基于MOOC的教学模式改革在《生物化学与分子生物学》课程中的探索与实践

目的:探讨《生物化学与分子生物学》课程的教学改革模式。方法:以16级生物医学工程专业的3个班学生为研究对象,实验一组采用基于MOOC的翻转课堂教学模式,实验二组采用以课堂讲授为主的基于MOOC的线上线下混合式教学模式,对照组采用传统教学模式。通过对3组学生考核成绩进行比较分析,探究3组教学效果及在培养学生综合素质方面所起的作用。结果:实验二组平均成绩高于实验一组、对照组(P0.05),问卷调查显示多数学生满意实验二组教学法。结论:基于MOOC的线上线下混合式教学模式,可以有效提升教学效果。     

大规模开放在线课程的解读及其与医学教育的思考

大规模开放在线课程存在灵活、开放、免费、优质的特征,其出现为我国的传统高等教育提供了巨大的挑战。MOOC大规模开放在线课程能够为学习者提供创新型的学习模式,有助于实现网络平台上的主动学习,具有重要的应用价值。MOOC 的课程教学过程中,高校应该对教学模式以及教学理念进行重新审视,实现教学结构的根本性变革,不断促进学生教学技能的改善,开发出优质的网络课程。利用MOOC制作医学教育的优质网络课程,借助翻转课程的教学方法,发挥学生的主动性。MOOC 本身具有一定的局限性,并非全部学科课程可以借助网络呈现。本文通过分析大规模在线开放课堂的内涵,深入探究医学教育的有效改善策略,为医学教育的优化提供支持。     

慕课发展下医学教育的思考

医学教育的特殊性和慕课(MOOC)的飞速发展,促使教育工作者认真思考MOOC对我国医学院校教育的影响,本文针对MOOC的发展历程、MOOC的内容和特点,建立医学课程教学MOOC的意义,以及在新的医学模式综合改革形势下,MOOC引入医学教育教学的构想展开探讨,旨在促进MOOC在医学教学改革中的开展和完善。     

Seminar教学法在临床药理学课程中的应用

临床药理学是一门以药理学和临床医学为基础,阐述药物代谢动力学、药物效应动力学、药物毒副反应的性质、药物作用机制及药物相互作用规律的新兴学科。Seminar教学法是由传统的教师讲授为主导的单一模式转向以学生为主体的新的教育模式,能够充分调动学生学习的主动性和积极性,加深学生对课程的掌握以及培养学生的科研能力。我们在临床药理学课程中应用Seminar教学法,促进了临床药理学课程的学习和研究,取得了良好的教学效果。     

大规模网络开放课程背景下图书馆支持医院医教研的新模式

<正>大规模网络开放课程(massive open online course,MOOC)的出现和发展,开启了远程教育的新篇章,并于2012年迎来了爆炸式发展,越来越受到全球学习者的热捧。在MOOC课程教育环境下,如何充分利用开放课程的优势把MOOC理念融入到医院的医疗、教学和科研工作中,促使医护人员充分利用碎片化时间进行自主学习?在信息开放获取     

“网络课程学习+课堂授课+临床用药案例讨论”三维立体的临床药学专业《药物化学》教学模式研究

随着临床精准用药的需求加大,传统的药物化学教学模式越来越难以满足临床药学专业学生的学习需要。本文从《药物化学》课程特点出发,立足于社会实际需要,结合互联网+技术,构建线上线下混合式教学方法,同时匹配临床用药案例分析,形成了三维立体的临床药学专业《药物化学》教学新模式,提高了该课程的教学质量,为医药学院精准药学专业人才的培养提供了新策略。     

从MOOC到SPOC探索高职药物制剂技术教学改革

SPOC是MOOC与传统课堂相结合的产物,是MOOC的继承、完善与超越.SPOC利于MOOC在高校教学落地生根.药物制剂技术是高职药学及相关专业的核心课程,其教学对高职药学及相关专业人才培养起重要作用.本文在剖析MOOC和SPOC特征与关系的基础上,从高职人才培养目标出发,结合药物制剂技术的学科特点,对其课程教学从教学内容、教学模式、教学评价、实践教学、教辅编制等方面进行教学改革论述,为提高课程学与教的质量、更好地培育高素质技能型人才做出积极的探索.     

基于MOOS理念的药学网络学习平台的构建

为充分运用互联网技术培养大学生的创新能力,在对“幕课”MOOC（Masive Open Orlline Comes）网络教学理念的研究基础上,通过对网络学习模式进行更广泛的探索,提出“慕斯”（Mofie Open Onhnesch曲l,即移动在线开放校园,简称MOOS）网络教学新理念,突破单一的课程学习模式,实现网络学习的横向拓展,构建以现代大学生需求为驱动的网络学习生态系统。该文探讨基于MOOS理念构建药学网络学习平台,以期提高药学生的创新思维与能力。     

MOOC教学模式联合虚拟现实技术在康复工程学教学中的应用进展

随着当前科学技术的快速发展,传统的康复工程学教学模式已无法满足康复工程学发展的需要,近年来能够营造逼真学习环境,提供良好操作平台的大规模开放在线课程(massive open online courses, MOOC)教学模式联合虚拟现实技术的逐渐推广应用,切实推动了康复工程学教学的改革,越来越受到人们的广泛关注。本文旨在通过对我国康复工程学的课程教学现状以及基于MOOC的康复工程学课教学模式设计要点与MOOC教学模式联合虚拟现实技术在康复工程学教学中应用现状的概述与分析,为康复工程学教学的改革以及MOOC教学模式联合虚拟现实技术在康复工程学教学中的更好应用提供一定的指导。     

非临床药学专业硕士研究生临床药物治疗学教学效果的调查与分析

目的 :了解非临床药学专业硕士研究生对临床药物治疗学课程学习的效果反馈,为完善教学内容和模式提供依据。方法:对2016—2017学年选修临床药物治疗学的非临床药学专业硕士研究生进行问卷调查,分析课程内容安排、药师讲课方式、学生参与度等目前存在的问题。结果:83.33%的学生认为授课内容已包含他们所想要了解的领域,而90.00%的学生认为不同课程的课时分配欠妥。86.67%的学生认为药师在讲授"临床药物治疗学"课程中突出了药学特色,而66.67%的学生认为其课堂参与度较低。结论:非临床药学专业硕士研究生临床药物治疗学的教学内容和教学模式还需进一步探索和完善。     

“医”与“法”

2003年8月中,惠氏百宫制药有限公司邀请广东地区各大医院的专家和医院管理人员在广东东莞举行了一场别开生面的研讨会。会议包括两个议题:一是“特治星治疗严重呼吸道感染”的学术研讨;二是“医疗纠纷处理的新规则与新思路”的研讨。会上“热点”不断,台上、台下观点撞击精彩纷呈,这里我们摘录片段与大家共享。     

Laboratory Verification of "heavy" and "light" users of cannabis

For various experimental studies it is often desirable to classify categories of cannabis use. For instance, in a study of the kinetics of δ-9-tetrahydrocannabinol (THC) in man, we wanted to see if there were differences between “heavy” and “light” users of the drug. “Heavy” use was defined as once daily or more, while “light” use was defined as sporadic or occasional, no more frequent than once monthly.Previously, we had found that the 11-oic acid of THC was not only the major metabolite to appear in the urine but also that its appearance in urine was prompt and lasted for at least 72 hours after a single exposure [1]. We decided to use the presence of this material in urine as a marker for heavy and light use; one would expect to find it regularly in heavy users and rarely, if at all, among light users. All subjects entering the study declared their pattern of use and then were asked to provide a spontaneously voided urine, to be used for analysis of THC-11-oic acid.     

以"豆"祛"痘"

虽然早已过了青春期,但我那略显"婴儿肥"的脸上还是会不时地出现些小痘痘.为了消除这些可恶的家伙,我还真是没少折腾,又是吃药、吃保健品,又是用化妆品,可痘痘却大有"野火烧不尽,春风吹又生"之势,看来要消灭它们可不是件容易的事.     

Activity of "reversed" diamidines against Trypanosoma cruzi "in vitro"

Chagas' disease is an important parasitic illness caused by the flagellated protozoan Trypanosoma cruzi. The disease affects nearly 17 million individuals in endemic areas of Latin America and the current chemotherapy is quite unsatisfactory based on nitroheterocyclic agents (nifurtimox and benznidazol). The need for new compounds with different modes of action is clear. Due to the broad-spectrum antimicrobial activity of the aromatic dicationic compounds, this study focused on the activity of four such diamidines (DB811, DB889, DB786, DB702) and a closely related diguanidine (DB711) against bloodstream trypomastigotes as well as intracellular amastigotes of T. cruzi in vitro. Additional studies were also conducted to access the toxicity of the compounds against mammalian cells in vitro. Our data show that the four diamidines compounds presented early and high anti-parasitic activity (IC50 in low-micromolecular range) exhibiting trypanocidal dose-dependent effects against both trypomastigote and amastigote forms of T. cruzi 2h after drug treatment. Most of the diamidines compounds (except the DB702) exerted high anti-parasitic activity and low toxicity to the mammalian cells. Our results show the activity of reversed diamidines against T. cruzi and suggested that the compounds merit in vivo studies.     

"Central" and "peripheral" benzodiazepines and kinetics of lindane-induced toxicity

Because hypothermia and anorexia were previously found to be more sensitive indices of the effects of lindane than were convulsions, these endpoints were used to quantify the ability of benzodiazepines (BDs) and phenytoin either to ameliorate or exacerbate the toxicity of lindane in the rat. After administration of lindane (40 or 50 mg/kg) in oil per os, toxicity was counteracted by phenytoin and the "central" BD agonists diazepam and clonazepam, but was worsened by Ro 5-4864 a "peripheral" BD agonist. Clonazepam and diazepam were each more effective in counteracting lindane-induced anorexia than in stimulating food intake, presumably because the animals had been fasted and probably even controls ate maximally when food was presented. Diazepam alone (3 injections in 1 day) produced withdrawal-induced decreased food intake the following day. Clonazepam and diazepam alone each transiently decreased colonic temperature, yet effectively blocked the more severe hypothermia produced by lindane. Ro 5-4864 by itself did not produce any measurable effects, yet exacerbated all of the effects, including lethal effects, of lindane. The present findings are compatible with other evidence that lindane and Ro 5-4864 act at the picrotoxinin receptor of the GABAA-activated chloride channel and that systemic administration of agents acting at this site may produce a constellation of effects, including seizures, hypothermia and anorexia.