| 1-[2′,4′-二氟-(1,1′-联苯)-4-基苯基甲基]-咪唑的合成 |
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| 引用本文： | 陈勇,高俊飞,邓健稳.1-[2′,4′-二氟-(1,1′-联苯)-4-基苯基甲基]-咪唑的合成[J].合成化学,2009,17(4). |
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| 作者姓名： | 陈勇 高俊飞 邓健稳 |
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| 作者单位： | 安阳师范学院,化学化工学院,河南,安阳,455002 |
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| 基金项目： | 河南省教育厅自然科学基础研究项目，河南省应用化学重点学科资助项目 |
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| 摘 要： | 以2,4-二氟联苯为起始原料,经酰化反应制得2′,4′-二氟-(1,1′-联苯)-4-基苯基甲酮(2);2经NaBH4还原得2′,4′-二氟-(1,1′-联苯)-4-基苯基甲醇(3);3经氯代得2′,4′-二氟-(1,1′-联苯)-4-基苯基氯甲烷(4);4与咪唑发生亲核取代反应合成了1-2′,4′-二氟-(1,1′-联苯)-4-基苯基甲基]-咪唑(5). 2～5为新化合物,其结构经1H NMR, IR, MS和元素分析确证.
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| 关 键 词： | 4-二氟联苯 咪唑 合成 |
Synthesis of 1-[2',4'-Difluorin-(1,1'-biphenyl)-4-ylphenylmethyl]-imidazole |
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| CHEN Yong,GAO Jun-fei,DENG Jian-wen.Synthesis of 1-[2'',4''-Difluorin-(1,1''-biphenyl)-4-ylphenylmethyl]-imidazole[J].Chinese Journal of Synthetic Chemistry,2009,17(4). |
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| Authors: | CHEN Yong GAO Jun-fei DENG Jian-wen |
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| Affiliation: | College of Chemistry & Chemical Engineering;Anyang Normal University;Anyang 455002;China |
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| Abstract: | 1-2',4'-Difluorin-(1,1'-biphenyl)-4-ylphenylmethyl]-imidazole(5)were synthesized by the reaction of acylation,reduction and substitute reaction from 2,4-difluorinbiphenyl.5 and key intermediate are novel compounds and their structures were confirmed by 1H NMR,IR,MS and elemental analysis. |
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| Keywords: | 2 |
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