共查询到19条相似文献,搜索用时 328 毫秒
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环烯醚萜类化合物的研究进展 总被引:8,自引:0,他引:8
以近5 a来国内外发表的文献为依据,从结构分类和生物活性两方面综述环烯醚萜类化合物的研究进展.环烯醚萜类化合物结构繁多,具有多种生物活性. 环烯醚萜化合物具有很高的研究价值. 相似文献
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10批栀子中环烯醚萜苷类成分含量测定 总被引:2,自引:0,他引:2
目的 测定不同产地的10批栀子药材中栀子苷、京尼平龙胆二糖苷及总环烯醚萜苷含量。方法 采用HPLC测定栀子苷、京尼平龙胆二糖苷含量;采用紫外分光光度法测定总环烯醚萜苷含量。结果 江西产栀子中环烯醚萜苷类成分含量高。结论 不同产地栀子药材中环烯醚萜苷类成分含量有所差别。 相似文献
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目的 优化独一味总环烯醚萜苷的制备工艺,获取纯度相对较高的总环烯醚萜苷。方法 以甲醇-水为流动相,梯度洗脱方式建立分离分析独一味总环烯醚萜苷的高效液相色谱方法,实现各组分的最佳分离,统计、记录其三维吸收图谱,并结合紫外全波长扫描,对前期制备的独一味总环烯醚萜苷中影响纯度的杂质特征进行分析,根据杂质特性优化大孔树脂结合聚酰胺柱制备过程,紫外实时监测,剔除杂质,产品溶液经冷冻干燥获得冻干粉,并以HPLC对比前后制备工艺产品成分差异。结果 工艺优化前产品中环烯醚萜苷含量为69.06%,优化后含量为90.60%,含量提升21.54%;本次制备总产率为16.70%(以水提取物的质量为参照),总环烯醚萜苷转移率为74.72%(相对于水提取物中总环烯醚萜苷的质量)。结论 优化过程简单,操作步骤可控,易于实现,纯化效果显著。 相似文献
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目的 优化恩施巴戟中主要环烯醚萜苷类成分提取工艺,评价恩施巴戟体外抗氧化活性。方法 选择经典的加热回流提取法,以乙醇体积分数、溶剂倍量、提取时间为考察因素,以浸膏得率和水晶兰苷含量的综合评分为评判指标,设计正交试验筛选最佳提取工艺条件;测定总还原能力、DPPH清除率、羟自由基清除率,检测其体外抗氧化活性。结果 最佳提取工艺条件为6倍量的60%的乙醇加热回流2 h;恩施巴戟具有一定的抗氧化能力,乙酸乙酯部位活性最佳。结论 优化的提取工艺稳定可行,可用于提取恩施巴戟的环烯醚萜苷类成分,该研究初步证明了恩施巴戟具有一定的抗氧化活性。 相似文献
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目的 比较白毛夏枯草饮片及其2种复方汤剂的次生代谢产物含量与抑菌活性的相关性,为合理配伍提供依据。方法 采用牛津杯琼脂扩散法测定抑菌圈大小,利用分光光度法测定次生代谢产物(总黄酮、总皂苷、环烯醚萜类和总生物碱)含量,并进行抑菌活性相关性和通径分析,确定目标化合物。结果 总黄酮、总皂苷和环烯醚萜类含量:复方1>复方2>单方,总生物碱含量:复方2>单方≈复方1。2种复方抑菌强度基本相同且显著高于单方,4种次生代谢产物对金黄色葡萄球菌的抑菌活性均起正相关作用,总环烯醚萜直接通径系数最大。结论 白毛夏枯草复方次生代谢产物含量和抑菌活性均高于单方,影响其抑菌活性的成分主要是环烯醚萜类与皂苷类。 相似文献
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以国内外文献为依据,对从黄蝉属植物中报道的化学成分进行了整理和综述,介绍黄蝉属化学成分研究概况,为其进一步开发利用提供参考。成分类别主要为环烯醚萜(iridoid)和木脂素(lignan)类,所发现的化合物分别为环烯醚萜24个,木脂素9个,其他类别成分较少。其中环烯醚萜类内酯成分黄蝉花定(Allamandin)、鸡蛋花素(plumericin)等的生物活性显示有抗肿瘤、抗真菌作用。 相似文献
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Yong-Chao Li Jing Yang Xing-Gang Wu Xin-Juan Xu Qing-Yun Fu 《Journal of Asian natural products research》2013,15(8):788-792
Three new iridoids, cornifins A–C (1–3), together with a known iridoid, were obtained from EtOAc layer of leaves of Cornus officinalis. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses. Compound 2 showed weak inhibitory activity against lung cancer cell line A-549 with IC50 value of 29.1 μM. 相似文献
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《Expert opinion on therapeutic patents》2013,23(12):1323-1347
Introduction: Coumarins belong to the benzopyrones family. They are naturally plant-derived and synthetically taken polyphenolic substances, presenting a wide variety of biological activities and behaviours, supporting their use as therapeutic agents for multiple diseases. Their structural characteristics correlated to physicochemical properties seem to define the extent of the biological activity.Areas covered: Recent patent publications (2012 – 2014), describing coumarins and their derivatives are analyzed. Synthesis, hybridization techniques and biological evaluation in vitro/in vivo, for example, antimitotic, antiviral, anticancer, cytotoxic, anti-acne and antioxidant coumarin macromolecule polymer agents are included. Furthermore, a wide range of pharmaceutical applications and pharmaceutical compositions are also summarized.Expert opinion: Several natural and synthetic coumarins, hybrids and derivatives appear to have promising anticancer-antitumor activities. Their clinical evaluation will be critical to assess therapeutic utility. The compounds for which the mechanism of action is well defined can serve as lead compounds for the design of new more potent molecules. 相似文献
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From the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Russelia equisetiformis, one new iridoid glucoside was isolated along with 24 known compounds, comprising iridoids and iridoid glucosides, phenyl
propane glucosides, phenyl ethanoids, lignan glucosides, and flavonoid glucosides. The structure of the new compound was elucidated
to be 10-O-cinnamoyl sinuatol. Of the 25 compounds isolated, rehmaglutin B exhibited moderate inhibitory activity toward NO production,
which was not associated with cytotoxicity. 相似文献
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Six new compounds, an iridoid glucoside, 6- O-methyl-epiaucubin, three iridoids, artselaenins A, B, C, a phenylethanoid glycoside, artselaeroside A, and a phenylpropanoid glycoside, artselaeroside B, as well as fourteen known compounds, nine iridoid glycosides and five phenylpropanoid glycosides were isolated from the whole plants (including roots, stems, leaves and flowers) of Pedicularis artselaeri. Their structures were identified mainly by spectral evidence. 相似文献
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《Expert opinion on drug discovery》2013,8(7):549-560
Introduction: Rhodanine-based compounds have been associated with numerous biological activities. After many years of research in drug discovery, they have gained a reputation as being pan assay interference compounds (PAINS) and frequent hitters in screening campaigns. Rhodanine-based compounds are also aggregators that can non-specifically interact with target proteins as well as Michael acceptors and interfere photometrically in biological assays due to their color. Areas covered: The authors review the recently reported biological activities of rhodanine-based compounds. Furthermore, the article provides details of their synthesis and occurrence in compound libraries through high-throughput screening (HTS) and virtual high-throughput screening (VHTS). Additionally, the authors provide the reader with possible mechanisms of non-specific target modulation, analysis of the crystal structures of enzyme–rhodanine complexes and a comparison of rhodanine and thiazolidine-2,4-dione moieties. Expert opinion: The biological activity of compounds possessing a rhodanine moiety should be considered very critically despite the convincing data obtained in biological assays. In addition to the lack of selectivity, unusual structure–activity relationship profiles and safety and specificity problems mean that rhodanines are generally not optimizable. 相似文献
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Two new non-glycosidic iridoids, which were named cachinol (1) and 1-O-methyl cachinol (2), were isolated from the methanol extract of the leaves of Campsis grandiflora together with a known iridoid cachineside I (3). The structures of compounds 1 and 2 were determined on the basis of spectroscopic methods including two dimensional NMR and high resolution mass spectrometry. All of the isolated compounds showed mild inhibitory activities on rat platelet aggregation. Compounds 1 and 3 (IC50 : 246 and 219 microM, respectively) showed about 2-fold higher inhibitory effects than acetylsalicylic acid (ASA, IC50: 412 microM) on collagen-induced aggregation. Compounds 1 and 2 (IC50: 43.2 and 38.4 microM, respectively) were about 2-fold more inhibitory than ASA (IC50: 75.2 microM), and about 4-fold more effective than their glycoside 3 (IC50: 189 microM) on AA-induced aggregation. 相似文献
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Enzyme inhibitory activities of 14 iridoids previously obtained from two Malaysian medicinal plants, Saprosma scortechinii and Rothmannia macrophylla, were evaluated in vitro using soybean lipoxygenase and bovine testis hyaluronidase. Most of the iridoids, including asperulosidic acid, paederosidic acid, and an epimeric mixture of gardenogenins A and B, did not show any effect on the enzyme activities, except for the bis-iridoids, which inhibited the lipoxygenase activity with their IC(50) values of approximately 1.3 times that of a known inhibitor, fisetin. Structural modification of asperulosidic acid and paederosidic acid through enzymatic hydrolysis by beta-glucosidase resulted in their inhibition towards the enzyme activities, and these activities were enhanced by the presence of some amino acids (lysine, leucine or glutamic acid) or ammonium acetate. Mixtures of gardenogenins A and B; isomers of non-glucosidic iridoids, incubated with amino acid or ammonium acetate did not show any inhibitory effect on the enzyme activities during the 6 h incubation period, except for lysine where spontaneous reaction between the iridoids and amino acid resulted in the inhibition of lipoxygenase activity. The results from these biomimetic reactions suggested that the iridoid aglycons and the intermediates formed by these reactive species could inhibit the enzyme activities, and thus substantiate previous reports that the formation of iridoidal aglycons is a prerequisite for the iridoid glycosides to demonstrate some of the biological activities. In addition, the results also indicated that it is worthwhile to further explore these intermediates as potential anti-inflammatory agents. 相似文献
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《Expert opinion on therapeutic patents》2013,23(10):1575-1596
Introduction: Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family that possess a wide variety of cytoprotective and modulatory functions, which may have therapeutic potential for multiple diseases. Their physicochemical properties seem to define the extent of their biological activity. Areas covered: A comprehensive synopsis of recent patent literature (2005 – 2011) describing chalcones and their derivatives on selected activities (e.g., anti-inflammatory, antimitotic, cytotoxic, antioxidant, anti-infection) is provided in this paper. Synthesis, combinatorial techniques, biological evaluation in vitro/in vivo, and new biological assays are discussed. In addition to selected biological data, a wide range of pharmaceutical applications and pharmaceutical compositions are also summarized. Expert opinion: Several natural and synthetic chalcones and their derivatives appear as promising anti-inflammatory and anticancer activities. Their clinical evaluation will be critical to assess their therapeutic utility. Those for which the mechanism of action is well defined can serve as lead compounds for the design of new, more promising molecules. 相似文献