| 体液中铝形态的HPLC分析 |
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| 引用本文： | 练鸿振,康玉芬,艾尔肯·牙森,毕树平,田笠卿.体液中铝形态的HPLC分析[J].分析科学学报,2004,20(4):421-425. |
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| 作者姓名： | 练鸿振 康玉芬 艾尔肯·牙森 毕树平 田笠卿 |
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| 作者单位： | 南京大学化学系;南京大学现代分析中心,南京,210093;南京大学化学系;南京大学现代分析中心,南京,210093 |
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| 基金项目： | 国家自然科学基金(No.20075011)，南京大学现代分析中心测试基金 |
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| 摘 要： | 体液中铝浓度的升高能够导致严重的神经性疾病如阿尔茨海默症和帕金森氏症等。铝的毒性及生物效应与其存在形式有关，因此迫切需要建立可靠的分析体液中实际铝形态的方法。近十年来各种分离模式的HPLC在这方面使用最多。实验证明，血清中的铝主要与转铁蛋白(Tf)以AlN-Tf和AlN-Tf-Fec的方式结合，而余下的部分则与柠檬酸(Citrate)、磷酸(Phosphate)形成Al-citrate，Al-phosphate和Al-citrate-phosphate。
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| 关 键 词： | 铝形态 体液 HPLC |
| 文章编号： | 1006-6144(2004)04-0421-05 |
| 修稿时间： | 2002年6月14日 |
HPLC Analysis of Aluminum Species in Biological Fluids |
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| LIAN Hong-Zhen.HPLC Analysis of Aluminum Species in Biological Fluids[J].Journal of Analytical Science,2004,20(4):421-425. |
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| Authors: | LIAN Hong-Zhen |
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| Affiliation: | LIAN Hong-Zhen~ |
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| Abstract: | Elevated Al concentration in biological fluids might cause serious neurotic diseases, e. g. Alzheimer's disease and Parkinson's dieases, etc. The toxicity of Al, as well as its biological effect, is associated with its forms. Reliable analytical procedures are urgently needed for detecting real Al species in biological fluids. The most commonly used method for the purpose is HPLC using a variety of separation modes. It has been demonstrated that the dominant Al species in serum is Al-transferrin (Tf) which is present both as Al_N-Tf and Al_N-Tf-Fec, the remaining Al corresponding to Al-citrate, Al-phosphate and ternary Al-citrate-phosphate. |
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| Keywords: | Aluminum species HPLC Biological fluid |
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