二维超声联合超声造影TIC参数在乳腺导管内病变良/恶性诊断中的应用价值

本研究分析了二维超声(2DUS)联合超声造影(CEUS)时间-强度曲线(TIC)参数在乳腺导管内病变良/恶性鉴别诊断中的应用价值。选取乳腺导管内病变患者81例(共93个病变),均行2DUS及CEUS检查。结果显示,2DUS检出恶性病变17个,良性病变48个,诊断准确度69.89%(65/93)、敏感度53.13%(17/32)、特异度78.69%(48/61),阳性预测值为56.67%(17/30),阴性预测值为76.19%(48/63)。恶性病变达峰时间早于良性病变(P<0.05),峰值强度、曲线上升支斜率、曲线下面积均高于良性病变(P<0.05)。ROC曲线分析结果显示:2DUS联合CEUS-TIC参数鉴别诊断乳腺导管内病变良/恶性的AUC、敏感度、特异度均高于2DUS或CEUS单独检查(P<0.05)。因此可知,对于乳腺导管内病变,2DUS联合CEUS检查可明显提高对良/恶性的鉴别诊断效能。

Application Value of Two-dimensional Ultrasound Combined with Contrast-enhanced Ultrasound TIC Parameters in Diagnosis of Benign and Malignant Breast Intraductal Lesions

The application value of two-dimensional ultrasound(2DUS)combined with time-intensity curve(TIC)parameters of contrast-enhanced ultrasound(CEUS)in diagnosis of benign and malignant breast intraductal lesions were analyzed in this study.There were 81 patients with breast intraductal lesions(93 focus)who were examined by 2DUS and CEUS.The results showed that 48 benign lesions and 17 malignant lesions were detected by 2DUS.The diagnostic accuracy was 69.89%(65/93),sensitivity was 53.13%(17/32),specificity was 78.69%(48/61),positive predictive value was 56.67%(17/30),negative predictive value was 76.19%(48/63).The peak time of CEUS-TIC parameters of malignant lesions was earlier than that of benign lesions,and the peak intensity,slope of ascending branch and area under curve were higher than those of benign lesions(P<0.05).ROC curve analysis showed that the AUC,sensitivity and specificity of 2DUS combined with CEUS-TIC parameters in diagnosis of benign and malignant breast intraductal lesions were higher than those of single examination(P<0.05).It can be concluded that for breast intraductal lesions,2DUS combined with CEUS can significantly improve the diagnostic efficiency on benign and malignant tumor.