Evaluation of some new heterocycles bearing 2-oxoquinolyl moiety as immunomodulator against highly pathogenic avian influenza virus (H5N8) |
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Authors: | Eman A E El-Helw Alaa R I Morsy Ahmed I Hashem |
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Affiliation: | 1. Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt;2. Central Laboratory for Evaluation of Veterinary Biologics (CLEVB), Agricultural Research Center, Cairo, Egypt |
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Abstract: | The hydrazide obtained from furan-2(3H)-one integrated with a quinolin-2(1H)-one core reported previously by our research group was utilized as a building block synthon to obtain some pyrrolone, pyridazinone, oxadiazole, and triazole derivatives through treating with some carbon electrophilic reagents, for example, chloroacetyl chloride, benzoyl chloride, acetic anhydride, carbon disulfide, 3,4-dimethoxybenzaldehyde, and 2-oxoquinolin-3-carbaldehyde to achieve the target heterocycles. The newly synthesized compounds were evaluated as immunomodulator against highly pathogenic avian influenza virus (H5N8). The compounds 1 , 11 , and 17 displayed the highest potency (100% protection). |
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