a Department of Chemical and Process Engineering, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU, UK
b Zeneca Pharamaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK
Abstract:
Radial basis function and feedforward neural networks are considered for modelling of the recombinant Escherichia coli fermentation process. The models use industrial on-line data from the process as input variables in order to estimate the concentrations of biomass and recombinant protein, normally only available from off-line laboratory analysis. The models performances are compared by prediction error and graphical fit using results obtained from a common testing set of fermentation data.