221例良性胃病中幽门螺杆菌感染与癌胚抗原表达的研究

胃镜取２２１例良性胃病的粘膜组织进行ＨＥ染色，Ｇｅｉｍｓａ染色查Ｈｐ，ＣＥＡ单克隆抗体免疫组化检查。结果：Ｈｐ感染率７７３８％（１７１／２２１），ＣＥＡ阳性率３８９１％（８６／２２１），肠化生（ＩＭ）和／或不典型增生（ＡＨ）发生率２６７％（５９／２２１），在Ｈｐ阳性与阴性病变中，ＩＭ和／或ＡＨ发生率分别为３０４１％（５２／１７１）及１４％（７／５０）（Ｐ＜００５）；ＣＥＡ的阳性率分别为４３２８％（７４／１７１）及２４％（１２／５０）（Ｐ＜００１）。提示Ｈｐ感染与胃的癌前病变的发生及ＣＥＡ的表达相关     

重型肝炎患者丙型肝炎病毒抗体的存在状态及其意义

采用合成肽酶免疫分析法（ｓｐＥＬＩＳＡ）和美国Ｏｒｔｈｏ公司第２代ＥＬＩＳＡ（２ｎｄＥＬＩｓＡ）对１０３例重型肝炎患者血清丙型肝炎病毒抗体（抗ＨＣＶ）作筛选，阳性血清用重组免疫印迹法（４·ＲＩＢＡ）作鉴定，并用逆转录聚合酶链反应检测ＨＣＶＲＮＡ，以重新评价重型肝炎患者血清抗ＨＣＶ存在状态及其意义。发现ｓｐＥＬＩＳＡ和２ｎｄＥＬＩＳＡ检测抗ＨＣＶ的阳性率分别为２２．３３％（２３／１０３）和１９．１０％（１７／８９），阳性血清经４·ＲＩＢＡ鉴定仅５９．０９％（１３／２２）阳性，ＨＣＶＲＮＡ检出率亦仅为６０．００％（９／１５）。动态观察，约１／３抗ＨＣＶ阳性患者抗ＨＣＶ持续２～４周消失。血清反复冻融可使阳性检测吸光值（Ａ４９２）下降，阴性检测Ａ４９２值升高。血清抗ＨＣＶ阳性和（或）ＨＣＶＲＮＡ阳性患者均合并乙型肝炎病毒（ＨＢＶ）感染，但合并ＨＣＶＲＮＡ阳性患者预后较差。结果提示单独ＨＣＶ感染不是本地区重型肝炎发生的主要原因，部分患者抗ＨＣＶ存在可能属既往感染或系“被动输入”所致，也可能为假阳性，检测ＨＣＶＲＮＡ对于确切了解重肝患者ＨＣＶ感染状况和判断预后有一定的意义。     

唾液抗幽门螺杆菌IgG检测诊断幽门螺杆菌感染的评价

目的 评价唾液抗幽门螺杆菌（ＨＰ）抗体诊断ＨＰ感染的价值。方法 ９３例病人同时进行唾液抗ＨｐＩｇＡ测定、快速尿素酶试验（ＲＵＴ）、组织涂片ＨＥ染色及病理ＷＳ银染色法诊断ＨＰ感染结果 唾液抗ＨｐＩｇＧ检测阳性率近似于ＲＵＴ法，高于组织涂片ＨＥ染色法和病理ＷＳ银染色法，其诊断ＨＰ感染的敏感性与９６．９７％，特异性８８．２３％，准确性９５．１８％，阳性预测值９７％，阴性预测值８８．２４％，结论唾液抗Ｈｐ     

武汉地区Ⅱ型糖尿病患者冠心病与载脂蛋白E基因型的关系

应用聚合酶链反应（ＰＣＲ）技术，对随机选择的１２５例ＮＩＤＤＭ患者和５０例非ＤＭ患者进行ＡｐｏＥ基因型检测，以研究ＮＩＤＤＭ患者ＣＨＤ与ＡｐｏＥ基因型间的关系。结果表明，ＮＩＤＤＭ患者心肌梗塞和缺血性心电图改变在Ａｐｏε４／４和ε４／３型组中发生率分别为２１％和４１％，但不同基因型组间差异无显著性。心绞痛在Ａｐｏε４／４和ε４／３型组中为５２％，显著高于ε３／３型组（３１％，Ｐ＜０．０５）。Ａｐｏε４／４和ε４／３型ＮＩＤＤＭ患者，任何证据的ＣＨＤ发生率为７２％，显著高于ε３／３型组（３７％）及ε２／２、ε３／２型组（３３％，Ｐ＜０．０１）。ＮＩＤＤＭ患者中ＣＨＤ组Ａｐｏε３／３和ε４／３基因型频率分别为５２％和３４％，分别低于（ε３／３）、高于（ε４／３）非ＣＨＤ组（７１％，Ｐ＜０．０５；１０％，Ｐ＜０．０１）；ＣＨＤ组ε４等位基因频率为２１％，明显高于非ＣＨＤ组（７％，Ｐ＜０．０１）。提示Ａｐｏε４／４和ε４／３为ＮＩＤＤＭ患者ＣＨＤ的重要危险指标。     

高原健康人和高原病患者肺血流动力学研究

目的探讨高原健康人和高原病患者肺循环血流动力学变化规律及其与高原病发病的关系。方法采用右心漂浮导管术测定高原健康人及高原病（ＨＡＤ）患者血流动力学参数１１７例，其中高原健康人２７例，急性高原反应（ＡＨＡＲ）６例，慢性高原病（ＣＨＡＤ）３１例，急性高原肺水肿（ＡＨＰＥ）５２例。结果高原健康人肺动脉平均压（ｍＰＡＰ）在正常范围内，ＡＨＡＲ、ＣＨＡＤ、ＡＨＰＥ患者ＭＰＡＰ分别为３．７３±１．４８ｋＰａ（２８．０±１１．１ｍｍＨｇ）、４．３４±１．６８ｋＰａ（３２．６±１２．６ｍｍＨｇ）、６．６５±１．５１ｋＰａ（５０．０±１１．３ｍｍＨｇ），以ＡＨＰＥ的ＭＰＡＰ最高。各型ＨＡＤ患者ＭＰＡＰ与血氧饱和度呈负相关，与肺循环阻力及右室作功指数（ＲＶＳＷＩ）呈正相关，而体循环压力改变不明显。结论认为低氧性肺动脉高压（ＨＰＡＨ）在高原健康人群中无普遍性，ＨＰＡＨ是各型高原病共有的重要病理生理改变，而轻度ＨＰＡＨ是早期高原病的征兆。     

肝细胞癌患者乙、丙和丁型肝炎病毒感染状况

为探讨乙型、丙型和丁型肝炎病毒（ＨＢＶ，ＨＣＶ和ＨＤＶ）感染对肝细胞癌（肝癌）发生的意义，本文作者采用ＥＬＩＳＡ和聚合酶链反应法对７２例广东籍肝癌患者ＨＢＶ、ＨＣＶ和ＨＤＶ血清标志以及血浆ＨＢＶＤＮＡ和ＨＣＶＲＮＡ进行了检测。ＨＢｓＡｇ和抗－ＨＣＶ阳性率分别为８４．７％和１８．１％，显著高于１２８名健康对照者。ＨＢｓＡｇ和／或ＨＢＶＤＮＡ总阳性率为９３．１％，抗－ＨＣＶ和／或ＨＣＶＲＮＡ阳性率为２７．８％，ＨＢＶ和ＨＣＶ重叠感染率为２２．２％。其中６１例ＨＢｓＡｇ阳性肝癌的ＨＤＶ血清标志检出率为１４．８％，明显高于６１例ＨＢｓＡｇ阳性的肝炎对照者。结果表明，广州地区肝癌的发生，主要与ＨＢＶ和ＨＣＶ感染密切相关外，且可能与ＨＤＶ感染有关。     

丙型肝炎抗原和乙型肝炎表面抗原在原发性肝细胞癌肝组织中的定位

用免疫组化技术对６４例原发性肝细胞癌（ＨＣＣ）癌组织进行丙型肝炎抗原（ＨＣＡｇ）和乙型肝炎表面抗原（ＨＢｓＡｇ）定位和分布的研究。结果见ＨＣＡｇ呈粗颗粒深着色，弥漫性分布于全核，部分核仁可显色。肝性细胞多数散在分布于癌组织中，少数集中分布。ＨＢｓＡｇ呈棕褐色细颗粒，分布于细胞浆和细胞膜，阳性细胞多数呈聚集性分布，少数呈散在分布。６４例ＨＣＣ癌组织中的ＨＣＡｇ阳性率为１２．５％（８／６４），ＨＢｓＡｇ阳性率为２６．５％（１７／６４）。１５例癌周组织，呈现ＨＣＡｇ或ＨＢｓＡｇ染色阳性者占６．６％，３３％。揭示ＨＣＶ在ＨＣＣ的发生中，有相当一部分以与ＨＢＶ双重感染形式存在。     

老年性痴呆患者认知功能与磁共振成像

目的观察老年性痴呆病（ＡＤ）患者临床神经心理学变化和海马体积改变相关性意义。方法对３２例ＡＤ病人行ＭＲＩ冠状位扫描，用计算机图像定量分析技术测量海马体积（ＨＰＶ）；从ＭＲＩ片上测出海马结构（ＨＦ）和脉络膜间隙（ＣＦ）结构线性比值（ＨＦ／ＣＦ）；与神经心理学检测评分进行相关性统计；同时与正常人对比。结果ＡＤ病人ＨＰＶ、ＨＦ／ＣＦ均小于对照组（Ｐ＜０．００１）。ＨＰＶ、ＨＦ／ＣＦ同侧比较均有明显相关性（ｒ＝０．７７～０８２）。两侧ＨＰＶ、ＨＦ／ＣＦ与记忆商数（ＭＱ）、简易智力测验评分也有明显相关性，尤以ＭＱ最为明显（０７５～０７８，Ｐ＜０．０１）。结论轻度ＡＤ患者即有海马结构萎缩。用简易方法直接阅ＭＲＩ片测算ＨＦ／ＣＦ，同样能够对ＡＤ病人的海马结构加以评估，可为临床诊断ＡＤ提供参考依据     

原发性肝细胞癌癌周肝组织中乙型和丙型肝炎病毒抗原？…

目的：了解乙型和丙型肝炎病毒感染与原发性肝细胞癌（ＨＣＣ）的病因学关系。方法：病例对照研究，以３９例肝硬化学伴发ＨＣＣ为测试组，４８例肝硬化为对照组，利用免疫组织化学染色观察肝组织切片中乙型（ＨＢｓＡｇ／ＨＢｃＡｇ阳性率在ＨＣＣ组（２３／３９，５８．９７％）和肝硬化组（２４／４８，５０％）之间无显著性统计学差异，ＨＢＶ和ＨＣＶ抗原同时阳性者在ＨＣＣ组（１４／３９，３５．８９％）高于肝硬化组（９／４     

丙型肝炎病毒母婴传播的研究

目的研究丙型肝炎病毒母婴传播的可能性与机率。方法采用前瞻性研究方法，使用ＰＣＲ技术检测ＨＣＶＲＮＡ，用二代ＥＩＡ试剂检测抗－ＨＣＶ。结果１３例输血后丙型肝炎母亲和她们所生的１５例婴儿，婴儿ＨＣＶ感染率为８６．７％，其中临床型１例（７．７％），亚临床型ＨＣ３例（２３．１％），ＨＣＶ隐性感染９例（６９．２％）。抗－ＨＣＶ和ＨＣＶＲＮＡ阳性率均随年龄增长而降低，至３岁时分别为７．７％和１５．４％。结论感染ＨＣＶ母亲所生婴儿，ＨＣＶ感染率高，但转归较好。观察引产胎儿肝脏和血液发现，孕妇抗－ＨＣＶ和ＨＣＶＲＮＡ阳性所引产的胎儿血清和／或肝脏中抗－ＨＣＶ和ＨＣＶＲＮＡ阳性，ＨＣＶ的母婴传播，主要发生于子宫内。     

Immunohistochemical study of colorectal adenocarcinomas and adenomas with antibodies against carcinoembryonic antigen (CEA), CA19-9, keratin, α-tubulin and secretory component (SC)

The immunohistochemical localization of five antibodies against carcinoembryonic antigen (CEA), CA19-9, keratin, α-tubulin and secretory component (SC) was investigated in 14 lesions of adenocarcinoma (AC), 22 of adenoma with high-grade atypia (AH), 50 of adenoma with low-grade atypia (AL), and 15 of non-neoplastic mucosa (NNM) of the large intestine. The positive patterns for each staining were divided into three categories (patterns 1,2, and 3). All neoplastic lesions (AC, AH and AL) were positive for CEA, while 85.7% of AC, 36.4% of AH and 6.0% of AL showed strongly positive staining (pattern 3). 78.6% of AC and 54.5% of AH were positive for CA19-9 in comparison to 20.0% of AL. For keratin, more than 95% ofthe neoplastic lesions were positive, while 78.6% of AC, 27.3% of AHand 22.0% of AL showed strongly positive staining (pattern 3). For a-tubulin, more than 85% of neoplstic lesions were positive, while 50.0% of AC, 36.3% of AH and 26.0% of AL showed strongly positive staining (pattern 3). For SC, in contrast, 42.9% of AC, 27.3% of AH and 8.0% of AL were negative, but 93.3% of NNM were positive. It was concluded that the positive staining rate, especially the rate of pattern 3 for each antibody correlated with the degree of atypia of the colorectal neoplastic lesions (AC, AH and AL).     

Immunohistochemical study of colorectal adenocarcinomas and adenomas with antibodies against carcinoembryonic antigen (CEA), CA19-9, keratin, alpha-tubulin and secretory component (SC).

The immunohistochemical localization of five antibodies against carcinoembryonic antigen (CEA), CA19-9, keratin, alpha-tubulin and secretory component (SC) was investigated in 14 lesions of adenocarcinoma (AC), 22 of adenoma with high-grade atypia (AH), 50 of adenoma with low-grade atypia (AL), and 15 of non-neoplastic mucosa (NNM) of the large intestine. The positive patterns for each staining were divided into three categories (patterns 1, 2, and 3). All neoplastic lesions (AC, AH and AL) were positive for CEA, while 85.7% of AC, 36.4% of AH and 6.0% of AL showed strongly positive staining (pattern 3). 78.6% of AC and 54.5% of AH were positive for CA19-9 in comparison to 20.0% of AL. For keratin, more than 95% of the neoplastic lesions were positive, while 78.6% of AC, 27.3% of AH and 22.0% of AL showed strongly positive staining (pattern 3). For alpha-tubulin, more than 85% of neoplastic lesions were positive, while 50.0% of AC, 36.3% of AH and 26.0% of AL showed strongly positive staining (pattern 3). For SC, in contrast, 42.9% of AC, 27.3% of AH and 8.0% of AL were negative, but 93.3% of NNM were positive. It was concluded that the positive staining rate, especially the rate of pattern 3 for each antibody correlated with the degree of atypia of the colorectal neoplastic lesions (AC, AH and AL).     

胃上皮化生、幽门螺杆菌与十二指肠溃疡关系的探讨

目的：研究胃上皮化生、幽门螺杆菌（HP）与十二指肠溃疡之间的关系。方法：应用特殊染色方法对60例十二指肠溃疡球部活检标本进行形态学观察及HP检测，并以50例正常十二指肠粘膜作对照。结果：胃上皮化生率球溃组（81．7％）高于对照组（26％）（P＜0．005）；球部HP检出率球溃组（50％）高于对照组（14％）（P＜0．005）；球部HP94．6％（35／37）生长在胃上皮化生区，5．4％（2／37）生长在无化生区（P＜0．050），轻度，中度，重度胃上皮化生区HP检出率分别为21．4％，64．3％，70．0％，中－重度胃上皮化生区HP检出率高于轻度化生区（P＜0．05）。结论：胃上皮化生与HP相继作用，形成十二指肠溃疡。     

消化性溃疡与幽门螺杆菌L型感染相关性研究

目的　探讨消化性溃疡 (PU)与幽门螺杆菌 L型 (HP- L )感染的关系。方法　取 386例 PU患者胃窦、胃体及十二指肠粘膜组织 ,常规切片后以革兰氏染色和免疫组化染色镜检 HP- L 型细菌 ,并计算检出率。结果　 HP- L 型检出率为 5 3.37% ,其中革兰氏染色和免疫组化染色检出率分别为 5 6 .73%、5 4 .2 9% ,差异无显著性(P>0 .0 5 ) ;胃溃疡、十二指肠溃疡 HP- L 型检出率分别为 5 8.33%、5 5 .5 0 % ,差异无显著性 (P>0 .0 5 ) ;男女患者HP- L 检出率前者 (6 1.18% )明显高于后者 (38.17% ) (P<0 .0 1) ;30岁以下、30岁～、4 0岁～、5 0岁～患者 HP- L检出率依次为 32 .0 5 %、4 1.94 %、5 9.18%、71.79% ,差异显著 (P<0 .0 1)。结论　 PU患者 Hp- L型感染率较高 ,且男性高于女性 ,HP- L型检出率随年龄增长而增高。 PU患者 HP- L型变异可能是导致溃疡迁延不愈、反复发作的重要原因之一     

慢性糜烂性胃炎与胃癌的免疫组织化学比较研究——P~(21ras)、 P~(53)、PCNA和CEA表达的观察

本研究对31例慢性糜烂性胃炎粘膜活检组织及14例手术切除的胃癌组织的P21ras、P53蛋白、细胞核增殖抗原（PCNA）、癌胚抗原（CEA）的表达采用LSAB免疫组织化学标记。结果发现P21ras在慢性糜烂性胃炎粘膜上皮和胃癌肿瘤细胞中表达阳性率分别为67.7％和65.0％（P>0.05）;P53表达阳性率分别为0和21.4％（0.010.05）;CEA表达阳性率分别为29.0％和78.6％（P<0.01）。慢性糜烂性胃炎较高的P21ras表达和较高的细胞增生活性（PCNA表达）,提示其有一定的转化趋势。慢性糜烂性胃炎粘膜上皮的CEA表达可能提示其为今后发展成肠型胃癌的前驱病变。     

Association of serum vascular endothelial growth factor-C and lymphatic vessel density with lymph node metastasis and prognosis of patients with gastric cancer

AIM: To investigate whether serum vascular endothelial growth factor-C (SVEGF-C), VEGF-C, and lymphatic vessel density (LVD) in tumor tissues are related to lymph node metastasis (LNM) and prognosis in gastric cancer.METHODS: SVEGF-C levels of 80 gastric cancer patients and 20 healthy donors were examined using ELISA. VEGF-C expression and LVD were examined using immunohistochemical staining. Kaplan-Meier survival analysis was performed to determine their influence on the prognosis of the patients. RESULTS: The SVEGF-C level in gastric cancer patients (595.9 ± 201.0 ng/L) was significantly higher (P = 0.000) than controls (360.0 ± 97.4 ng/L). Both SVEGF-C and LVD were significantly higher in poorly differentiated adenocarcinomas, T3 and T4, LNM, distant metastasis, and pTNM groups Ⅲ and IV (P = 0.000). The sensitivity and specificity of SVEGF-C for predicting LNM were 82.8% and 81.8%, respectively (cut-off = 542.5 ng/L). The positive expression rate of VEGF-C was significantly higher in cancerous than in normal tissues (65% vs 20%; P = 0.001). VEGF-C expression up-regulation was significantly related to differentiation, depth of invasion, LNM, distant metastasis, and pTNM stage (P = 0.000). LVD was 10.7 ± 3.1/200 HP in the experimental group vs 4.9 ± 1.3/200 HP in controls (P = 0.000); LVD in cancerous tissues with and without LNM was 12.0 ± 2.7/200 HP vs 7.6 ± 0.5/200 HP, respectively (P = 0.000). SVEGF-C and LVD were significantly higher in VEGF-C positive than in negative patients (P=0.000); SVEGF-C level was related to LVD (P = 0.000). Kaplan-Meier survival analysis factors predicating poor prognosis were: SVEGF-C level (P = 0.001), VEGF-C expression and LVD (both P = 0.000). CONCLUSION: SVEGF-C level, VEGF-C and LVD are related to LNM and poor prognosis of patients with gastric cancer. SVEGF-C may be a biomarker for LNM in gastric cancer.     

血清胃泌素-17、胃蛋白酶原联合幽门螺杆菌检测在老年人胃癌癌前病变及早期胃癌筛查中的价值

目的探讨血清胃泌素-17(G-17)、胃蛋白酶原(PG)联合幽门螺杆菌(HP)检测在胃癌癌前病变以及早期胃癌筛查中的价值。方法选取2015年1月至2019年8月我院收治的因上腹不适就诊而确诊为胃部病变的194例病人作为研究对象,其中≥60岁102例为老年组,<60岁92例为中青年组。所有病人均经胃镜及病理学检查确诊为良性病变、癌前病变或早期胃癌。比较不同病变程度病人G-17、胃蛋白酶原比值(PGR)及HP阳性率,比较不同年龄组病人的临床资料、病情,并分析HP、G-17及PGR对癌前病变及早期胃癌的诊断价值。结果老年组和中青年组良性病变病人合并胃癌家族史的比例均较癌前病变及早期胃癌病人明显降低,差异具有统计学意义(P<0.05)。老年组内良性病变病人HP检出率,G-17、PGⅡ水平较癌前病变及早期胃癌病人明显降低,PGR明显升高;中青年组内良性病变病人HP检出率较癌前病变及早期胃癌病人明显降低,差异具有统计学意义(P<0.05)。老年组和中青年组良性病变病人各项指标比较,差异均无统计学意义(P>0.05);癌前病变病人不同年龄组HP检出率,G-17、PGⅡ水平,PGR差异均有统计学意义(P<0.05);早期胃癌病人不同年龄组G-17、PGⅡ水平,PGR差异均有统计学意义(P<0.05)。ROC分析显示,HP联合G-17及PGR对老年人癌前病变、早期胃癌诊断评估的AUC(95%CI)分别为0.765(0.622~0.939)、0.757(0.654~0.876)。结论G-17、PGR及HP联合检测在老年人早期胃癌及癌前病变的筛查中具有应用价值。     

幽门螺杆菌感染和胃粘膜下血管壁iNOS的免疫组化分析

目的：研究幽门螺杆菌（HP）感染对胃粘膜下血管诱导型一氧化氮合成酶（iNOS）活性的影响。方法：40例十二指肠溃疡病人，术中取胃组织检测HP，iNOS采用免疫组化法检测。结果：HP阳性者iNOS强阳性表达率为62．6％，阴性者为23．1％（P＜0．01）。结论：HP感染可激活胃粘膜血管iNOS活性，是导致胃炎的原因之一。     

Dynamic expression of pepsinogen C in gastric cancer, precancerous lesions and Helicobacter pylori associated gastric diseases

AIM: To investigate the relationship between the expression of pepsinogen C (PGC) and gastric cancer, precancerous diseases, and Helicobacter pylori (H pylori) infection. METHODS: The expression of PGC was determined by immunohistochemistry method in 430 cases of gastric mucosa. H3 Pylori infection was determined by HE staining, PCR and ELISA in 318 specimens. RESULTS: The positive rate of PGC expression in 54 cases of normal gastric mucosa was 100%. The positive rates of PGC expression in superficial gastritis or gastric ulcer or erosion, atrophic gastritis or gastric dysplasia and gastric cancer decreased significantly in sequence (P<0.05; 100%/89.2% vs 14.3%/15.2% vs 2.4%). The over-expression rate of PGC in group of superficial gastritis with H pyloriinfection was higher than that in group without H pylori infection (P<0.05; x2= 0.032 28/33 vs 15/25). The positive rate of PGC expression in group of atrophic gastritis with H pylori infection was lower than that in group without H pylori infection (P<0.01; x2 = 0.003 4/61 vs9/30), and in dysplasia and gastric cancer. CONCLUSION: The level of PGC expression has a close relationship with the degree of malignancy of gastric mucosa and development of gastric lesions. There is a relationship between H pylori infection and expression of antigen PGC in gastric mucosa, the positive rate of PGC expression increases in early stage of gastric lesions with H pylori infection such as gastric inflammation and decreases during the late stage such as precancerous diseases and gastric cancer. PGC-negative cases with H py/ori-positive gastric lesions should be given special attention.     

幽门螺杆菌与胃粘膜相关淋巴组织淋巴瘤关系探讨

目的：通过检测胃粘膜相关淋巴组织（MALT）淋巴瘤中的幽门螺杆菌（HP），探讨HP与胃粘膜相关淋巴组织淋巴瘤的关系。方法：收集26例胃MALT淋巴瘤，20例淋巴性胃炎与30例轻度浅表性胃炎的胃粘膜组织病理石蜡切片行0．25％甲苯胺蓝染色，显微镜检查HP，结果：胃MALT淋巴瘤组，淋巴细胞性胃炎组及轻度浅表性胃炎组的HP感染率分别为88．48％，65．00％，43．33％，经统计学分析，差异有显著性（P＜0．05），结论：HP感染与胃MALT淋巴瘤的发生有密切的关系，建议在对胃MALT淋巴瘤行化疗的同时行根除HP治疗。