苯并噻唑-2-甲醛合成方法的改进

以邻氨基苯硫酚为原料,先与羟基乙酸反应合成2-羟甲基苯并噻唑,然后通过氧化反应生成苯并噻唑-2-甲醛。对比了几种氧化剂的效果,发现二氧化锰氧化的效果最好。优化的反应条件为,2-羟甲基苯并噻唑与二氧化锰的摩尔比为1∶8,回流反应8h,产率可达90.2%。该方法适合苯并噻唑-2-甲醛及其衍生物的大规模生产。

The Improvement of Synthesis of Benzothiazole-2-carbaldehyde

Condensation reaction of 2-aminothiophenol with glycolic acid provided benzothiazol-2-ylmethanol, after the oxidation of it, benzothiazole-2-formaldehyde was obtained. In the present study, by comparing the effects of several oxidants, manganese dioxide was selected as the appropriate agent for the oxidation reaction, and the influence of the feed ratio of the raw materials and the reaction time of reaction on the yield of the product were also studied. The optimum reaction conditions for oxidation reaction were obtained as follows: molar ratio of benzothiazol-2-ylmethanol to manganese dioxide was 1:8, reaction time was 8h, and the yield was up to 90.2%. The synthetic route is suitable for industrial production of the titled compound and its derivatives.