连续捐献单采血小板献血者血红蛋白和铁蛋白状况调查及分析

目的 调查连续捐献单采血小板对献血者血红蛋白和铁蛋白的影响.方法 选择2018年3-6月北京市红十字血液中心男性献血者73名(平均献血周期为15.26d),依据5次献血的铁蛋白水平分为第1组(n=21,≥30 μg/L)、第2组(n=23,＜30pug/L)和第3组(n=29,在30 μg/L上下变化),对其连续捐献5...     

献血间隔时间对血小板采集质量的影响

目的分析献血间隔时间对血小板采集质量的影响。方法选取佛山市顺德区中心血站单采血小板献血者3 280例,其中Trima血小板分离机采集血小板2 778例,MCS+采集512例。献血者每次献血之前做血常规检查(献血间隔时间为14 d),隔14 d后捐献抽标本检查血常规,观察并记录3 280例献血者血小板献血后血常规指标变化情况(红细胞、白细胞、血红蛋白、血小板)。结果每隔14 d后,机体血小板计数与献血之前比较,差异有统计学意义(P0.05)。献血30 d后,机体血小板计数与献血前基本一致(P0.05)。结论以血小板计数分析献血者的献血周期,献血周期保持在合适的间隔周期并不会影响献血者的身体健康。     

2009-2018年单采血小板捐献者保留的策略分析

目的通过分析上海某血站单采血小板无偿献血情况,探讨保留单采血小板捐献者的策略,为进一步加强单采血小板献血志愿者的保留工作提供依据。方法采取问卷调查和电话回访等方法,回顾性总结2009-2018年上海某血站的血小板单采工作状况,比较无偿献血者的性别、动机、采血者服务等对献血者献血意愿和再次献血行为影响的相关性,分析对固定献血者保留的相关影响因素。结果固定献血人群中女性比例较高,医护人员良好的服务是促进固定献血者保留的重要因素,献血者时间和地点的改变是影响成分献血的主要因素,提高献血者对自我价值的实现是有效的再招募手段。结论通过献血宣传、精准服务以及后期交流等方式可以提高对血小板固定献血者的保留。     

单采血小板献血者铁储备状况的分析

目的:了解单采血小板献血者体内铁储备状况,为研究和制定更细致和更完善的单采血小板献血者健康检查标准提供有力的实验依据。方法:采用横断面调查,选取2018年10月符合标准的297例单采血小板献血者样本,分析影响铁储备指标的相关性因子,从年度单采血小板次数方面,探讨其对献血者体内血红蛋白(Hb)、血清铁蛋白(SF)及铁缺乏率的影响,全面调查献血者的铁储备状况。结果:单采血小板献血者SF水平与年度单采血小板次数呈负相关(r=-0. 416,P 0. 01);随着年度献血次数的增加,SF水平不断下降,差异具有统计学意义(P 0. 05);随着年度献血次数增加,单采血小板献血者铁缺乏比率有增加的趋势。男性18-23次组铁缺乏比率为12. 5%(8/64),女性18-23次组的铁缺乏比率为40%(6/15)。结论:采供血机构对重复单采血小板献血者可适当减少招募次数,有必要增加SF的检测。     

单采血小板捐献者血清铁蛋白与部分血常规指标的相关性分析

目的 分析单采血小板捐献者血清铁蛋白(serum ferritin,SF)与部分血常规指标的相关性,为筛选对SF含量有预示作用的血常规指标提供参考.方法 以2010年10月至2011年2月在本血站献血的111例单采血小板捐献者为研究对象,采用酶联免疫吸附法(enzyme-linked immunosorbent ass...     

固定无偿单采血小板献血者血液学指标变化初探

目的 探讨血小板单采对于不同性别、年龄固定无偿单采血小板献血者血液学指标的影响。方法 根据累计献血次数的不同分为5组，分别测定每位献血者第一次血小板单采和最后一次血小板单采时的血小板、血红蛋白、白细胞数，进行统计分析。结果 血小板单采对于不同性别、年龄固定无偿单采血小板献血者血液学指标（血小板、血红蛋白、白细胞）的影响略有差异。结论 只要严格执行国家规定的单采血小板献血条件，固定血小板单采不会影响献血者健康。     

不同间隔期、献血量对献血者血清铁和铁蛋白影响效果观察

目的探索不同间隔期、不同献血量定期献血对献血者血清铁蛋白和铁的影响效果。方法选自2015年3月-2018年3月于本中心的325例定期献血者作为研讨组,同时段内选取100例从未献血的正常体检人员作为参照组,分别测定血清铁蛋白与铁的水平,并进行观察对比。结果与参照组(无献血史)对比,不同的献血量的研讨400 mL组、300 mL组、200 mL组的血清铁水平相近,P>0.05;血清铁蛋白则差异显著(F=6.327,P<0.05);而且3个不同献血量研讨组之间,400 mL组与200 mL组差异明显(t=8.272,P<0.05)。不同间隔期献血者研究中,献3次(平均间隔期为12个月)、4次(平均间隔期为9个月)的献血者跟参照组(无献血史)比较,血清铁蛋白和血清铁结果无差异;献5次(平均间隔期为7.2个月)、6次(平均间隔期为6个月)跟参照组比较,血清铁差异不显著(P>0.05),但血清铁蛋白差异显著(5次vs.参照组:t=5.378,P<0.05;6次vs.参照组:t=6.894,P<0.05)。结论通过对不同献血量不同间隔期定期献血者与无献血史的正常体检人员的血清铁蛋白与铁的水平进行观察对比,献血200-400 mL,6个月<间隔期<9个月者血清铁蛋白减少,有利于身体健康。     

单采血小板献血者发生献血反应的原因分析及处理措施

目的通过分析单采血小板献血者发生献血反应的原因,以便采取相应措施减少献血反应的发生,保证单采血小板献血者的安全与健康。方法统计2009年1月至2011年12月本站单采血小板献血者的总人数和各型献血反应人次,并就出现献血反应的诱因进行统计分析。结果 6 206例单采血小板献血者中,发生献血反应133例,总反应率2.14%,其中轻度献血反应108例（1.74%）、中度献血反应19例（0.31%）、重度献血反应6例（0.10%）,各类比率均逐年下降,但仍以轻度献血反应为主,枸橼酸盐中毒、心理、精神因素为献血反应的最主要诱因。结论献血反应与枸橼酸盐中毒、心理、精神因素密切相关。因为献血反应的产生与多种因素相关,医务人员应具备识别特征表现应对处理的能力,同时血站应该加强献血知识宣教,从而避免献血反应的发生。     

2018-2022年南昌地区单采血小板捐献情况分析

目的 分析2018-2022年南昌地区单采血小板献血者年龄、性别、职业、献血量变化等特征,为发展本地区单采血小板固定献血队伍提供依据,保障临床供血安全。 方法 收集2018-2022年江西省血液中心血站信息管理系统中单采血小板捐献信息,分年度统计献血人次、年龄、性别、职业、献血量、户籍、献血次数、二次献血占比,并进行比较。 结果 2018-2022年,南昌地区单采血小板捐献人次呈前增后降变化态势,2021年最多,达9662人次;年龄分布上,35岁及以上年龄段单采血小板献血者人次占比达到61.78%后逐步下降,最低至48.70%。18-24岁年龄段单采血小板献血者人次占比由18.35%开始逐步增高,最高至32.71%;男性是主要的单采血小板献血人群,占年度总献血人次77.61%～78.40%;登记职业为其他的人群是主要单采献血人群,占年度总献血人次43.71%-51.56%;单次捐献2U血小板人次比例持续增长,最高达82.03%;年度内献血1次人数占比较高,最高至66.42%;首次单采血小板献血者年度内二次献血比例较低,最高仅为21.48%。 结论 2018-2022年间,南昌地区单采血小板献血事业取得了一定发展,但基础不够牢固,应对风险能力不足。在后疫情时代,应针对本地区单采血小板献血者以年轻人、男性、其它类职业为主的特点,制定定向招募政策;应开发不定期单采血小板献血者、首次单采血小板献血者二次招募动员专项策略,提升二次献血率;应积极贯彻落实全流程优质服务理念,增强献血者粘性;应组建好应急单采献血队伍并定期更新,并确保应急单采献血队伍能联系、能响应以加强应急保障潜力。通过一系列举措,有效组建并扩大本地区单采血小板固定献血者队伍,夯实单采血小板献血事业发展基础,保障地区单采血小板临床供血安全。     

单采血小板献血者献血反应原因分析

目的探讨影响单采血小板献血者发生献血反应的原因,以便采取相应措施减少或预防献血反应的发生,保证献血者的健康。方法对2008-2012年本站736名单采血小板献血者的资料进行回顾性调查分析。结果736名单采血小板者中,发生献血反应的108例。总反应率14.7%,其中轻度37例(34.3%),中度8例(7.4%),重度1例(0.93%),枸橼酸盐中毒占62例(57.4%)。结论献血者性别、体重、处理抗凝全血量、献血次数、空腹献血等因素是单采血小板献血者发生献血反应的主要原因,且各种因素相互作用、相互促进,是一个综合影响因素。因此,我们要从源头开始,要注重每一个环节,从最大程度上减少或预防单采献血反应的发生。     

Study of iron stores in regular plateletpheresis donors

summary . Plateletpheresis donors will lose up to 100 mL of blood at each donation, leading to concern that they may become iron deficient, particularly if donating at the maximum allowed frequency under National Blood Service policy of every 2 weeks. The serum ferritin levels of 508 regular plateletpheresis donors and 101 non-donors were measured to indicate the level of their iron stores. About 33·9% (156/460) of platelet donors had depleted iron stores compared with 3·1% (3/97) non-donors. Results for male and post-menopausal female donors were similar with 36·2% (131/362) of males and 37·7% (20/53) of post-menopausal females showing iron depletion. There was clear correlation with donation frequency in males with 63·9% (46/72) of males donating at 2 weekly intervals found to be iron depleted. The percentage of iron depleted male subjects decreased as donation intervals increased. Correlation with lifetime donations of platelets was not demonstrated, although no donor who had given fewer than 14 blood and/or platelet donations was found to be iron depleted. In males there was a clear correlation between iron depletion and frequency of donation. There appeared to be no correlation with lifetime number of platelet donations. As a result of this study, we have advised that volunteers should not donate platelets more than 15 times per year, so that red cell loss is no more than the equivalent of three whole blood donations (1500 mL).     

Assessment of serum iron stores in regular plateletpheresis donors

BackgroundIron deficiency anaemia is the most common nutritional deficiency disorder in the world. Iron deficiency is a potential complication in repeated apheresis donation. The present study was aimed to evaluate serum iron stores in regular plateletpheresis donors.Materials and methodsA total of 60 donors were included in this study, which included 30 regular plateletpheresis donors as cases and controls were 30 first time donors. The donor samples were collected before donation for complete hemogram, transfusion transmissible infections screening and serum iron, total iron binding capacity, percentage saturation of transferrin and serum ferritin.ResultsOut of 60 donors, more than half of the donors (56.6 %) had serum ferritin less than 30 ng/mL. Out of these 34 donors, 25 were from the case group and 9 donors in the control group. The median serum ferritin level in cases and controls was 11.86 ng/mL (Interquartile range 4.18–17.34 ng/mL) and 37.92 ng/mL (Interquartile range 27.87–86.20 ng/mL) respectively (p < 0.001). The mean serum iron in cases and controls was 71.23 ± 31.32 μg/dL and 93.53 ± 33.53 μg/dL respectively (p = 0.016). The mean percentage saturation in cases and controls was 20.09 ± 9.31 % and 26.26 ± 9.03 % respectively (p = 0.012). A significant decline in mean serum ferritin with increase in number of annual donations and decrease in donation interval was observed.DiscussionRegular plateletpheresis donation may lead to depletion of iron stores and subclinical iron deficiency. Donors with high platelet count are more likely to exhibit iron deficiency. Periodic serum ferritin estimation in donors participating in regular plateletpheresis donation is warranted.     

北京地区全血献血者铁蛋白调查分析

目的 对北京地区全血献血者铁蛋白检测,分析与铁蛋白低值异常相关的影响因素,为全血献血者科学补铁提供依据.方法 以2018年3-6月北京地区27 071名全血献血者为研究对象,进行铁蛋白检测.使用Logis-tics 回归分析影响铁蛋白低值异常的献血者相关信息,确定最容易出现铁蛋白低值异常的全血献血者类型.结果 北京地区...     

定期多次单采血小板捐献者血清铁蛋白状况分析

本研究分析定期多次捐献单采血小板对血清铁的影响.随机抽取本站男性首次单采血小板捐献者24例和定期多次单采血小板捐献者69例,用ELISA法检测其血清铁蛋白(SF)含量.结果表明,首次单采血小板捐献者和定期多次单采血小板捐献者的SF含量分别为91.08±23.38μg/L和57.16±35.48μg/L,但均在正常值范围内,两者之间的差异具有统计学意义(p<0.05).SF含量随血小板捐献频率的增加而下降,但各捐献频率组之间的差异均不具有统计学意义(p>0.05).随血小板捐献次数的增加,SF含量呈现波动性的变化.结论:定期多次捐献单采血小板可导致SF减少.     

Low ferritin levels indicate the need for iron supplementation: strategy to minimize iron-depletion in regular blood donors

Iron deficiency is a common problem in regular blood donors which can be prevented by timely iron supplementation. Consequently, these donors should be supplied with oral iron in good time. We evaluated the need to use ferritin rather than or in addition to haemoglobin to screen iron deficiency in blood donors. To this end, serum ferritin was measured routinely every 10th donation in 632 long-term and 171 first-time donors. Furthermore, donors with ferritin < 15 microg L-1 were supplemented with iron. The supplementation efficiency was assessed by follow-up haemoglobin levels over the course of five donations in blood donors with high donation frequency. Our results showed that ferritin decreases after 10 donations and with the increase of donation frequency. In 26% of regular donors, ferritin levels were < 15 microg L-1 and 12% of them were anaemic due to low haemoglobin. After iron supplementation, haemoglobin was raised rapidly in donors with initially low haemoglobin, and thus donor deferment was never indicated. In conclusion, regular ferritin measurement is a useful indicator for iron depletion in blood donors. Our data suggested the usefulness of ferritin screening in first-time donors and regular donors with low haemoglobin levels within the normal range.     

Comparison of demographics and motivations of highly committed whole blood and platelet donors

To compare donor demographics and motivations for donation, we surveyed 159 consecutive whole blood donors (WD) and 146 consecutive plateletpheresis donors. All donors had donation experiences of at least 2 gallons (i.e., 16 previous donations). Evaluation of answers to fixed-response and open-ended questions revealed no difference between the two groups in age, type of wages, compensation by employer, “time off” for donation, and church or volunteer organization memberships. The two groups differed in that the platelet donor (PD) group had a higher percentage of males than females (PD group 72.6% males and 27.4% females versus WD group 59% males and 41% females [chi-square = .01]). PDs most often began donating platelets because they were asked (22.6%), demonstrating the importance of active recruitment. When asked why they do not donate platelet products by apheresis, highly committed WDs reported lack of time (25%), lack of knowledge (“Don't know about it,” 21%), lack of recruitment (“No one asked,” 18.5%), or lack of awareness (“Never thought about it,” 5%) as reasons. Factors centering on time constraints, lack of knowledge or awareness about platelet donation by apheresis, and lack of active recruitment prohibit highly committed WDs from entering into plateletpheresis programs. © 1993 Wiley-Liss, Inc.     

Poor iron store recovery in voluntary blood donors in the northern zone of Ghana; a five-month three-centre cohort study

ObjectiveIn Ghana, although iron deficiency is endemic, post blood donation iron supplementation is not routine. We sought to determine whether at five months post-donation of a single unit of whole blood, donors were able to recover iron stores.Materials and methodsThis three-centre cohort study recruited 164 blood donors at the Lawra, Nandom, and Bimbila communities in the northern zone of Ghana. Venous blood samples were drawn at baseline to estimate full blood count (FBC), haemoglobin variants, qualitative G6PD status, and serum ferritin. Five months post-donation, venous blood samples were drawn for a repeat measurement of FBC and serum ferritin. Data were analysed using SPSS and GraphPad prism to assess recovery of iron stores.ResultsWhereas 26.8 % had inherited haemoglobin variants, 18.9 % of the donors had qualitative G6PD deficiency. Overall, mean difference between pre-donation and five months post donation iron stores significantly differed from zero (p < 0.001; one sample t-test). After five months post donation, 76.8 % of the blood donors could not achieve pre-donation iron stores. Whereas 6.1 % and 8.5 % blood donors had depleted iron stores and iron deficient erythropoiesis at baseline, these increased to 9.8 % and 21.3 % respectively at five-month post donation. Moreover, at five months post donation, 11 % of these blood donors would have been disqualified per haemoglobin screening cut off of 12.5 g/dl.ConclusionReliance on food intake to replenish iron store lost per blood donation may not adequately assure donor health in the study area; iron supplementation should be considered.     

Iron deficiency in blood donors: analysis of enrollment data from the REDS‐II Donor Iron Status Evaluation (RISE) study

BACKGROUND: Regular blood donors are at risk of iron deficiency, but characteristics that predispose to this condition are poorly defined. STUDY DESIGN AND METHODS: A total of 2425 red blood cell donors, either first‐time (FT) or reactivated donors (no donations for 2 years) or frequent donors, were recruited for follow‐up. At enrollment, ferritin, soluble transferrin receptor (sTfR), and hemoglobin were determined. Donor variables included demographics, smoking, dietary intake, use of iron supplements, and menstrual and/or pregnancy history. Models to predict two measures of iron deficiency were developed: Absent iron stores (AIS) were indicated by a ferritin level of less than 12 ng/mL and iron‐deficient erythropoiesis (IDE) by a log(sTfR/ferritin) value of 2.07 or greater. RESULTS: A total of 15.0% of donors had AIS and 41.7% IDE. In frequent donors, 16.4 and 48.7% of males had AIS and IDE, respectively, with corresponding proportions of 27.1 and 66.1% for females. Donation intensity was most closely associated with AIS and/or IDE (odds ratios from 5.3 to 52.2 for different donation intensity compared to FT donors). Being female, younger, and/or menstruating also increased the likelihood of having AIS and/or IDE, as did having a lower weight. Marginally significant variables for AIS and/or IDE were being a nonsmoker, previous pregnancy, and not taking iron supplements. Dietary variables were in general unrelated to AIS and/or IDE, as was race and/or ethnicity. CONCLUSION: A large proportion of both female and male frequent blood donors have iron depletion. Donation intensity, sex and/or menstrual status, weight, and age are important independent predictors of AIS and/or IDE. Reducing the frequency of blood donation is likely to reduce the prevalence of iron deficiency among blood donors, as might implementing routine iron supplementation.