早期诊断乳腺疾病——细针针吸细胞学的价值

目的：探讨细针针吸细胞学（FNAC）检查诊断乳腺疾病在临床中的应用价值。方法：对2025例乳腺肿块进行细针针吸细胞学检查,其中565例有病理组织学对照的进行综合分析。结果：细针针吸细胞学检查与组织学符合率98.5%,灵敏度（真阳性率）96.2%,特异性（真阴性率）96.6%。结论：细针针吸细胞学检查对诊断乳腺肿块性质存在一定程度的假阳性和假阴性,但其敏感性和特异性均较高,在临床中有很重要的应用价值。     

132例乳腺肿块针吸细胞学诊断与病理组织学诊断对比分析

目的比较乳腺肿块针吸细胞学检查在临床中的应用价值。方法分析132例乳腺肿块针吸细胞学诊断,并与术后病理组织学诊断结果相对比。结果针吸细胞学检查良性病变101例,乳腺癌31例,其中肯定为癌者29例,疑为癌2例,阳性率为93.9%,假阴性诊断2例,占6.1%,无假阳性报告。结论乳腺肿块针吸细胞学在乳腺肿块良恶性病变的鉴别中具有较高的应用价值。     

乳腺肿物针吸细胞学与组织学对比观察

目的 针吸细胞学作为临床乳腺肿块定性诊断的方法，具有独特的实用价值，但存在假阴性病例。本文旨在提高其诊断准确率，减少假阴性的发生。方法 本文对64例经手术病理组织学证实的针吸细胞学检查乳腺肿物的病例进行细胞学与组织学对比观察。结果 恶性肿瘤56例，细胞学检查确诊36例，可疑12例，符合率85．7％，假阴性8例，占14．3％。良性肿瘤8例，无假阳性。结论 乳腺癌针吸细胞学检查阳性率与其组织学类型有关，但技术因素是影响针吸细胞学诊断阳性率的主要因素，其中包括：抽吸技术、涂片技术及诊断技术。     

针吸细胞学诊断对乳腺癌防治普查应用的探讨

目的:探讨针吸细胞学诊断对乳腺癌早期诊断、普查防治的应用价值。方法:对2578例乳腺肿瘤将针吸细胞学与病理组织切片对照分析,并结合临床资料,从细胞学角度分析乳腺肿瘤的细胞学特点。结果:2578例乳腺肿块患者FNAC与病理组织学对照,总正确率为98.7%,恶性肿瘤诊断的正确率为96.4%,良性肿瘤诊断的正确率为98.2%,假阴性率为1.1%,潜在假阳性率为1.3%,无一例假阳性。结论:乳腺肿物针吸细胞学诊断是一种患者易于接受、操作简便快速、经济、准确的诊断技术,对乳腺疾病的诊断有较高的应用价值,是乳腺癌防治普查的有效方法。     

100例乳腺肿块术前针吸细胞学检查与术后病理结果分析

目的 :对术前乳腺肿块针吸细胞学检查与术后组织病理学检查结果进行分析 ,了解其与临床的关系。方法 :随机抽出 10 0例相关住院病人进行回顾性分析。结果 :术前乳腺肿块经穿刺细胞学检查的 10 0例中术后病理证实恶性肿瘤 91例 ,良性肿瘤 9例。恶性中 9例为假阳性 ,但其中 8例行了根治或仿根治 ;3例为假阴性。结论 :尽管针吸细胞学检查诊断乳腺肿块性质存在着一定程度的假阴性或假阳性 ,但临床上其敏感性和特异性仍均较高 ,具有相对独特意义 ,值得推广应用。     

细针吸细胞学在乳腺肿瘤诊断中的应用

我院1977～1986年共做乳腺肿块细针吸细胞学检查1250例,其中359例获病理组织可供对照分析,对照率28.7％。良、恶性肿块术前细胞学诊断符合率分别为90.8％和80.1％。细针吸细胞学检查可用于乳癌普查和在部分病例代替冰冻切片活检。假阴性率较高,且有一定假阳性和针吸失败率、细胞量过少时不能充分反映出组织学特征为其缺点。本文提出提高针吸细胞学应用价值的工作程序。     

1100例乳腺肿块细针吸取细胞学和病理组织学诊断对比分析

目的:探讨细针吸取细胞学检查乳腺肿块的准确性及临床应用价值.方法:采用10ml 7号针头一次性注射器针吸乳腺肿块4384例,其中1100例有病理组织学诊断对照.结果:细针吸取细胞学阳性确诊率92.26%,假阳性率0.27%;阴性确诊率99.19%.结论:细针吸取细胞学检查乳腺肿块准确性较高,10ml7号针头一次性注射器取材对组织损伤极小,一次取材成功率98.49%,具有较大的实用价值.     

针吸细胞学检查对乳腺肿块的诊断价值

目的:针吸细胞学作为临床乳腺肿块的定性诊断方法,具有独特的使用价值,且病理界广泛应用,但存在假阴性病例。方法:回顾自1998年以来近276例乳腺肿块细针吸取细胞学检查(FNAC),并对78例或术后病理组织学对比,组织学恶性肿瘤69例,细胞学56例,可疑11例,符合率86.9%,假阴性8例,占10.2%,良性肿瘤3例,无假阴性。结论:针吸细胞学检查对乳腺癌诊断具有方法简便、安全快捷、经济实用和诊断率高等优点,可以达到对乳腺癌的早期发现及明确诊断,但有假阴性病例存在。     

1916例乳腺肿块针吸细胞学诊断

总结１９８５￣１９９３年乳腺肿物针吸细胞学检查１９１６例。经病理组织学证实者４０７例，其中乳腺恶性病变２０４例。细胞学诊断敏感性为９２．２％，特异性为７６．０％；假阴性为７．８％。并就假阴性及假阳性出现的原因和如何提高诊断阳性率进行了讨论。     

乳腺肿块针吸细胞学检查九年总结

总结１９８５年－１９９３年乳腺肿物针吸细胞学检查１９１６例。获病理组织学证实者４０７例、其中乳腺恶性病变２０４例。细胞学诊断敏感性为９２．２％，特异性为７６．０％，假阴性为７．８％，并就假阴性及假阳性出现的原因和如何提高诊断阳性率进行了讨论。     

1731例乳腺肿块细针穿刺诊断的临床应用分析

目的：探讨乳腺肿块细针穿刺细胞学检查（FNAC）的临床应用价值。方法：对2006～2010年的1 731例乳腺肿块细针穿刺细胞学检查结果进行对比分析。结果：1 731例乳腺细针穿刺病例,2009～2010年的病例及阳性病例明显高于2006～2008年,其中924例做了活检对照,恶性肿瘤敏感性为96.68%（233/241）,假阴性率为3.32%（8/241）,无假阳性。FNAC诊断的总准确率为97.29%（899/924）。结论：乳腺肿块细针穿刺诊断技术,操作简易、快速、安全、可靠、价格低廉,可在基层医院及乳腺癌筛查中大力推广。     

Fine-needle aspiration cytology in the management of breast disease

The results of a series of fine needle aspiration biopsies of breast lumps were reviewed to evaluate the accuracy of this diagnostic method and its place in the clinical management of breast lesions. A high level of diagnostic accuracy was achieved. There were no false positive diagnoses of malignancy and fewer than 3% of diagnoses were falsely negative. Eighty per cent of carcinomas could be confidently diagnosed by means of cytological investigation. The patient with a benign cytological diagnosis can either be reassured, or her surgical management planned as a day case. For the patient with a cytological diagnosis of malignancy, discussion of the nature of her surgery and subsequent care is possible before operation. In selected cases of carcinoma, mastectomy can be performed without frozen-section confirmation. Diagnostic accuracy is dependent upon experience, especially in aspiration technique, and optimum results are obtained if the pathologist/cytologist also performs the procedure.     

端粒酶活性检测在乳腺癌诊断中的意义

[目的 ]探讨细针穿刺乳腺肿瘤组织的端粒酶活性检测在乳腺癌诊断中的意义 .[方法 ]用聚合酶链反应 酶联免疫吸附测定法检测 79例术前乳腺肿瘤细针穿刺活检标本和大体标本的端粒酶活性 ,并与病理诊断进行比较 .[结果 ]乳腺癌 6 5例中穿刺组织端粒酶呈阳性的为 5 7例 ,阳性率为 88% ;大体组织端粒酶呈阳性的为 5 4例 ,阳性率为 83% .淋巴结转移者端粒酶活性高于无淋巴结转移者 .乳腺良性疾病 14例中端粒酶呈阳性的为 2例 ,阳性率为 14 % .[结论 ]术前乳腺肿瘤穿刺组织的端粒酶活性检测有利于乳腺肿瘤的早期诊断及鉴别诊断 .     

The experience with fine needle aspiration cytology in the management of palpable breast lumps in the University Hospital Kuala Lumpur

A total of 676 palpable breast lumps seen in the Breast Clinic, University Hospital, Kuala Lumpur from August 1993 to August 1994 were subjected to fine needle aspiration cytology. Fifty-four were reported as inadequate, 501 benign, 95 malignant and 26 suspicious. One hundred and eighty-seven aspirates had histological correlation, while 34 of the malignant aspirates had clinical correlation. The majority of the other 455 patients were followed up for a period of 60 to 72 months without any malignancies becoming apparent. For analysis, only the 221 cases with histological or clinical correlation were included, (the suspicious category was included into the positive group and the inadequate cases were excluded), giving a sensitivity of 91.7%, a specificity of 91.7% and a diagnostic accuracy of 91.7%. Breast cytology was an accurate and rapid method of diagnosis of breast diseases, and in a busy surgical unit with limited operating time, it allowed for the triage of patients with breast complaints in deciding which cases needed early open biopsy. A negative cytology does not exclude the possibility of cancer, as there was a false negative rate of 11%. However by utilising a diagnostic triad of clinical examination, radiological assessment and fine needle aspiration cytology, the risk of missing a malignancy is small.     

细针穿刺与麦默通在 T1期乳腺癌术前诊断中应用比较

目的：探讨细针穿刺与麦默通在 T1期乳腺癌术前诊断中的效果,为乳腺癌的诊断提供依据。方法：选择本院2012年4月-2015年4月收治的有手术指征并确诊的 T1期乳腺癌患者130例进行分析,所有患者术前均进行细针穿刺与麦默通微创活检系统进行检查,观察两组检查方法的优缺点。结果：在一次性确诊 T1期乳腺癌的实际效果和准确性上,麦默通活检显著优于细针穿刺检查,差异具有统计学意义;且麦默通穿刺成功率及穿刺阳性率均显著高于细针穿刺,差异有统计学意义;但麦默通穿刺后皮下血肿及皮下淤血发生率显著高于细针穿刺,差异有统计学意义。结论：细针穿刺法简便、安全、创伤小,缺点为阳性率较低、漏诊率较高;而麦默通穿刺法具有高敏感、高特异性、微创的优点,故麦默通微创活检系统是乳腺肿块定性困难（包括细针穿刺检查阴性）时的一个安全、有效的诊断方法。     

细针吸取活检细胞学在乳腺癌诊断中的应用

目的：探讨细针吸取活检细胞学对乳腺癌的诊断价值。方法：以术后病理诊断为对照（１３４例）,光镜下观察５２１例乳腺肿瘤的针吸涂片。结果：在５４例乳腺癌中,细胞学诊断正确者４９例（９０．７％）,可疑者４例（７．４％）,假阴性者１例。同期细胞学诊断为乳腺癌者未见假阳性。结论：细针吸取活检对乳腺癌的定性和分级诊断均准确可靠。     

乳腺肿块细针吸取细胞学与术中冰冻切片诊断比较

目的：分析乳腺肿块细针吸取细胞学(FNAC)与术中冰冻切片诊断(IFSD)的不同特征，探索两者的临床应用价值。方法：对乳腺肿块205例分别进行FNAC和IFSD检查。结果：乳腺良性病变FNAC和IFSD的准确率分别为96．4％和98．6％，乳腺恶性肿瘤FNAC和IFSD的准确率分别为91．0％和97．0％。FNAC假阴性率为2．4％，无假阳性诊断；IFSD未出现假阴性和假阳性诊断。结论：乳腺肿块FNAC和IFSD检查是两种实用、可靠的诊断方法。     

A 3 year audit of fine needle aspirates from a symptomatic breast clinic.

A total of 2431 fine needle aspirates of symptomatic breast lumps was performed on 2096 patients over the last three years at the weekly head, neck and breast clinic at the Belfast City Hospital Trust. Diagnostic accuracy was achieved within the recommended standards although the "insufficient" rate was high at 31.8%. False negative and positive rates were low and the positive predictive value for malignancy was 99%. Excision biopsy for benign breast disease had decreased by almost a third during this period. Fine needle aspiration cytology is a highly accurate and cost-effective technique for the investigation of symptomatic breast lumps and results in significant savings.     

Diagnosis of breast lump by fine needle aspiration cytology and mammography

Breast carcinoma is the most common malignant tumour and the leading cause of death from cancer in women. A large number of patients in Bangladesh have been suffering from breast cancer. Now-a-days, Fine needle aspiration cytology (FNAC) is being performed as a pre-operative test to evaluate breast lump. FNAC is cost effective and can prevent unnecessary surgery. As FNAC became more reliable in diagnosing malignancy and thereby the use of frozen-section histology had been reduced by about 80%. But erroneous diagnosis is more common with FNAC than with histopathology. However, mammography can identify breast cancers too small to palpate on physical examination and theoretically beneficial to diagnose even noninvasive lesions. Present study aimed to see the accuracy of FNAC and mammography in the diagnosis of palpable breast lumps and to study their correlation. In this study 222 patients were included in the study and FNAC was done in all the patients. Mammography was done in 112 cases. Among these 112 patients 32 cases were found malignant. Histopathology was done in total 89 cases. Among 112 patients who were underwent mammography only 43 were found for histopathology. Finally, 36 cases were found malignant. Fibroadenoma is mostly found in below 20 years group and malignancy is mostly occurring in older age group. Mammography shows total 8 false positive and 5 false negative cases. FNAC shows only 1 false positive and 1 false negative case. On analysis mammography showed 82.76% sensitivity, 90.36% specificity, 75% Positive predictive value (PPV), 93.75% Negative predictive value (NPV) and 88.39% accuracy. FNAC showed 97.22% sensitivity, 99.46% specificity, 97.220% PPV, 99.46% NPV and 99.095% accuracy. Mammography was found to be less sensitive, specific and accurate in the diagnosis of breast lump though there is highly significant correlation among them. However, the study has shown a much higher performance of FNAC than other previous studies indicating the improved skill in cytological diagnosis to a satisfactory level.