Non-enzymatic detection of hydrogen peroxide using a functionalized three-dimensional graphene electrode |
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| Affiliation: | 1. Department of Chemistry, Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Education Ministry, Zhejiang Sci-Tech University, Hangzhou, 310018, PR China;2. Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, 637457, Singapore;1. National Center for Materials Service Safety, University of Science and Technology Beijing, Xueyuan Road 30, 100083 Beijing, China;2. Shandong Special Equipment Inspection and Testing Group Co., Ltd, 250002 Jinan, China;3. Dipartimento di Chimica e Centro Interdipartimentale NIS (Nanostructured Surfaces and Interfaces), Università di Torino, Via Pietro Giuria 7, 10125 Torino, Italy;4. Institute of Micro and Nanomaterials, University of Ulm, Albert-Einstein-Allee 47, 89081 Ulm, Germany;1. Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei Key Laboratory of Polymer Materials, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, College of Chemistry & Chemical Engineering, Ministry of Education & Hubei Key Laboratory of Ferro & Piezoelectric Materials and Devices, Faculty of Physics & Electronic Science, Hubei University, Wuhan, 430062, PR China;2. Department of Environmental Sciences, Zhejiang Provincial Key Laboratory of Watershed Science and Health, Wenzhou Medical University, Wenzhou, 325035, PR China;3. School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning, 437100, PR China;1. State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China;2. Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310058, China;1. Faculty of Exact Science and Technology, Universidade Federal Da Grande Dourados, Dourados, MS 79825-070, Brazil;2. Department of Chemistry, The NanoCarbon Center, and Department of Materials Science and NanoEngineering, Rice University, 6100 Main Street, Houston, Texas 77005, United States;3. Institute of Physics, Universidade Federal Do Mato Grosso Do Sul, CP 549, 79070-900 Campo Grande, MS, Brazil;1. Center of Excellence for Advanced Material Research (CEAMR), King Abdulaziz University, 80203, Jeddah 21589, Saudi Arabia;2. Chemistry Department, Faculty of Science, King Abdulaziz University, 80203, Jeddah 21589, Saudi Arabia;3. Polymer Chemistry Laboratory 122, Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt;1. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 106, Taiwan, ROC;2. Graduate Institute of Biomedical and Biochemical Engineering, National Taipei University of Technology, Taipei, Taiwan, ROC |
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| Abstract: | A novel three-dimensional (3D) electrochemical sensor was developed for highly sensitive detection of hydrogen peroxide (H2O2). Monolithic and macroporous graphene foam grown by chemical vapor deposition (CVD) served as the electrode scaffold. Using in-situ polymerized polydopamine as the linker, the 3D electrode was functionalized with thionine molecules which can efficiently mediate the reduction of H2O2 at close proximity to the electrode surface. Such stable non-enzymatic sensor is able to detect H2O2 with a wide linear range (0.4 to 660 μM), high sensitivity (169.7 μA mM− 1), low detection limit (80 nM), and fast response (reaching 95% of the steady current within 3 s). Furthermore, this sensor was used for real-time detection of dynamic release of H2O2 from live cancer cells in response to a pro-inflammatory stimulant. |
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