新生儿缺氧缺血性脑病血清甲状腺激素变化

目的 :探讨新生儿缺氧缺血性脑病 (HIE)甲状腺激素的变化及临床意义。方法 :采用放射免疫分析法对6 0例HIE病人进行血清甲状腺激素测定 ,同时设对照组。结果 :本组病例血清T3 、FT3 值明显低于对照组 ;中～重度组低于轻度组 ,两组比较有显著差异。中～重度组不仅血清T3 、FT3 水平明显降低 ,而且T4 也可降低。本组病例低T3 综合症、低甲状腺血症、高T4 综合症 (中～重度组无 1例 )发生率分别为 6 8 6 3%、11 6 7%、3 33%。结论 :本病血清甲状腺激素的变化与病情的轻重程度密切相关 ,可作为判断疾病的严重程度及预后的实验室指标。     

窒息新生儿血清游离甲状腺激素变化及其临床意义

目的 探讨窒息新生儿血清游离甲状腺激素的变化及临床意义.方法 对40例窒息新生儿(窒息组,其中轻度窒息19例,重度窒息21例)及40例同期出生的正常新生儿(对照组)于生后24 h内及1周抽取股静脉血送检血清游离甲状腺激素(FT3、FT4)、促甲状腺激素(TSH).结果 生后24 h内窒息组FT3、FT4均明显低于对照组(P＜0.01),重度窒息患儿FT3、FT4均低于轻度窒息患儿(P＜0.05),窒息组和对照组间TSH差异无显著性(P＞0.05).1周后复查FT3、FT4、TSH,窒息组与对照组差异无显著性(P＞0.05).结论 新生儿窒息可出现暂时性低甲状腺素血症,且随窒息程度加重而加重,随原发病好转甲状腺功能可自行恢复,无需特殊治疗.     

窒息新生儿甲状腺功能变化研究

目的　研究新生儿窒息后甲状腺功能的变化。方法　对 6 3例窒息新生儿、30例足月正常新生儿及 6 0例正常儿童检测T3 、T4、FT3 、FT4及TSH ,并复查窒息组异常者 ,直到正常为止。结果　与对照组相比 ,轻度窒息组T3 、FT3 降低 (P <0 .0 5 ) ,T4、FT4、TSH无显著变化 (P >0 .0 5 ) ;重度窒息组T3 、FT3 、T4、FT4明显降低 (P <0 .0 1) ,TSH升高 (P <0 .0 5 )。 4 8例甲状腺功能异常者中 32例在出生 13d内恢复正常 ,其水平与儿童正常值无明显差异 (P >0 .0 5 )。出生 2 5d内甲状腺功能全部恢复正常。结论　新生儿窒息可致甲状腺功能一过性减低 ,且其减低与窒息程度呈正相关。     

窒息新生儿甲状腺功能状态临床分析

目的:探讨新生儿窒息后甲状腺功能的变化及临床意义.方法:对51例足月窒息新生儿和35例对照组足月新生儿于生后3天抽取静脉血,用化学发光免疫分析法测定甲状腺功能,即血清T3、T4、TSH、FT3、FT4,并进行比较观察.结果:窒息新生儿血清T3、T4、TSH、FT3、FT4均低于正常对照组,差异有非常显著性意义(P＜0.01),且以重度窒息组为甚;TSH则无明显差异.结论:新生儿窒息后可出现甲状腺功能低下,而且甲状腺素降低程度与窒息严重程度呈正相关,适量使用甲状腺素治疗有利于疾病的恢复和减少并发症.     

围产期新生儿窒息并低钠血症分析

目的 :探讨围产期窒息新生儿血清钠变化情况。方法 :监测 72例窒息新生儿生后 2 4h内及 72h血清钠浓度并与对照组比较。结果 :重度窒息组血清钠浓度为 (1 2 2 4 8± 9 6 3)mmol L ,与轻度窒息组(1 33 72± 7 4 1 )mmol L比较 ,t =2 2 5 6 ,P <0 0 5。轻、中、重度HIE组患儿血清钠浓度分别为 (1 31 34±5 2 2 )mmol L、(1 2 5 6 8± 9 5 7)mmol L、(1 1 4 35± 7 89)mmol L。中度与轻度之间比较t =2 381 ,P <0 0 5 ;重度与轻度之间比较t =3 2 4 9,P <0 0 1。结论 :窒息既可导致HIE ,又可引起低钠血症 ,而严重低钠血症又可能加重缺氧缺血性脑损伤 ,窒息尤其是重度窒息患儿应对血清钠离子进行动态监测 ,以及早发现 ,及时治疗 ,改善预后     

窒息新生儿甲状腺功能测定及临床意义

目的：探讨新生儿窒息后血清甲状腺激素的变化及其临床意义。方法：采用放射免疫法对50例窒息新生儿（轻度窒息组24例，重度窒息组26例）和40例正常新生儿（对照组）脐带血及生后3d静脉血中甲状腺激素三碘甲状腺原氨酸（T3）、促甲状腺激素（T4）及总甲状腺素（TSH）水平进行测定，对各组问及组内脐血、静脉血T3、T4、TSH水平进行比较。结果：（1）轻、重度窒息组新生儿生后3d静脉血T3、T4水平明显低于对照组（P〈0．01），而脐血及生后3d静脉血TSH水平均明显高于对照组（P〈0．01），并且重度窒息组生后3d静脉血TSH水平升高更明显（P〈0．01）。（2）生后3d静脉血和脐血自身前后对比，对照组T3、T4水平明显升高，TSH无明显改变，轻、重度窒息组T3、T4水平虽有下降，但差异无统计学意义（P〉0．05），而TSH水平则下降明显（P〈0．01）。结论：新生儿窒息后可出现甲状腺功能低下，血清甲状腺激素可作为窒息新生儿病情判断、疗效观察及预后估计的一项参考指标。     

新生儿窒息患儿血清胆红素水平变化分析

目的　分析新生儿窒息患儿血清胆红素水平变化及其影响因素。方法　收集 4 3例窒息新生儿 (重度组1 0例 ,轻度组 33例 ) ,以同期出生的正常足月新生儿 30例为对照组 ,分别在胆红素高峰期 (生后 4～ 5天 )进行股静脉穿刺抽血测血清胆红素水平。结果　重度窒息组血清胆红素水平显著低于轻度组 (P <0 .0 1 ) ,轻度组显著低于对照组 (P <0 .0 1 )。结论　窒息后新生儿血清胆红素水平明显降低 ,且窒息越严重 ,血清胆红素水平越低。     

新生儿败血症甲状腺激素变化及临床意义探讨

目的 :探讨新生儿败血症甲状腺激素变化及临床意义。方法 :观察组 14例新生儿败血症 ,2 1例健康新生儿为对照组。应用放射免疫分析法测定其血清甲状腺激素 (T3 、T4 ) ,游离甲状腺激素 (FT3 、FT4 ) ,促甲状腺激素 (TSH)水平 ,结果进行t检验。结果 :观察组与对照组血清T3 、T4 、FT3 、FT4 之间差异显著 ,FT3 、FT4 差异非常显著 ,各组间TSH均无显著差异。结论 :新生儿败血症可有甲状腺功能改变 ,游离激素变化显著。血清甲状腺激素水平测定可作为机体代谢状况判定、疗效观察和预后估计的一项实验依据。     

老年充血性心力衰竭患者血清甲状腺激素的变化及其临床意义

目的:探讨充血性心力衰竭(CHF)患者血清甲状腺激素及促甲状腺激素水平的变化及其临床意义。方法:用放射免疫法测定60例CHF患者血清三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、游离T3(FT3)、游离T4(FT4)、促甲状腺激素(TSH)的变化,并与38例正常对照组进行比较。经治疗后54例好转,其中46例复查上述参数。结果:轻度CHF患者甲状腺激素无明显变化;重度CHF患者T3明显降低,心衰越重变化越明显,T4、FT3、FT4、TSH无明显变化;心衰减轻后T3明显升高。结论:血清T3水平的改变对判断CHF严重程度、治疗效果和预后有一定的指导意义。     

新生儿缺血缺氧性脑病的血清肌酸激酶脑型同工酶和甲状腺激素水平变化的临床观察

目的探讨新生儿缺血缺氧性脑病（HIE）患儿血清肌酸激酶脑型同工酶（CK-BB）和甲状腺激素水平变化及临床意义。方法63例HIE新生儿分成轻度组、中度组和重度组,58例正常新生儿作为对照组。测定HIE组和健康对照组入院24小时内与入院1周后的血清T3、T4、TSH水平与CK-BB,同时分析HIE组血清T3、T4水平与CK-BB之间的相关性。结果HIE组血清T3、T4水平显著低于健康对照组（P〈0.01）,并随着HIE的严重程度而降低（r=0.85,p〈0.01）,与CK-BB成负相关（r=-0.79,P〈0.01）。结论HIE新生儿血清中T3、T4水平与HIE程度密切相关,HIE程度越重其水平越低。血清T3、T4水平与CK-BB水平存在相关性,可作为对新生儿HIE的早期诊断、病情严重程度判定的常用指标;对临床进行干预治疗和早期估计预后具有重要的意义。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.