| Tregs对同种异体牙移植免疫排斥反应的抑制作用 |
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| 引用本文： | 金光春,陈从容,李言君,薛江南,姜玲,李升钟,金东春.Tregs对同种异体牙移植免疫排斥反应的抑制作用[J].中国医药科学,2011(12):39-41. |
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| 作者姓名： | 金光春 陈从容 李言君 薛江南 姜玲 李升钟 金东春 |
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| 作者单位： | 滨州医学院;韩国延世大学;延边大学 |
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| 基金项目： | 山东省卫生厅科技发展计划(编号:2007HZ042);山东省教育厅科技研究计划(编号:J06L93);科研启动基金(编号:BY2005KYQD16);学术骨干学科带头人培养项目(编号:BY2005XSGG009) |
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| 摘 要： | 目的探讨Tregs对同种异体牙移植术后免疫排斥反应的抑制作用,提供一种免疫移植方法。方法免疫抑制剂Tregs给予白鼠尾巴静脉注射1周,建立白鼠同种异体牙移植模型,术后观察移植牙存活、排异发生率及程度。结果同种异体牙均诱发免疫排斥反应,但Tregs注射后免疫排斥反应的时间缓慢,组织切片存活时间显著延长(P<0.01)。结论使用免疫抑制剂是预防同种异体牙移植免疫排斥反应的有效方案,可以使同种异体牙移植免疫排斥反应延迟,存活时间延长。
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| 关 键 词： | 同种异体牙移植 免疫排斥 免疫抑制剂 磷酸盐缓冲液 |
Suppression Effects of Tregs on Immunological Rejection in Tooth Allotransplantation |
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| JIN Guangchun,CHEN Congrong,LI Yanjun,XUE Jiangnan,JIANG Ling,LEE Seongjong,JIN Dongchun.Suppression Effects of Tregs on Immunological Rejection in Tooth Allotransplantation[J].China Medicine and Pharmacy,2011(12):39-41. |
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| Authors: | JIN Guangchun CHEN Congrong LI Yanjun XUE Jiangnan JIANG Ling LEE Seongjong JIN Dongchun |
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| Affiliation: | 1.Binzhou Medical University,Yantai 264003,China;2.Yonsei University,Seoul 120-752;3.Yanbian University,Yanji 133000,China |
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| Abstract: | Objective To research the suppression effect of immunosuppressive function in teeth allotransplantation,and find an effective therapic strategy of immune suppression.Methods All kinds of graft teeth transplan-tation activated immune rejection.Tregs was injected into murin tail vein.One weeks after the injection,the corneal teeth allograft tansplantation.Then the survival rates of transplanted teeth,the incidence rate of rejecton.Results After Tregs injection the corneal allograft rejection was delayed,and the survival time of grafts was prolonged.The mean survival time of Tregs injection group was(40.52±1.23)d(P<0.01).Conclusion The combined of Tregs prednisone scheme is effective therapeutic strategy to prevent rejection after teeth allotransplantation,in which the corneal allograft rejection is delayed and the allograft survival time is prolonged. |
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| Keywords: | Allograft tooth transplantation Immunological rejection Immunosuppression PBS |
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