Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Advances in studies of phospholipids as carriers in skin topical application

Objective： This article provides an overview of characteristics of phospholipids, the characteristics and influential factors of liposome and microemulsion as carriers for skin delivery of drugs, and the latest advances of the phospholipids carriers in transdermal delivery systems. The perspective is that phospholipids carriers may be capable of a wide range of applications in the transdermal delivery system.     

Clinical analysis of neurological system complications in AIDS and HIV positive patients

Objective：To report the clinical manifestations of AIDS with nervous system complications. Methods：We collected the clinical material of AIDS and HIV positive patients who were admitted to our hospital from January 1998 to July 2006, and retrospectively analyzed the 39 cases having nervous system complications, among 146 cases in total. Results：Among 39 cases, there were 3 cases of HIV dementia, 1 case of vacuolar myelopathy, 3 cases of Gullain-barre syndrome, 3 cases of myopathy and 26 cases of secondary opportunistic infection of CNS,including 9 cases of tuberculosis, 6 cases of cryptococcus, 5 cases of toxoplasma, 3 cases of herpes zoster virus, 2 cases of herpes simples virus, 1 case of cytomegalovirus, 1 case of progressive multifocal leukoencencephalitis. 2 cases with central nervous system lymphoma.Among them 12 patients gave up treatment, other patients received anti-HIV treatment and antimicroorganism treatment. 5 patients died of respiratory failure, 2 patients died of multiple organs failure. Conclusion：Up to now, AIDS still has not very good management. So prevention is very important.     

正常生育者与不育者精液、血清、头发中锌、铜、铁含量的测定及其意义的探讨

本文测试了53例正常生育男子与92例不育男子的精液、血清、头发中锌、铜、铁的含量,发现不育男子的精锌低于正常生育者,发锌与男子生育或不育无相关性,根据精液无精子的患者其精锌值不低于正常生育者的测试结果,提出精子密度与精锌值无相关性,并提出精液液化差与液化不全或前列腺炎症常是促使精锌降低的原因等看法。不育男子的精液、血清、头发中铜、铁的含量均高于正常生育者应予以重视。     

上颌前牙宽度、前牙弓周长与前牙弓深度的相关性研究

目的:分析上颌前牙近远中宽度在上颌前牙弓周长中所占的比例关系,分析上颌前牙弓宽度不变时,前牙近远中宽度以及前牙弓周长随前牙弓深度改变而变化的规律,为前牙数字化、个性化美学分析提供可靠依据。方法:在北京大学口腔医院修复科完成修复的寄存模型中选择上颌前牙牙列完整且排列整齐的模型61副,其中男性模型22副,女性模型39副。使用单反相机固定放大比例从牙合面拍摄模型,利用Photoshop软件测量照片中前牙近远中宽度、前牙弓宽度、前牙弓深度,计算上颌前牙近远中宽度在上颌前牙弓周长中所占的比例。利用Photoshop图层自由变换功能在保持上颌前牙弓宽度不变的情况下,改变上颌前牙弓深度,测量不同凸度下上颌前牙弓的周长,按照原有各个前牙在前牙弓周长中所占的比例计算出不同凸度下各上颌前牙牙冠近远中宽度。用SPSS 23.0统计软件分析上颌前牙近远中宽度在上颌前牙弓周长中所占的比例关系,以及改变上颌前牙弓深度后上颌前牙近远中宽度的变化规律。结果:上颌中切牙、侧切牙、尖牙在上颌前牙弓一半周长所占比例分别为36.2%±1.3%、30.2%±1.5%、33.6%±1.4%,各比例为正态分布,与上颌前牙弓周长不相关。当上颌前牙弓宽度不变,在5 mm范围内,上颌前牙近远中宽度及前牙弓周长变化与前牙弓深度变化呈正相关,前牙弓深度每增加或减少1 mm,中切牙近远中宽度增加或减少约0.18 mm,半侧前牙弓周长增加或减少约0.50 mm。结论:上颌前牙近远中宽度在上颌前牙弓周长中所占比例保持稳定,在一定范围内,当上颌前牙弓宽度不变时,上颌前牙近远中宽度及上颌前牙弓周长与前牙弓深度呈正相关。     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.     

YAG激光对脑,心,肝,肾损伤作用的组织学观察

本文用10、12、15、20W Nd∶YAG激光分别照射12只正常家兔的脑、心、肝、肾区皮肤光照后5h内取相应脏器作组织病理学切片,光镜观察。结果表明:10W照射组,其脑、心、肝、肾所受间接辐射的损伤均不明显;12W照射组,其损伤也不甚明显,仅表现蛛网膜充血,脑组织轻微水肿,心肌细胞浊肿,肝细胞排列紊乱,肝窦变窄;15、20W组,各脏器均受到程度不同的损伤,尤以20W组损伤严重,脑组织出血、坏死,部分脑组织碎裂,多种炎细胞浸润,神经细胞及胶质细胞退变。心肌纤维呈波浪状改变,横纹消失,部分肌纤维断裂,间质血管扩张、充血。肝脏出现局限性、凝固性坏死区,嗜酸性增强,并有多灶性出血。肾曲小管呈颗粒样变性。所观察脏器中,以脑组织所受损伤最重,其次是肝、心、肾。     

Recent advancement on autoantigens, autoantibodies and inflammatory cells in subepidermal autoimmune bullous diseases

Subepidermal autoimmune bullous diseases （SABD） are some autoimmune skin diseases that can present in a variety of forms and can be a challenging disease to treat. An overview of the different forms of SABD are discussed including bullous pemphigoid （BP）, epidermolysis bullosa acquisita （EBA）, cicatricial pemphigoid （CP）, bullous systemic lupus erythematosus （BSLE）, and Anti-p200 pemphigoid. Emphasis on recent advancement is presented. In recent years, improved knowledge of the mechanisms of intercellular and cell-matrix adhesion has led to better understanding of the blistering process in some SABD. Defects of such structures cause the subepidermal bullous diseases and have also led to the discovery of new diseases （e.g. anti-p200-pemphigoid）. Recent studies have outlined the important role of autoantibodies, mast cell lymphocytes and their cytokines in pathogenesis of SABD.     

INTRATHYMIC INOCULATION OF LIVER SPECIFIC ANTIGEN ALLEVIATES LIVER TRANSPLANT REJECTION

Objective To study the effects of liver specific antigen (LSA) on liver allotransplantation rejection. Methods Orthotopic liver transplantation was performed in this study. Group Ⅰ: syngeneic control (Wistar-to-Wistar); Group Ⅱ: acute rejection (SD-to-Wistar). Group Ⅲ: thymic inoculation of SD rat LSA day 7 before transplantation. The observation of general condition and survival time, rejection grades and the NF-κB activity of splenocytes were used to analyze severity of acute rejection and immune state of animals in different groups. Results The general condition of group Ⅰ was fair post transplantation with no sign of rejection. All recipients of group Ⅱ died within days 9 to 13 post transplantation with median survival time of 10.7 ±1.37 days. As for group Ⅲ, 5 out of 6 recipients survived for a long period with remarkably better general condition than that of group Ⅱ. Its rejection grades were significantly lower than group Ⅱ (P＜ 0.05).NF-κB activity was only detected in group Ⅰ between days 5 and 7 after transplantation, whereas high activity of NF-κB was detected at all points in group Ⅱ and low NF-κB activity was detected in group Ⅲ which was significantly lower than that of group Ⅱ (P ＜ 0.05). Conclusions LSA is an important transplantation antigen directly involved in the immunorejection of liver transplantation. Intrathymic inoculation of LSA can alleviate the rejection of liver allotransplantation,grafts survive for a period of time thereby, allowing a novel way to liver transplantation immunotolerance.     

NP方案与XD方案治疗应用蒽环类药物治疗失败的乳腺癌的疗效观察

目的 观察诺维本联合顺铂(NP方案)与多西紫杉醇联合希罗达(XD方案)治疗应用蒽环类药物治疗失败的乳腺癌的疗效及不良反应.方法 将64例应用蒽环类药物治疗失败的乳腺癌患者随机分为两组,NP组34例,治疗方法:NVB25 mg/m2,静脉输注,第1、8天;DDP25 mg/m2,静脉输注,第2、3、4天.每21 d为1个治疗周期.XD组30例,治疗方法:DOC 75 mg/m2,静脉输注,第1天;XELODA 1275 mg/m2,口服,每日2次,第1～14天.两组均以21 d为1个治疗周期,每例至少完成2个周期.结果 NP方案总有效率(41.2%)与XD方案总有效率(50.0%)差异无统计学意义(P>0.05);两组不良反应均以粒细胞减少、恶心呕吐为主,经对症处理后可耐受.结论 NP方案与XD方案对治疗应用蒽环类药物治疗失败的乳腺癌患者均有较好疗效,可选择应用.