吡拉西坦联合尼莫地平治疗脑梗死后血管性痴呆临床分析

目的探讨吡拉西坦与尼莫地平联合治疗脑梗死后血管性痴呆患者的临床效果。方法选取2014年7月至2016年8月开封美宝空分医院收治的82例脑梗死后血管性痴呆患者,按照随机数表法分为两组,各41例。对照组患者接受尼莫地平治疗,观察组患者接受吡拉西坦联合尼莫地平治疗,两组患者均治疗3个月。比较两组患者治疗前后简易智力状态检查量表(MMSE)、日常生活能力(ADL)评分,治疗效果及不良反应发生情况。结果治疗前两组患者MMSE、ADL评分比较,差异无统计学意义(P>0.05);治疗后观察组患者MMSE高于对照组,ADL评分低于对照组,治疗总有效率高于对照组,差异均有统计学意义(P<0.05)。结论尼莫地平联合吡拉西坦能提高脑梗死后血管性痴呆患者智力水平和日常生活能力,效果显著且安全性高。     

CT影像学对血管性痴呆患者的诊断价值

目的：探讨CT影像学对于血管性痴呆患者的临床诊断价值。方法：选择2009年3月—2011年4月在我院治疗的86例血管性痴呆（VD）患者作为VD组,同时选择85例非痴呆卒中患者作为对照组,所有患者均进行CT检查及认知功能评价,对两组患者认知功能及CT表现进行比较。结果：VD组患者的MMSE评分为22．4±1．6,对照组患者的MMSE评分为26．8±1．9,VD组患者的MMSE评分明显低于对照组（P〈0．05）;头部CT结果显示患者脑组织出现低密度的梗死病灶或高密度的出血病灶。两组患者病灶部位、病灶大小及脑萎缩发生率具有显著性差异（P〈0．05）。结论：CT检查对血管性痴呆患者具有很好的临床诊断价值,可清晰反映患者的病情变化。     

康复护理干预对老年血管性痴呆患者认知功能及日常生活能力的影响

目的观察分析康复护理干预对老年血管性痴呆患者认知功能及日常生活能力的影响。方法选取2015年5月至2017年1月鄢陵县中医院收治的老年血管性痴呆患者90例,根据就诊顺序分为对照组和观察组,各45例。对照组接受常规护理,观察组在常规护理基础上接受康复护理干预。观察两组患者的认知功能(MMSE评分)及日常生活能力(ADL评分)。结果护理前,两组患者MMSE评分和ADL评分比较,差异均无统计学意义(P>0.05);护理后,观察组MMSE评分和ADL评分均高于对照组,差异有统计学意义(P均<0.05)。结论康复护理干预应用于老年血管性痴呆患者效果显著,可改善患者认知功能,提高其日常生活能力,值得临床推广应用。     

盐酸多奈哌齐治疗血管性痴呆的临床疗效观察

目的:观察盐酸多奈哌齐治疗血管性痴呆患者的疗效。方法:选择血管性痴呆患者78例,随机分为观察组和对照组。观察两组患者治疗前后MMSE评分、HDS评分及ADL积分进行比较分析,并对盐酸多奈哌齐的安全性进行评价。结果:与治疗前相比,盐酸多奈哌齐治疗组治疗后的MMSE评分和HDS评分明显提高,ADL积分明显降低,差异有统计学意义(P<0.05),而对照组治疗前后的MMSE评分、HDS评分和ADL积分差异均无统计学意义(P>0.05)。与此同时,两组患者治疗前后一般体格体检、神经系统检查、血、尿及大便常规,肝、肾功能均无明显异常。结论:盐酸多奈哌齐能够有效地改善血管性痴呆患者的认知功能障碍,降低痴呆程度及提高生活自理能力等显著疗效。     

多奈哌齐联合瑞舒伐他汀治疗皮质下缺血性血管性痴呆临床研究

目的观察并探讨多奈哌齐联合瑞舒伐他汀治疗皮质下缺血性血管性痴呆临床应用价值。方法选取我院2016年1月到2016年6月神经内科收治的60例皮质下缺血性血管性痴呆患者,按入院顺序分为研究组与对照组,各30例。对照组采用多奈哌齐治疗,研究组采用多奈哌齐联合瑞舒伐他汀治疗,对比两组患者的治疗效果。结果经治疗后,两组患者的MMSE和ADL评分均有所改善,研究组取得的治疗总有效率明显高于对照组,研究组的MMSE和ADL评分明显优于对照组两组对比差异明显,有统计学意义(P0.05)。结论对皮质下缺血性血管性痴呆病采用多奈哌齐联合瑞舒伐他汀治疗,疗效显著,患者精神状态与生活能力均有所改善,值得临床推广应用。     

高压氧联合吡拉西坦片及丁苯酞软胶囊治疗老年血管性痴呆患者的效果

目的研究高压氧联合吡拉西坦片及丁苯酞软胶囊治疗老年血管性痴呆患者的效果。方法选取洛阳市第六人民医院2016年3月至2018年10月收治的78例老年血管性痴呆患者,按照随机抽签法分为两组,各39例。对照组接受吡拉西坦片及丁苯酞软胶囊治疗,观察组在对照组基础上接受高压氧治疗。比较两组治疗效果、治疗前后认知功能(MMSE评分)和日常生活能力(ADL评分)。结果观察组总有效率(89.74%)较对照组(71.79%)高(P<0.05);治疗后,观察组MMSE和ADL评分较对照组高(P<0.05)。结论高压氧联合吡拉西坦片及丁苯酞软胶囊治疗老年血管性痴呆患者,效果显著,可改善认知功能,提高日常生活能力。     

奥拉西坦联合尼莫地平治疗血管性痴呆的疗效观察

目的 探究奥拉西坦联合尼莫地平治疗血管性痴呆的疗效.方法 选取2017年5月至2020年5月本院收治的78例血管性痴呆患者,根据治疗方法的不同分为对照组和观察组,每组39例.对照组采用尼莫地平单一治疗,观察组采用奥拉西坦联合尼莫地平治疗.比较两组患者血管性痴呆恢复和不良反应发生情况.结果 治疗后,观察组患者简易智力状态检查(MMSE)、日常生活能力量表(ADL)、长谷川痴呆量表(HDS)评分均高于对照组,差异均有统计学意义(P<0.05);两组患者不良反应发生率比较差异无统计学意义.结论 奥拉西坦联合尼莫地平治疗血管性痴呆效果显著,安全性高,有利于提高患者认知功能和日常生活能力,值得临床推广应用.     

艾地苯醌联合丁苯酞胶囊对青年血管性痴呆患者的疗效

目的探讨艾地苯醌联合丁苯酞胶囊对青年血管性痴呆患者的临床效果和安全性。方法选取2012年7月至2018年5月在郑州人民医院神经内科住院的血管性痴呆患者86例,按随机数表法分为对照组与观察组,各43例。给予对照组阿司匹林肠溶片和阿托伐他汀钙片应用,在对照组基础上给予观察组艾地苯醌联合丁苯酞胶囊,比较两组治疗前后简易智能量表(MMSE)评分及日常生活能力量表(ADL)评分,观察药物不良反应。结果治疗前,两组MMSE及ADL评分比较,差异无统计学意义(P>0.05)。治疗3个月后,两组MMSE评分高于治疗前,ADL评分低于治疗前,差异有统计学意义(P<0.05);观察组MMSE评分高于对照组,ADL评分低于对照组,差异有统计学意义(P<0.05)。两组在治疗期间均未出现严重不良反应。结论艾地苯醌联合丁苯酞软胶囊治疗效果优于单用丁苯酞胶囊,能提高青年血管性痴呆患者的认知功能及其日常生活能力,安全性好。     

多奈哌齐联合奥氮平治疗血管性痴呆的精神行为异常的观察

目的观察分析精神行为异常症状血管性痴呆应用英多奈哌齐联合奥氮平治疗的效果。方法选取2015年、2016年我院收治的精神行为异常症状血管性痴呆的患者81例为本次研究对象,按照治疗方式的不同分成两组,观察组、对照组,两组患者均应用多奈哌齐联合奥氮平治疗,对照组患者使用剂量为5mg,观察组患者使用剂量为10mg。比较两组患者治疗前后不同时间段激越行为(CMAI)评分、简易智能精神状态检查量表(MMSE)评分、日常生活活动能力(ADL)评分。结果两组患者接受治疗3个月后,观察组患者的CMAI评分、MMSE评分、ADL评分明显高于对照组,差异显著,P0.05,具有统计学意义。结论精神行为异常症状血管性痴呆应用英多奈哌齐联合奥氮平治疗具有积极的效果,使用大剂量治疗效果更加,患者无明显不良反应发生,值得临床推广。     

银杏联合尼麦角林片对血管性痴呆患者认知功能的改善

目的:探讨银杏片联合尼麦角林治疗认知功能障碍的血管性痴呆患者的临床疗效。方法:将老年期血管痴呆患者86例按随机摸球法均分成联合用药组和对照组,每组各43例。所有患者均进行血压、血脂、血糖等常规治疗及控制;联合用药组患者给予加用银杏叶片与尼麦角林片,对照组患者仅加用尼麦角林片。以日常生活能力量表(ADL)和简易精神状态检查(MMSE)为评价指标,评估两组患者用药前及用药后6个月认知障碍和痴呆程度。结果:两组患者用药后6个月ADL评分和MMSE评分均较用药前有所改善,差异显著(P<0.01)。对联合用药组患者的ADL评分从(53.33±6.79)下降至(42.34±5.22),MMSE评分从(17.34±4.28)升高至(24.61±5.57),差异明显(P<0.05);对照组患者的ADL评分从(53.27±7.14)下降至(47.28±5.31),MMSE评分从(17.27±4.36)升高至(21.79±5.45),差异明显(P<0.05)。结论:银杏片联合尼麦角林片对血管性痴呆患者的认知功能障碍有改善作用,效果好于单用尼麦角林。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.