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本文概述了大数据的概念,讨论了利用大数据推进药品"智慧监管"的议题,为药品监管部门提高监管效率提供参考。从药品生产、流通、使用等环节系统分析了大数据在我国药品监管领域的应用现状。国家、省级药品监管、检验单位以及生产企业都在积极探索大数据在药品监管中的应用,出现了许多效果明显的实例,但大数据的建设和应用方面还存在诸多问题。针对这些问题,本文提出了相应的解决方案。药品监管部门需完善顶层设计,建设药品监管大数据中心,整合各系统资源,采用"合成作战"模式,同时加快相关法律法规及政策的出台,形成善用"大数据"成就药品智慧监管的新局面。 相似文献
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食品与药品是人们日常生活中的基本需求,食品与药品安全与人们的身体健康有密切关系.近年来,食品药品的安全问题受到人们的广泛关注.气相色谱技术是一项常规的检测技术,具有应用广泛、准确性高、灵敏度高等特点,可为食品药品安全提供有力保障.本文阐述了气相色谱仪在食品药品检测中的应用和气相色谱仪的维护方式,为气相色谱在食品药品检测... 相似文献
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目的 了解山西省食源性致病菌的污染现状.方法 按照2010年度《全国食源性致病菌监测工作手册》进行.结果 1 576份样品中共检出阳性菌株149株,检出率为9.45%,其中单核细胞增生李斯特氏菌、副溶血性弧菌污染比较严重,总检出率为9.50%和8.22%,金黄色葡萄球菌、阪崎肠杆菌和沙门氏菌的总检出率分别为3.02%、1.11%和0.87%.不同类别食品中致病菌的检出率差异较大,生肉中致病菌的检出率高居榜首为49.33%,主要污染菌为沙门氏菌、单核细胞增生李斯特氏菌;沙拉中致病菌的检出率为17.39%,主要污染菌为单核细胞增生李斯特氏菌、金黄色葡萄球菌;生食水产品中致病菌的检出率为16.94%,主要污染菌为单核细胞增生李斯特氏菌、副溶血性孤菌;熟肉制品中致病菌的检出率为9.84%,主要污染菌为单核细胞增生李斯特氏菌、金黄色葡萄球菌、沙门氏菌;中式凉拌菜中致病菌的检出率为8.89%,主要污染菌为金黄色葡萄球菌;鲜榨果汁中致病菌的检出率为6.67%,主要污染菌为金黄色葡萄球菌;鲜冻水产品中致病菌的检出率为5.00%,主要污染菌为副溶血性弧菌;婴幼儿配方粉/米粉/谷粉/豆奶粉中阪崎杆菌的检出率为1.11%.结论 山西省多种食品均存在食源性致病菌不同程度的污染,应加大对散装食品、即食食品和生食水产品的监管. 相似文献
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One hundred and forty-six samples of animal feed (barley, n = 60; wheat bran, n = 22; wheat dry pulp, n = 29; and canola meal, n = 35) were collected in 2011 from Mashhad (Khorasan, Iran). Aflatoxins (AFs) were determined in these samples after immunoaffinity column clean-up by high-performance liquid chromatography (HPLC) with fluorescence detection. Aflatoxin B1 (AFB1) contamination was found in 28 samples: in five of the barley samples (8.3%) at a mean level of 0.48 µg·kg?1, in two wheat bran samples (9.0%) at a mean level of 0.88 µg·kg?1, in 10 wheat dry pulp samples (34.5%) at a mean level of 0.30 µg·kg?1 and in 11 canola meal samples (31.4%) at a mean level of 0.92 µg·kg?1. AFB1 levels were below the maximum levels of Iran regulations (5 µg·kg?1) and the EU maximum limit (5 µg·kg?1). 相似文献
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食品中的亲电物质是高效低毒的核转录因子NF-E2相关因子2(Nrf2)诱导剂,通过Keap1/Nrf2/ARE通路激活Ⅱ相酶和抗氧化酶的转录。Ⅱ相酶和抗氧化蛋白可发挥慢速、长效的抗氧化和解毒作用。目前已经发现食品中有9类亲电物质,它们具有相似的结构特征。研究和开发食品中的亲电物质,将成为功能性食品新的研究领域。 相似文献
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转录组测序技术能将组织或细胞在不同生理条件下的差异基因量化,是探索基因功能和揭示特定生物学过程中分子机理的必要手段。储粮害虫是严重危害储藏粮食的一类害虫,从转录组水平揭示储粮害虫生长发育、关键基因功能、抗药性分子机制等成为研究热点,极大促进了对储粮害虫特别是无参考基因组信息的害虫的研究。因此,本文系统性从生长发育相关基因的挖掘、组织特异性基因、与微生物互作机制、对环境胁迫的响应机制、磷化氢抗性机理和植物精油杀虫机理研究六个方面综述了转录组学在储粮害虫研究中的应用,旨在为储粮害虫的深入研究提供参考,对进一步进行储粮害虫防治技术开发提供理论依据。 相似文献
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Aflatoxins (AFs) are highly toxic, and carcinogenic secondary fungal metabolites and have been detected in various food commodities. In this regard, 40 black tea samples including domestic and imported black tea were analysed for aflatoxin contamination by high-performance liquid chromatography using a post-column derivatisation procedure (Kobra cell) with fluorescence detection. Samples were randomly collected in 2010 from Tehran markets. The results revealed that 30 among 40 samples were contaminated with aflatoxins (27.5% of the total). Mean AFB1 content was 10.0 ng/g and mean of aflatoxin total was 12.07 ng/g for the 11 contaminated samples. 相似文献
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Tareq M. Osaili Abbas F. Al Jamali Ibrahim M. Makhadmeh Mohammad Taha Sukiena K. Jarrar 《Food Additives and Contaminants: Part B: Surveillance Communications》2016,9(3):223-229
Heavy metals (As, Cd, Co, Cr, Cu, Mn, Ni, Pb and Zn) in various vegetables (cabbage, green onion, lettuce, parsley, rocket, spinach, carrot, onion, potato and cauliflower) from the market in Jordan were measured using inductively coupled plasma-mass spectrometry. As, Cd, Co, Cr, Cu, Mn, Ni, Pb and Zn ranged from 0.009–0.275 mg kg?1 wet weight, 0.004–0.060 mg kg?1, 0.003–0.401 mg kg?1, 0.105–3.51 mg kg?1, 0.15–1.15 mg kg?1, 0.93–14.39 mg kg?1, 0.044–0.702 mg kg?1, 0.072–0.289 mg kg?1 and 2.23–6.65 mg kg?1, respectively. Parsley, followed by spinach, contained the highest concentration of heavy metals. Onion contained high levels of toxic heavy metals. The content of Cu in parsley and spinach and Pb in onion exceeded the Codex limits. However, the daily intake of heavy metals from the tested vegetables was lower than the maximum limits for allowable intake. 相似文献