声组织多普勒成像技术评价儿童先天性心脏病并肺动脉高压患者心室功能的价值.方法 20例先天性心脏病并肺动脉高压、20例先天性心脏病无肺动脉高压患儿及24例门诊体检健康儿童,分别行组织多普勒超声心动图检查.心尖四腔心切面测量左心室侧壁二尖瓣环附着处、右心室侧壁三尖瓣环附着处收缩期S波峰速度(Sm)、舒张早期负向E波峰速度(Em)、舒张晚期负向A波峰速度(Am)、等容收缩间期(ICT)、等容舒张间期(IRT)、射血时间(ET),计算左心室、右心室Tei指数,比较各组间差异,并分析先天性心脏病并肺动脉高压组患儿右心室组织多普勒参数与肺动脉收缩压(sPAP)的相关性.结果 先天性心脏病并肺动脉高压组患儿左心室、右心室Em及左心室ET降低,而左心室、右心室Am、ICT、IRT、Tei指数均异常升高.右心室IRT与sPAP具有良好的正相关.结论 儿童先天性心脏病并肺动脉高压患者左右心室功能均受损,以右心室舒张功能及左心室舒张收缩功能下降为主,右心室IRT可作为预测肺动脉高压的新无创指标.     

多普勒组织成像技术评价肥厚型心肌病患者心室运动的协调性

目的应用多普勒组织成像技术（doppler tissue imaging,DTI）评价肥厚型心肌病（hypertrophic cardiomy-opathy,HCM）患者心室运动的协调性。方法对38例HCM患者和38例对照组进行常规超声心动图检查,分别测量左室内径、左室壁厚度、左室射血分数（LVEF）、二尖瓣舒张早期血流速度峰值（E）、二尖瓣舒张晚期血流速度峰值（A）、二尖瓣峰值速度比值（E/A）、等容舒张期（IVRT）、心室间机械运动延迟（IVMD）,转换DTI速度模式,分别测量二尖瓣环室间隔、侧壁、下壁及三尖瓣环右室侧壁的心肌收缩期峰值速度（Sm）、舒张早期峰值速度（Em）、舒张晚期峰值速度（Am）、Em/Am、Q-Sm（Q波起始到Sm起始的时间间期）,计算心室内收缩延迟时间（intra-V-Del）和心室间收缩延迟时间（inter-V-Del）。结果HCM组的IVSTI、VST/PWTI、VRTI、VMD、LVDd、A、E、E/A与对照组比较差异均有统计学意义（P〈0.05,P〈0.01）。HCM组室间隔、侧壁、下壁、右室侧壁节段Sm、Q-smi、ntra-V-Del、inter-V-Del、Em、Em/Am与对照组比较差异均有统计学意义（P〈0.05,P〈0.01）。结论HCM患者存在心室收缩功能下降和心室收缩运动协调障碍,DTI对HCM患者治疗效果和预测预后具有重要的临床指导意义。     

组织多普勒显像技术评价初发心肌梗死患者左室功能

目的探讨组织多普勒显像（DTI）技术在评价初发心肌梗死患者左室功能中的应用价值。方法常规超声心动图检查显示左室收缩及舒张功能正常的初发心肌梗死患者18例及与其年龄匹配的健康对照者15例入选本研究。应用DTI技术二尖瓣环平均运动速度指标评价两组对象的左室功能。同时计算二尖瓣血流舒张早期峰值速度与二尖瓣环舒张早期峰值速度的比值（E／Em）,以评估左室平均充盈压。结果心肌梗死患者组二尖瓣环收缩期峰值速度（Sm）、舒张早期速度（Em）及晚期峰值速度（Am）均明显低于正常对照组（P〈0．05）;心肌梗死组E／Em比值明显高于正常对照组（P〈0．05）。结论DTI技术可以较常规超声心动图更加敏感地检测出初发心肌梗死患者的左室功能异常。     

组织多普勒显像评价二尖瓣置换术后左心室功能

目的 探讨应用组织多普勒显像(TDI)评价二尖瓣置换(MVR)术后左室功能的临床价值.方法 45例接受MVR术后3个月以上患者为病例组,根据心律分为心房颤动组和窦性心律组,并选取30例正常人为对照组.应用常规超声心动图测量左房室腔大小、机械瓣口流速、射血分数等指标;应用TDI测量心尖四腔观二尖瓣环间隔处和侧壁处运动收缩期峰值速度(Sm)、舒张期峰值速度(Em)、等容舒张时间(IVRT);计算E/Em.结果 ①与对照组相比,MVR组二尖瓣环Sm、Em均明显减低,IVRT延长(P＜0.001),但窦性心律组与心房颤动组之间差异无统计学意义(P＞0.05);②MVR组E/Em较对照组明显增高,二者差异有统计学意义(P＜0.001),且E/Em与IVRT呈正相关;以E/Em＞15.0为最佳截断值,评价左室舒张功能变化的敏感性为91.11%,特异性为90.32%,ROC曲线下面积为0.9548±0.0402.结论 TDI能够准确评价MVR后左室功能,E/Em作为一种评价心肌舒张和左室充盈压的量化指标可以评价MVR术后患者左室舒张功能.     

Echocardiographically estimated left ventricular end-diastolic and right ventricular systolic pressure in normotensive healthy individuals

Aim To study the effect of aging on and the relationship between echocardiographically estimated left ventricular (LV) filling pressure and estimated right ventricular (RV) systolic pressure among healthy normotensive individuals.Methods We analyzed 249 healthy individuals (aged 18–82 years, 52% men) with normal echocardiographic findings and reliably measurable tricuspid regurgitation gradients. Subjects with blood pressure >140/90 mmHg and/or LV hypertrophy were excluded. LV & RV dimensions and LV mass were measured with M-mode echocardiography. Atrial (A) volumes were determined with the area-length method. Diastolic function was assessed with transmitral Doppler and mitral annulus tissue Doppler. The ratio of transmitral early peak velocity to early diastolic mitral annulus velocity (E/E′) was used as estimation of LV filling pressure. The transtricuspid Doppler gradient was used to estimate RV end-systolic pressure.Results Even in normotensive individuals aging was accompanied by an increase in LV mass and LA dimensions and an increase in relaxation abnormalities. E/E′ increased with every decade: from 7.8 for age 18–35 years to 10.9 for age ≥75 years (p<0.0001) as did the transtricuspid gradient: from 18.3 mmHg for age 18–35 years to 25.8 mmHg for age ≥75 years (p<0.0001). Linear regression showed that estimated RV systolic pressure was independently predicted by age, LA volume, LV systolic function and E/E′.Conclusion Among normotensive healthy individuals both E/E′ and tricuspid regurgitation gradients increase significantly with aging. Moreover the E/E′ ratio was independently predicting the tricuspid regurgitation gradient. These findings support the need for further studies defining age specific normal values.     

超声心动图评价高血压患者右室重构与右室功能的研究

目的 探讨超声心动图评价高血压右室重构及右室功能的临床价值.方法 高血压患者62例,按左室重量指数分为无左室肥厚组(A组,33例)和左室肥厚组(B组,29例).对照组为28例健康者.二维超声测量右室前壁厚度(RVAWTd)、右室舒张期内径(RVEDd);三尖瓣反流法估测肺动脉收缩压(PASP);脉冲组织多普勒成像技术(PW-TDI)测量三尖瓣环心肌运动收缩期峰值速度(Sm)、舒张早期峰值速度(Em)、舒张晚期峰值速度(Am)和S峰速度时间积分(Sm-VTI),分别采用PW-TDI与脉冲多普勒测量右室Tei指数.结果 与对照组比较,A、B组Em和Em/Am下降,Am和Tei指数升高(均P＜0.01);与A组比较, B组Em、Em/Am、Sm下降,Am、Tei指数、RVAWTd及PASP升高(P＜0.05,P＜0.0 1).两种方法所测Tei指数存在相关性:对照组(r＝0.78,P＜0.01),高血压组(r＝0.72,P＜0.01).结论 高血压患者右室功能减低,在左室肥厚同时可发生右室重构并进一步影响右室功能,TDI测定右室Tei指数能简便有效评价高血压右室功能.     

应用多普勒组织成像评价肥厚型心肌病左心室局部心功能

目的　应用多普勒组织成像技术评价肥厚型心肌病患者室间隔及左室后壁局部心功能。 方法　对健康志愿者(50例)与肥厚型心肌病患者(76例)在室间隔及左室后壁中段测量室壁收缩期峰值 速度、舒张早期峰值速度、舒张晚期峰值速度,比较两组舒张、收缩速度差异有无显著性意义。结果　肥厚 型心肌病组左室长轴室间隔及后壁收缩期峰值速度及舒张早期与晚期峰值速度比值均较正常组减低 (P<0.05),左室短轴仅舒张早期与晚期峰值速度比值较正常组减低(P<0.05),而收缩期峰值速度与正 常组差异无显著性意义(P>0.05)。结论　肥厚型心肌病患者肥厚室间隔及无肥厚左室后壁螺旋肌收缩 功能及舒张功能均减低,括约肌舒张功能减低。     

The Effect of Slow Coronary Flow on Right and Left Ventricular Performance

Objective

To evaluate left and right ventricular functions using tissue Doppler echocardiography (TDE) and myocardial performance index (MPI) methods in patients with slow coronary flow (SCF) and to determine the relationship between these parameters and thrombolysis in myocardial infarction frame count in SCF patients.

Subjects and Methods

Thirty-five patients (20 males and 15 females) with SCF who underwent coronary angiography and 35 age- and sex-matched controls (14 males and 21 females) without SCF who underwent elective coronary angiography were enrolled in the study. Left ventricular (LV) and right ventricular (RV) functions were examined using conventional echocardiography and TDE.

Results

LV systolic myocardial velocity (Sm), early myocardial velocity (Em), late myocardial velocity (Am), and Em/Am ratio were similar in both the SCF and control groups; however, isovolumetric relaxation time (IRT) was higher in the SCF group compared to the control group (IRT: 99 ± 17 vs. 88 ± 20; p = 0.01). In patients with SCF, LV MPI was higher than in the control group, but this was not statistically significant (0.61 ± 0.11 vs. 0.56 ± 0.12; p = 0.07). The RV tricuspid annular velocities and MPI were similar in the SCF and control groups.

Conclusion

This study showed that SCF affected LV functions echocardiographically and could cause partially reduced LV performance. In addition, SCF did not affect RV functions echocardiographically.Key Words: Right ventricular function, Left ventricular function, Myocardial performance index, Slow coronary flow, Tissue Doppler echocardiography, Coronary artery disease     

缬沙坦改善向心性重构型原发性高血压左室整体舒张功能的价值

目的观察缬沙坦改善向心性重构型原发性高血压患者左心室整体舒张功能的价值。方法应用多普勒组织成像（DTI）技术测定二尖瓣环舒张早、晚期峰值运动速度（Em和Am）厦其比值（Em／Am）。比较向心性重构型原发性高血压左室整体舒张功能减退患者口服缬沙坦3个月前后Em、Am以及Era／Am的变化。结果口服缬沙坦3个月后，二尖辩环舒张早期峰值运动速度（Em）明显增加（P〈0．01）。结论缬沙坦能改善向心性重构型原发性高血压患者左室整体舒张功能。     

三尖瓣环运动速度多普勒组织成像评价下壁心肌梗塞后右室功能

目的 探讨多普勒组织成像(DTI)记录三尖瓣环运动速度评价下壁心肌梗塞后右室功能的价值。方法 急性下壁心肌梗塞病人28例，年龄匹配的健康者20例，于心尖四腔观三尖瓣环相对应的右室游离壁记录收缩期峰值速度(VS)，舒张早期峰值速度(VE)，舒张晚期峰值速度(VA)。结果 急性下壁心肌梗塞组三尖瓣环收缩期峰值速度、舒张早期峰值速度均降低。结论 多普勒组织成像测定三尖瓣环运动速度可作为评价下壁心肌梗塞后右室功能的新方法。     

Longitudinal ventricular function: normal values of atrioventricular annular and myocardial velocities measured with quantitative two-dimensional color Doppler tissue imaging.

OBJECTIVE: Quantitative 2-dimensional color Doppler tissue imaging is a new method to reveal impairment of left ventricular (LV) and right ventricular (RV) longitudinal function, which is a potential marker of early myocardial disease. The aim of this study was to obtain normal values for atrioventricular annular and regional myocardial velocities using this method. METHODS: A total of 123 healthy patients (age range: 22 to 89 years) underwent echocardiography including color Doppler tissue imaging using a scanner (Vivid 5, GE Vingmed, Horten, Norway) with postprocessing analysis (Echopac 6.3, GE Vingmed). Regional myocardial velocities were measured at 12 LV segments in 3 apical views and 2 segments of the free RV wall. Mitral annular velocities from 6 sites, and tricuspid annular velocities at its lateral site, were also assessed. At each site, systolic (S(m)), early diastolic (E(m)), and late diastolic (A(m)) velocities were measured, and the E(m)/A(m) ratio was calculated. RESULTS: Patients were classified into 4 groups aged 20 to 39, 40 to 59, 60 to 79, and >/=80 years. Mitral annular velocity and regional LV myocardial S(m) and E(m) progressively decreased with age. A(m), whereas low in the youngest age group, increased significantly in patients more than 40 years of age. The E(m)/A(m) ratio gradually declined with aging. There were no differences between age groups in S(m) measured at the tricuspid annulus and free RV wall, but the pattern of age-related changes of diastolic velocities and E(m)/A(m) ratio was the same as in the LV. Slight but significant sex-related differences were observed in middle-aged groups. The intraobserver and interobserver reproducibility was highest for atrioventricular annular velocities. CONCLUSIONS: A progressive decrease in S(m) reveals a decline in longitudinal systolic LV function with age, whereas systolic RV function remains unaffected. Atrioventricular annular velocity and regional E(m) decrease with aging in both ventricles, suggesting a deterioration in the diastolic properties of the myocardium, whereas A(m) increases from middle age implying a compensatory augmentation of atrial function. The study results can be used as reference data for the quantitative assessment of longitudinal LV and RV function in patients with cardiac disease.     

定量组织速度成像评价二尖瓣置换术后左心功能的临床研究

目的 探讨定量组织速度成像(QTVI)评价二尖瓣置换术(MVR)后左室整体和局部功能的临床价值.方法 80例MVR术后患者作为病例组,根据心律分为窦性心律组40例和心房颤动(房颤)组40例.常规超声心动图检查后采集心尖四腔观、心尖两腔观、心尖左室长轴观的组织多普勒动态图像,启动QTVI模式,绘制左室各壁瓣环、心肌节段的时间-速度曲线.测量收缩期峰值速度(Sa、Sm)和快速舒张期峰值速度(Ea、Em)等.结果 ①与正常组比较,MVR组6个壁二尖瓣环和各心肌节段Sa、Sm和Ea、Em均明显减低(P<0.001);②二尖瓣环收缩期平均峰值速度(Sa')与左室射血分数(LVEF)呈正相关(P<0.001);③二尖瓣环快速舒张期平均峰值速度(Ea')与等容舒张期时间均值(IVRT')呈负相关(P<0.01).结论 QTVI能够评价MVR术后左室整体和局部的收缩与舒张功能,具有重要的临床价值.

Abstract：

Objective To evaluate the clinical value of quantitative tissue velocity imaging (QTVI) in assessing left ventricular(LV) global and regional myocardial function in patients with mitral valve replacement(MVR).Methods Eighty patients having their implantations for more than six months were examined by echocardiography.QTVI-derived parameters such as peak systolic velocity(Sa,Sm) and early diastolic velocity(Ea,Em) of mitral annulus and LV wall were measured from the apical four-chamber,two-chamber and long axis corresponding myocardial segments in MVR groups decreased and LV ejection fraction but negative correlation between Ea' and isovolumic relaxation time(IVRT') in patients(P<0.01).Conclusions QTVI plays an important role in determining LV function of patients after MVR accurately.     

组织速度成像技术评价肥厚型心肌病右室舒张功能的临床研究

目的应用组织速度成像技术（TVI）评价肥厚型心肌病（HCM）患者右室舒张功能。方法对HCM患者及对照组分别测量舒张期三尖瓣口的血流峰值速度E峰、A峰,并计算E／A;应用脉冲组织多普勒测量三尖瓣隔叶及前叶瓣环处舒张早期峰值速度（Em）、舒张晚期峰值速度（Am）及Em／Am．并对两种检测方法和各组测值进行比较。结果HCM组较对照组三尖瓣E峰减低,A峰增高,E／A〈1,三尖瓣环Em减低,Am增高,Em／Am〈1;HCM组与对照组比较有显著性差异（P〈0．05）。结论组织速度成像技术能够反映HCM患者右室舒张功能的变化。     

Right ventricular diastolic abnormalities in rheumatoid arthritis and its relationship with left ventricular and pulmonary involvement. A tissue Doppler echocardiographic study

Objectives To investigate right ventricular diastolic function in rheumatoid arthritis (RA) and its relationship with left ventricular and pulmonary involvement.Methods Thirty-five RA patients and 30 healthy subjects were submitted to conventional Doppler (CE) and tissue Doppler echocardiography (TDE) to assess left and right systolic and diastolic function and to estimate maximal arterial systolic pulmonary pressure (PAP). To detect pulmonary involvement, pulmonary function tests and high-resolution computed tomography (HRCT) scans were performed in all RA patients.Results An abnormal RV filling, as expressed byan inverted tricuspid (Tr.) E/A ratio, was detected in 12 (34%) of the 35 RA patients and in 2 (7%) of the 30 controls (P<0.004). If compared to CE findings, prevalence of RV diastolic abnormalities were found higher in patients with RA by TDE (RV annulus Em/Am ratio <1 (in 31 (89%) of 35 patients) (P = 0.002). Twenty-two (63%) of 35 patients had abnormal HRCT findings. Pulmonary involvement with pulmonary hypertension (PHT) (36±5 mmHg) was detected in 10 (29%) of 35 RA. In this group, increase of RV annulus and basal Am wave, decrease of Tr. E/A ratio and RV annulus Em/Am ratio were statistically significant compared to RA (12 (34%) of 35) patients with pulmonary involvement who had normal PAP (19±5 mmHg), (P = 0.014, P = 0.006, P = 0.015, P = 0.049, respectively).Conclusions This study points out an impaired RV filling in a significant part of RA patients without overt heart failure. Impairment of RV diastolic function may be a predictor of subclinic myocardial and pulmonary involvement in patients with RA.     

组织多普勒超声测量二尖瓣环运动速度评价左室舒张功能

目的：用组织多普勒技术测定二尖瓣环舒张期运动速度评价左室舒张功能,方法;对８０全空和进行门控血池造影后３小时的３０例心肌梗患者的舒张期二法瓣环运动速度进行测量,分别在心尖四腔切面和二腔切面上测量二法瓣环间隔处,侧壁处、前壁处及后壁处的各位点舒张早期运动速度峰值Ｅｍ、舒张晚期运动速度峰值Ａｍ及二者的比值Ｅｍ／Ａｍ,并计算各点处的平均值。结果：１．心梗患者各位点的Ｅｍ测值及Ｅｍ／Ａｍ比值较正常对照组明     

组织多普勒成像评价急性心肌梗死患者自体骨髓干细胞移植治疗后左室舒张功能

目的应用组织多普勒成像(TDI)技术评价心肌干细胞移植治疗急性心肌梗死对左室舒张功能的影响。方法自体骨髓干细胞移植治疗急性心肌梗死患者共26例,随访3个月,治疗前、后用TDI技术分别测量左室二尖瓣环水平的收缩期峰值速度(Sm),舒张早期峰值速度(Em),舒张晚期峰值速度(Am)及Em/Am,并与血流多普勒指标E峰速度(E),A峰速度(A)、E/A及E峰减速时间(EDT)进行比较,评价自体骨髓干细胞移植治疗急性心肌梗死对左室舒张功能的影响。结果治疗后EDT较治疗前降低(P<0.05),治疗后Em及Em/Am较治疗前升高(P<0.05),治疗后E、A、E/A、Sm、Am较治疗前比较差异无统计学意义。结论自体骨髓干细胞移植治疗急性心肌梗死后,左室舒张功能明显改善,TDI技术在评价左室舒张功能方面较二尖瓣血流频谱更准确、敏感。     

The relation between quantitative right ventricular ejection fraction and indices of tricuspid annular motion and myocardial performance.

BACKGROUND: Assessment of right ventricular (RV) function remains challenging because of complex RV chamber geometry and a paucity of easily derived and objective functional methods. METHODS: Visual 2-dimensional echocardiographic estimates of RV ejection fraction (EF), tricuspid annular plane systolic excursion, Doppler tissue imaging, and myocardial performance index (MPI) were compared with biplanar Simpson's rule RV EF in 101 consecutive patients. Data were analyzed using simple linear regression and receiver operating characteristic curves. RESULTS: RV EF was significantly correlated with tricuspid annular plane systolic excursion (r = 0.48, P <.0001), Doppler tissue imaging peak systolic velocity (r = 0.45, P <.0001), and MPI (r = -0.38, P =.006). Using a Simpson's RV EF < 50%, the sensitivity, specificity, and positive and negative predictive values of tricuspid annular plane systolic excursion < 1.5 cm were 59%, 94%, 71%, and 89%; of Doppler tissue imaging peak systolic velocity < 10 cm/s were 59%, 92%, 67%, and 89%; and of MPI < 0.40 were 100%, 35%, 29%, and 100%, respectively. The area under the receiver operating characteristic curves was similar for the 3 indices. CONCLUSIONS: Measurements of tricuspid annular motion are easy to obtain, correlate with Simpson's RV EF, and have a high specificity and negative predictive value for detecting abnormal RV systolic function; and the MPI, although not specific, has high sensitivity and negative predictive value for detecting abnormal RV systolic function.     

Right ventricular diastolic filling assessed by conventional doppler and tissue Doppler imaging in normal children

To examine age-related changes in right ventricular filling dynamics, we performed conventional pulsed Doppler (n=99) and tissue Doppler (n=30) echocardiographic studies in normal subjects aged 7 days to 273 months. The tricuspid flow velocity during early diastole (peak E) wave correlated significantly but weakly with the logarithm of age. The peak E wave in the early neonatal period was almost 80% of the older children's values and increased to 100% by 36 months of age. In the right ventricular tissue Doppler imaging, the peak myocardial velocity during early diastole also increased significantly with the logarithm of age. However, the tissue Doppler peak A did not change with age. There was a significant correlation between the tissue Doppler peak E wave and the tricuspid peak E wave and between the tissue Doppler peak E/A wave and the tricuspid peak E/A wave. The age-related changes in the tricuspid inflow velocity patterns were similar to the age-related alterations in the right ventricular myocardial velocity patterns. Age-related changes in the tricuspid inflow velocity and myocardial velocity patterns may be related to age-related maturation in the right ventricular diastolic performance.     

Effect of pacing-induced ventricular dyssynchrony on right ventricular function

Background: Asynchronous electrical activation induced by right ventricular (RV) pacing can cause several abnormalities in left ventricular (LV) function. However, the effect of ventricular pacing on RV function has not been well established. We evaluated RV function in patients undergoing long‐term RV pacing. Methods: Eighty‐five patients and 24 healthy controls were included. After pacemaker implantation, conventional echocardiography and strain imaging were used to analyze RV function. Strain imaging measurements included peak systolic strain and strain rate. LV function and ventricular dyssynchrony by tissue Doppler imaging (TDI) were assessed. Intra‐ and interobserver variabilities of TDI parameters were tested on 15 randomly selected cases. Results: All patients were in New York Heart Association functional class I or II and percentage of ventricular pacing was 96 ± 4%. RV apical induced interventricular dyssynchrony in 49 patients (60%). LV dyssynchrony was found in 51 patients (60%), when the parameter examined was the standard deviation of the time to peak myocardial systolic velocity of all 12 segments greater than 34 ms. Likewise, septal‐to‐lateral delay ≥65 ms was found in 31 patients (36%). All echocardiographic indexes of RV function were similar between patients and controls (strain: ?22.8 ± 5.8% vs ?22.1 ± 5.6%, P = 0.630; strain rate: ?1.47 ± 0.91 s^?1 vs ?1.42 ± 0.39 s^?1, P = 0.702). Intra‐ and interobserver variability for RV strain was 3.1% and 5.3%, and strain rate was 1.3% and 2.1%, respectively. Conclusions: In patients with standard pacing indications, RV apical pacing did not seem to affect RV systolic function, despite induction of electromechanical dyssynchrony. (PACE 2011; 34:155–162)     

奥美沙坦酯胶囊对高血压右房功能影响的超声研究

目的应用二维及脉冲组织多普勒（PW-TDI）超声心动图、声学定量（AQ）技术评价奥美沙坦酯胶囊（口服8周）对高血压患者右房功能的影响。 方法对照组20例，高血压组50例。服用奥美沙坦酯前及服药8周后，测量舒张期三尖瓣口血流频谱E波、A波峰值流速，计算E／A比值。应用PW-TDI技术测量三尖瓣环附于右室侧壁处的舒张早、晚期运动速度（分别为Em、Am），计算Em／Am比值。应用AQ技术，测量RV、PFR代表右房储存器功能，REF、PRER及PRER／PAER代表右房管道功能，AEF、PAER代表右房助力泵功能。 结果与对照组比较，高血压组Em／Am＜1，E／A＜1；右房RV和PFR增高（P值均＜0．01）；PRER／PAER减低（P＜0.01）；PAER增高（P＜0.01）。药物治疗后Em／Am、E／A比值均升高（P值均＜0．001）；右房PFR显著减低（P＜0．01）。 结论高血压患者左室肥厚及右室舒张功能异常的进展导致右房功能异常，降压治疗可改善右房功能。