| 新型N-取代苯甲酰基-N′-(4-甲基苯并噻唑-2-基)硫脲衍生物的合成、晶体结构及抑菌活性 |
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| 引用本文： | 曾振芳,黄秋萍,韦友欢,黄秋婵,郑广进.新型N-取代苯甲酰基-N′-(4-甲基苯并噻唑-2-基)硫脲衍生物的合成、晶体结构及抑菌活性[J].分子科学学报,2017,33(4). |
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| 作者姓名： | 曾振芳 黄秋萍 韦友欢 黄秋婵 郑广进 |
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| 作者单位： | 广西民族师范学院化学与生物工程系,广西崇左532200;广西民族师范学院广西高校桂西南特色植物资源化学重点实验室培育基地,广西崇左532200 |
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| 基金项目： | 广西教育厅高校科研资助项目 |
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| 摘 要： | 以取代苯甲酸和2-氨基-4-甲基苯并噻唑为原料合成5个新型N-取代苯甲酰基-N′-(4-甲基苯并噻唑-2-基)硫脲衍生物,化合物结构经元素分析、IR、1 H NMR和13 C NMR表征,X-射线单晶衍射测定了N-(4-甲氧苯甲酰基)-N′-(4-甲基苯并噻唑-2-基)硫脲(化合物1)的晶体结构,该晶体为单斜晶系,P21/c空间群,选择广西主要经济作物中常见的病原菌,对目标化合物进行室内抑菌活性测试,实验结果发现该类化合物具有一定的抑菌活性.
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| 关 键 词： | 硫脲 合成 晶体结构 抑菌活性 |
Synthesis,crystal structure and antibacterial activity of new N-(substituted benzoyl)-N'-(4-methyl benzothiazole-2-base) thiourea derivatives |
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| ZENG Zhen-fang,HUANG Qiu-ping,WEI You-huan,HUANG Qiu-chan,ZHENG Guang-jin.Synthesis,crystal structure and antibacterial activity of new N-(substituted benzoyl)-N'-(4-methyl benzothiazole-2-base) thiourea derivatives[J].Journal of Molecular Science,2017,33(4). |
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| Authors: | ZENG Zhen-fang HUANG Qiu-ping WEI You-huan HUANG Qiu-chan ZHENG Guang-jin |
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| Abstract: | 5 new compounds N-(substituted benzoyl)-N'-(4-methyl benzothiazole-2-base) thiourea were synthesized from substituted benzoic acid and 4-methyl-2-benzothiazolamine.Their structures had been confirmed by elemental analysis,IR,1H NMR and 13C NMR.The crystal structure of the compound 1 was determined by X-ray diffraction analysis.Its crystal belongs to the triclinic system,space group P 21/c.We choose common pathogenic bacterias on the main economic crops in guangxi province to proceed antibacterial activity test.The result showed that the compounds exhibited certainly antibacterial activity. |
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| Keywords: | thiourea synthesis crystal structure antibacterial activity |
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