Negative inotropic effect of selective AT2 receptor stimulation and its modulation by the endocardial endothelium |
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Authors: | Castro-Chaves Paulo Soares Susana Fontes-Carvalho Ricardo Leite-Moreira Adelino F |
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Affiliation: | aDepartment of Clinical Pharmacology, Faculty of Medical Sciences, University Medical Center Groningen, The Netherlands bDepartment of Pathology and Laboratory Medicine, University Medical Center Groningen, The Netherlands |
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Abstract: | Kidney transplantation represents the therapy of choice for many patients with end-stage renal disease. However, the success of renal engraftment is hindered by a number of factors, the most important of which being adverse effects of systemic immunosuppressive therapy, chronic transplant dysfunction and a severe shortage of donor kidneys. Gene therapy approaches may provide valuable strategies in each of these areas. First, gene therapy holds the potential of local therapy, thus circumventing systemic side effects of chronic immunosuppression. Second, chronic transplant dysfunction may be addressed by innovative strategies to induce local immune tolerance, immune suppression and additional graft protecting mechanisms. Third, gene therapy may be instrumental in increasing the quality of the grafts by limiting ischemia-reperfusion injury, especially in non-heart beating donors, thereby expanding the donor pool. In this article, we give an overview of the current state of gene therapy in experimental models of kidney transplantation. |
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Keywords: | Acute rejection Chronic transplant dysfunction Gene therapy Gene transfer Ischemia-reperfusion injury Kidney Transplantation Tolerance |
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