婚前接种乙型肝炎疫苗阻断HBV母婴传播的效果观察

６年追踪随访婚前接种乙肝疫苗和对照组母亲的新生儿４２人，结果免疫成功母亲的婴儿６个月血清抗－ＨＢｓ阳性率为９０．００％（９／１０），且无１人感染ＨＢＶ，而两组婚前和婚后ＨＢｓＡｇ、ＨＢｓＡｇ／ＨＢｅＡｇ阳性母亲的婴儿依次为２０．００％（２／１０）及１８．１８％（４／２２），显著低于前者（Ｐ＜０．０１），但ＨＢｓＡｇ阳性率各为７０．００％（７／１０）、６８．１８％（１５／２２）。表明婚前乙肝疫苗免疫的“双阻断”作用可部分打破ＨＢＶ“夫妇－母婴－人群”的传播链。

Obeservation on Prevention of Hepatitis B Virus Transmission from Mother to Baby by Hepatitis B Vaccine

Forty-two new-born infants whose mothers had been given HBV vaccine before marriage were undergone medical examination for six years. The results showed that the six-month seroconversion rates of anti-HBs among those infants, whose mothers had been immunized successfully, were 90.00% (9/10), and no one was infected by HBV. But the rates of those infants whose mothers were found to be HBsAg(+) and HBsAg/HBeAg(+) before or after marriage were 20.00% (2/10) and 18.18% (4/22), respectively, being much lower than the former. The rates of HBsAg(+) were 70.00% (7/10) and 68.18% (15/22), respec-tively. This led to the conclusion that immunization with HBV vaccine before marriage will partly break the HBV transmission chain of "couples-mother and her baby-population".