鼻咽癌病人放疗前后多种诱发电位的比较研究

目的：了解鼻咽癌（NPC）病人放疗，放疗后射线是否会引起多种诱发电位的改变。方法：对48例初次放疗的NPC病人在放疗前与放疗后各阶段进行脑干听觉诱发电位（BAEP），短潜伏期体感诱发电位（SLSEP），图形翻转视觉诱发电位（PRVEP）追踪研究。结果：与放疗前对比，本组病人放疗后不同的阶段BAEP、SLSEP、PRVEP某些波的伏期与波间潜伏期均值和放疗前的检测结果比较差异有显著性。结论：NPC病人接受放射治疗后，早期即可引起神经系统传导功能障碍，诱发电位技术可以反映这种传导功能障碍的存在，而BAEP、SLSEP、PRVEP3种诱发电位协同应用，可及时发现射线对听感觉、体感觉、视觉传导通路损伤。

Study on change of multimodally evoked potentials in nasopharyngeal carcinoma patients after radiotherapy

Objective\ To investigate possible changes of multimodally evoked potentials in nasopharyngeal carcinoma patients after radiotherapy. Methods\ Altogether 48 nasopharyngeal carcinoma patiens receiving primary conventional external beam irradiation were examined before and after radiotherapy to determine their brainstem auditory\|evoked potential(BAEP),short\|latency somatosensory\|evoked potential(SLSEP)and pattern reversal visual\|evoked potential(PRVEP). Results\ In comparion with the conditions before radiotherapy,in different periods after radiotherapy abnormal peak latency and interval latency difference were found in BAEP,SLSEP and PRVEP. Conclusion\ Nasopharyngeal carcinoma after radiotheray may cause abnormal function of nerve conduction in early periods,which can be showed by BAEP,SLSEP,PRVEP,and injury can be timely detected if the three evoked potentials are used together.Thus we suggest BAEP,SLSEP,PRVEP should be examined in nasopharyngeal carcinoma patients during and after the radiotherapy so as to find early damage in auditory somatosensory and visual conduction pathways.