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正2019年12月以来,武汉市部分医院陆续发现多例不明原因肺炎病例,现已证实为2019新型冠状病毒(2019-novel coronavirus, 2019-nCoV)引起的肺炎,称为新型冠状病毒肺炎(corona virus disease 2019, COVID-19)。COVID-19诊疗方案指出"患者常存在焦虑恐惧情绪,应当加强心理疏导"。为了缓解COVID-19患者的心理压力,提高心理免疫力,增强战胜疫情的信心,国家卫生健康委员 相似文献
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新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)在全球暴发流行,危害严重。虽然目前临床研究和尸检结果提高了人们对COVID-19的认识,但仍存在诸多争议,最大的争议之一即为重症COVID-19是否可诊断为急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)。重症COVID-19符合ARDS柏林标准,但与其他原因导致的ARDS存在诸多不同之处,包括发病晚、部分患者肺顺应性相对正常、高碳酸血症出现较早、肺CT表现和肺凝血活化明显。目前对COVID-19相关ARDS的分型多基于观察性研究,偏倚较大。至今其病理生理过程尚未明确,过早分型可能误导机械通气策略,期待大样本临床研究结果带来更多证据。 相似文献
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2019新型冠状病毒(2019-nCoV)是引起武汉新型冠状病毒肺炎(COVID-19)大爆发的一种病毒,其通过病毒外膜上的棘突蛋白(S蛋白)与血管紧张素转换酶2 (ACE2)受体结合而感染人体。COVID-19患者临床症状表现为高热、呼吸困难和肺部毛玻璃样病变。COVID-19轻症患者可出现"炎症因子风暴",继而导致病程急变甚至死亡。目前,对于COVID-19治疗缺乏特异治疗方法。本文梳理了最近关于2019-nCoV的文献,从流行病学、病毒学及医学、机制学的角度全面剖析2019-nCoV的特点,为目前的COVID-19疫情的有效控制提供参考。 相似文献
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《实用医院临床杂志》2020,(2)
2019年武汉新型冠状病毒肺炎(Novel coronavirus pneumonia,NCP,即Corona Virus Disease-2019,COVID-19)是继严重急性呼吸综合征(severe acute respiratory syndrome coronavirus,SARS)、中东呼吸综合征(Middle East Respiratory Syndrome,MERS)之后严重威胁人类生命健康的呼吸道传播性疾病,三者的病原体同属β类冠状病毒,但新型冠状病毒的传染性远较SARS-CoV和MERS-CoV强,引起世界卫生组织的高度重视,并宣布其构成国际关注的突发公共卫生事件。虽然COVID-19病死率较低,但由于缺乏特效药物,仍面临巨大的治疗挑战。干扰素(IFN)具有广谱抗病毒作用,对多种冠状病毒具有明显的抑制作用。国家卫生健康委员会发布的新型冠状病毒肺炎诊治方案(试用版)中多次提出试用IFN-α雾化吸入治疗COVID-19。本文将从IFN类型、作用机理、雾化治疗机制、现有IFN治疗冠状病毒感染的证据入手,对IFN-α雾化治疗COVID-19进行综述。 相似文献
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2019年12月开始由新型冠状病毒(SARSCoV-2)感染的新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)疫情在我国快速蔓延,其主要经呼吸道传播,主要累及呼吸系统,但亦可累及全身脏器,现报道1例COVID-19合并以严重黄疸为主要表现的肝损害患者。 相似文献
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马良宋凌燕王亚飞王敏纪爱芳 《医学检验与临床》2021,(5):42-46
由新型冠状病毒2019-nCoV引起的肺炎(COVID-19)目前疫情仍十分严峻。2019-nCoV的核酸检测是COVID-19确诊的必要指标之一。临床对标本类型的选择影响2019-nCoV核酸检出率。本文报道3例COVID-19患者的确诊经过,分析采用咽拭子和痰标本检测2019-nCoV的效果,为临床诊断COVID-19时如何选择标本类型和如何提高核酸检出率提供参考。 相似文献
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Mei-Wen Han Ming Wang Meng-Ying Xu Wei-Peng Qi Peng Wang Dong Xi 《World Journal of Clinical Cases》2021,9(3):528-539
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has posed a serious threat to global public health security. With the increase in the number of confirmed cases globally, the World Health Organization has declared the outbreak of COVID-19 an international public health emergency. Despite atypical pneumonia as the primary symptom, liver dysfunction has also been observed in many clinical cases and is associated with the mortality risk in patients with COVID-19, like severe acute respiratory syndrome and Middle East respiratory syndrome. Here we will provide a schematic overview of the clinical characteristics and the possible mechanisms of liver injury caused by severe acute respiratory syndrome coronavirus 2 infection, which may provide help for optimizing the management of liver injury and reducing mortality in COVID-19 patients. 相似文献
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自2019年12月份以来,2019 新型冠状病毒(2019 novel coronavirus,2019-nCoV)肺炎在武汉局部爆发,波及全国,蔓延世界。该疾病传染性较强,虽此病以轻症为主,但仍有一定死亡率,尽管世界各国都采取相应措施,但是COVID-19感染者数量仍然持续增加,疫情形势依然严峻,截止2月26日全国累计确诊78191人,死亡2718人,在目前及以后需要手术治疗的患者中难免会有COVID-19感染者,但是外科医护及相关人员在积极救治患者的同时自身防护非常重要,因手术导致医护交叉感染的发生应避免发生。为规范脊柱外科患者合并这一新发传染病的诊治,特制订上海市公共卫生临床中心关于“脊柱外科患者合并COVID-19感染”的诊疗建议方案。 相似文献
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Rong-Yue Wang Ke-Qiong Zheng Bo-Zhong Xu Wei Zhang Jin-Ge Si Chong-Yong Xu Hua Chen Zhang-Ye Xu Xin-Mei Wu 《World Journal of Clinical Cases》2020,8(23):6016-6025
BACKGROUNDSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered coronavirus that has generated a worldwide outbreak of infections. Many people with coronavirus disease-2019 (COVID-19) have developed severe illness, and a significant number have died. However, little is known regarding infection by the novel virus in pregnant women. We herein present a case of COVID-19 confirmed in a woman delivering a neonate who was negative for SARS-CoV-2 and related it to a review of the literature on pregnant women and human coronavirus infections.CASE SUMMARYThe patient was a 36-year-old pregnant woman in her third trimester who had developed progressive clinical symptoms when she was confirmed as infected with SARS-CoV-2. Given the potential risks for both the pregnant woman and the fetus, an emergency cesarean section was performed, and the baby and his mother were separately quarantined and cared for. As a result, the baby currently shows no signs of SARS-CoV-2 infection (his lower respiratory tract samples were negative for the virus), while the mother completely recovered from COVID-19.CONCLUSIONAlthough we presented a single case, the successful result is of great significance for pregnant women with SARS-CoV-2 infection and with respect to fully understanding novel coronavirus pneumonia. 相似文献
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Zhang-Ren Chen Jing Liu Zhi-Guo Liao Jian Zhou Hong-Wei Peng Fei Gong Jin-Fang Hu Ying Zhou 《World Journal of Clinical Cases》2021,9(19):4990-4997
Coronavirus disease 2019 (COVID-19), caused by the infection of a novel coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)], has become a pandemic. The infection has resulted in about one hundred million COVID-19 cases and millions of deaths. Although SARS-CoV-2 mainly spreads through the air and impairs the function of the respiratory system, it also attacks the gastrointestinal epithelial cells through the same receptor, angiotensin converting enzyme 2 receptor, which results in gastroenteric symptoms and potential fecal-oral transmission. Besides the infection of SARS-CoV-2, the treatments of COVID-19 also contribute to the gastroenteric manifestations due to the adverse drug reactions of anti-COVID-19 drugs. In this review, we update the clinical features, basic studies, and clinical practices of COVID-19-associated gastroenteric manifestations. 相似文献
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新型冠状病毒肺炎(COVID-19)是因感染2019新型冠状病毒引起的以肺部炎性病变为主的急性呼吸道感染性疾病,其传染性强,潜伏期长。目前确诊COVID-19的金标准是核酸检测阳性,而部分患者核酸检测结果呈假阴性,且需排查患者数量较大。对于无症状患者及大量待筛查者,影像学检查尤为重要。本文围绕CT及超声检查辅助诊断COVID-19的要点及其优势和防护规范进行综述。 相似文献
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Andrew Xanthopoulos Angeliki Bourazana Grigorios Giamouzis Evangelia Skoularigki Apostolos Dimos Alexandros Zagouras Michail Papamichalis Ioannis Leventis Dimitrios E Magouliotis Filippos Triposkiadis John Skoularigis 《World Journal of Clinical Cases》2022,10(28):9970-9984
An outbreak of coronavirus disease 2019 (COVID-19) occurred in December 2019 due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a strain of SARS-CoV. Patients infected with the virus present a wide spectrum of manifestations ranging from mild flu-like symptoms, cough, fever and fatigue to severe lung injury, appearing as bilateral interstitial pneumonia or acute res piratory failure. Although SARS-CoV-2 infection predominantly offends the respiratory system, it has been associated with several cardiovascular complications as well. For example, patients with COVID-19 may either develop type 2 myocardial infarction due to myocardial oxygen demand and supply imbalance or acute coronary syndrome resulting from excessive inflammatory response to the primary infection. The incidence of COVID-19 related myocarditis is estimated to be accountable for an average of 7% of all COVID-19 related fatal cases, whereas heart failure (HF) may develop due to infiltration of the heart by inflammatory cells, destructive action of pro-inflammatory cytokines, micro-thrombosis and new onset or aggravated endothelial and respiratory failure. Lastly, SARS-CoV-2 can engender arrhythmias through direct myocardial damage causing acute myocarditis or through HF decompensation or secondary, through respiratory failure or severe res piratory distress syndrome. In this comprehensive review we summarize the COVID-19 related cardiovascular complications (acute coronary syndromes, myocarditis, HF, arrhythmias) and discuss the main underlying pathophysiological mechanisms. 相似文献
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Arunkumar Krishnan James P Hamilton Saleh A Alqahtani Tinsay A Woreta 《World Journal of Clinical Cases》2021,9(1):8-23
The outbreak of coronavirus disease-2019 (COVID-19, previously known as 2019 nCoV) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Wuhan City, China, has spread rapidly around the world. Most patients from the first cluster had an epidemiological connection to the Wuhan's Huanan Seafood Wholesale Market. Available evidence has shown that SARS-CoV-2 can be easily transmitted from person to person through close contact and respiratory droplets, posing a substantial challenge to public health. At present, the research on SARS-CoV-2 is still in the primary stages. However, dexa-methasone and remdesivir are appeared to be promising medical therapies. Still, there is no definite specific treatment, and the mainstay of treatment is still focused on supportive therapies. Currently, over 150 vaccines are under investigation. It is necessary to understand the nature of the virus and its clinical characteristics in order to find effectively manage the disease. The knowledge about this virus is rapidly evolving, and clinicians must update themselves regularly. The present review comprehensively summarizes the epidemiology, pathogenesis, clinical characteristics, and management of COVID-19 based on the current evidence. 相似文献