| 2,6-二氯二苯胺的新合成法 |
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| 引用本文： | 秦丙昌,陈静,朱文举,刘荣旺,许春霞.2,6-二氯二苯胺的新合成法[J].化学研究与应用,2009,21(7). |
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| 作者姓名： | 秦丙昌 陈静 朱文举 刘荣旺 许春霞 |
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| 作者单位： | 安阳师范学院化学化工学院,河南,安阳,455000 |
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| 基金项目： | 安阳市科技局资助项目 |
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| 摘 要： |
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| 关 键 词： | 2 6-二氯二苯胺 2 6-二氯苯氧乙酸甲酯 Smiles重排 |
New synthetic method for 2,6-dichlorodiphenylamine |
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| QIN Bing-chang,CHEN Jing,ZHU Wen-ju,LIU Rong-wang,XU Chun-xia.New synthetic method for 2,6-dichlorodiphenylamine[J].Chemical Research and Application,2009,21(7). |
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| Authors: | QIN Bing-chang CHEN Jing ZHU Wen-ju LIU Rong-wang XU Chun-xia |
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| Affiliation: | College of Chemistry and Chemical Engineering;Anyang Normal University;Anyang 455000;China |
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| Abstract: | A new method for synthesizing 2,6-dichlorodiphenylamine was presented in this article.2,6-dichlorodiphenylamine is the key intermediate for the preparing of diclofenac sodium.It was synthesized in a one-shot reaction with 2,6-dichlorophenol,a solution of sodium methoxide in methanol,methyl chloroacetate,aniline,and sodium hydroxide as raw materials by the acid-base neutralization,etherification,ammonolysis of ester,Smiles rearrangement of amide,and alcoholysis or hydrolysis of the rearrangement product.Based on many times of experiment,the best technological condition was found.The yield of target compound was about 91%. |
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| Keywords: | 2 6-dichlorodiphenylamine methyl 2 6-dichlorophenoxyacetate Smiles rearrangement |
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