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1.
Fas (CD95)andFasligand (FasL) ,asmembersofTNFfamilies ,aretypeⅠandtypeⅡcellulartransmembraneproteins FasLinducesapoptosisbybindingtoitsreceptorFasonthecellsurface Thisprocessisinvolvedinimmuneresponsetovirus ,tumorcellsandtheregulationoflymphocytehomeostasis…  相似文献   

2.
Objective ToinvestigatetheexpressionofFas/APO1inthecourseofcellcycles-Methods Fas/APO1expressionofrenalcellcarcinoma(RCC)celllineGRC1cellssynchronizedbytwiceoverdosethymidineblocksandnitrousoxide(N2O)gaswasdetectedbymeansofflowcytometryemployingFI…  相似文献   

3.
Syntheticoligodeoxynucleotides(ODNs)representanewtoolforthediscoveryofphysiologicalmechanismsincellcultures,intissuesandinvivo.Ideally,anantisenseODNistargetedinasequence-specificman-nertonucleicacids(RNAorDNA)tooffertheexcitingpossibilityofselective…  相似文献   

4.
Oxidized low -density lipoproteins (oxLDL) have been show n to play a crucialrole in atherosclerosis, butthe underlyingm olecularm echanism s have notbeen fully understood. The presentstudy show ed thatoxLDLstrongly evoked phosphoryla-tion and activation ofp38 m itogen-activated protein kinase (MAPK) in ratvascular sm ooth m uscle cells (VSMCs) in concen-tration-and tim e-dependentm anners, reaching the m axim alactivation at100 μg/m lwithin 5 m inutes. The results from im -m unofluorescence staining also revealed thatp38 MAPK w as activated by  相似文献   

5.
Objective Toinvestigatetheeffectsofarotinoidacid(Ro13 7410 )onthemorphologicalandfunctionalalterationsofleukemiaHL 60celllineandcomparedwiththoseofRA Methods DifferentiationofHL 60cellswasassessedbymorphologyandbyNBTreduction Trypanblueexclusionwasusedtodeter…  相似文献   

6.
CytotoxicityofHumanLAKCellsAgainstMitoticPhaseTumorCellsLiuGuorong(刘国荣),LiDianjun(李殿俊);BaDenian(巴德年)andMengXiaobo(孟晓波)(Cancer...  相似文献   

7.
Thesis·AcuteEffectsofChineseHerbsonthePeritonealDialysisEfficacyandPeritonealUltrastuctureXiChunsheng ,etal.1:( 1)…………………EffectsofHaslPlusChemotherapyonPeripheralBloodTCellSubsetsandNKCellActivityinPatientswithOvarianEpithelialCarcinomaZhuGenhai,etal.1:( 3)……  相似文献   

8.
螺旋藻多糖对CD3AK细胞增殖能力的影响   总被引:3,自引:0,他引:3  
研究了螺旋藻多糖(PS)对CD3McAb激活的杀伤细胞(CD3McAb activated killer cells,CD3AK cells)增殖能力的影响。结果表明,当PS浓度为2.5μg/ml培养体系条件下,对CD3AK细胞具有明显的刺激细胞增殖作用(P〈0.02);对培养长达23d的CD3AK细胞杀伤肿瘤细胞(KL562细胞)的活性仍维持在较高的水平(46.5% ̄50%)。  相似文献   

9.
INTRODUCTION  ICAM 1alsonamedCD54,isanadhesionmoleculeonthecellularsurfaceandamemberofimmunoglobulinsuper family(1) .Inrecentyears ,alongwiththedevelopmentofimmunologyandmolecularbiologictechnique ,thestudyonICAM 1hasbeenprogressedforagreatdeal.Itisdiscov ere…  相似文献   

10.
TheInfluenceofThymectomyonGerm-cellsoftheTestisinMiceZENGJin(曾进),ZHANGYong-shang(章咏裳);S.POMER,G.STAEHLERREN;Da-hong(任大洪)(Depa...  相似文献   

11.
INTRODUCTION  Themethodofcoldliverpreservationisacruciallimit ingfactorinthedurationofliverpreservation .Experimentalevidencehasshownthatnonparenchymalcellsaremorevulnerabletohypothermicstoragethanhepatocyte,indicatingthatprotectionofthemicrovasculatur…  相似文献   

12.
BuyangHuanwuDecoction(BYHWD)isaChinesetraditonalmedicamentwhichhasbeenusedinclinicalpracticeforalongtime.ItiscomposedofrawRadixAstragalus120g,RadixAngelicaSinensis6g,RadixPaeoniaRubra4.5g,RhizomaLigusticumWallichii,SemenPersica,FlosCarthamusandLumbricus…  相似文献   

13.
TheclinicaleffectandvalueofCD3AK(CD3monoclonalantibodyactivatedkillercells)wereinvestigatedin45caseswithmiddle-advancedcancer...  相似文献   

14.
Dendriticcells (DCs)arethemostpowerfulantigen presentingcells (APCs) DCshavetheuniquecapacitytostimulatenaiveTcellstoinduceanantigen specificprimaryimmuneresponse ,whereasotherAPCscanonlyactivatealreadystimulatedTcells 1 Atthistime ,themechanismunderlyingth…  相似文献   

15.
Objective Tostudytheeffectsofarachidonicacid,linoleicacid,andkupffercellconditionedmedium(KCCM)derivedfromarachidonicacidandlinoleicacidtreatmentonproliferationofrathepaticstellatecells(HSC)-Methods HSCandkupffercellswereisolatedandculturedfromliver…  相似文献   

16.
INTRODUCTION  Graves’disease(GD)isoneoftheautoimmunethyroiddiseases(AITD) ,andischaracterizedbyhypermetabolicandhyperthyroidsyndromecausedbyTSHreceptor stimulatingantibody TheetiologyandpathogenesisofGDarestillnotfullyclarified TheroleofTcellswaswidelyst…  相似文献   

17.
OxLDL-inducedCytotoxicityandItsInhibitionbyAPI_(0134)inCulturedPorcineAorticEndothelialCellsWANGHongwei(王宏伟);ZHAOHuayue(赵华月);?..  相似文献   

18.
Objective ThetumorsuppressorgeneCDKN2A,locatedonchromosome9p21,encodesthecellcycleregulatoryproteinp16.InactivationofCDKN2Agenecouldleadtouncontrolledcellgrowth.InordertodeterminetheroleofCDKN2Ainthedevelopmentofsporadicovariancancerweexaminedlossofh…  相似文献   

19.
DetectionofHumanPapillomavirusGenesinParaffin-embeddedHumanOralSquamousCellCarcinomasbyPolymeraseChainReactionandRFLPAnalysis...  相似文献   

20.
ethods LowdensitylipoproteinwasisolatedfromnormalheparinizedbloodbydensitygradientultracentrifugationandoxidizedbyCuCl2 TotalRNAwasextractedfromhumanumbilicalveinendothelialcells (HUVECs)exposedtoLDLorOX LDL ,usingtheguanidiniumisothiocyanatemethod Thequ…  相似文献   

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