食管鳞癌IGF-1R、EGFR蛋白的表达及其临床意义

目的：研究IGF-1R、EGFR蛋白在食管鳞癌患者中的表达情况及其临床意义。方法应用免疫组织化学SP法检测50例食管鳞癌患者IGF-1R、EGFR蛋白的表达情况,取20例手术标本正常组织作为对照组。结果食管鳞癌中IGF-1R蛋白阳性表达率明显升高（χ2=28.29, P〈0.05）, EGFR蛋白阳性表达率明显升高（χ2=4.56, P〈0.05）。IGF-1R的阳性表达与食管癌的病理分级有关,分级越高阳性率越高,与浸润深度有关,侵及深肌层及外膜IGF-1R的表达明显高于侵及浅肌层及黏膜的表达,与TNM分期有关,分期越晚阳性率越高,差异均有统计学意义。淋巴结转移组IGF-1R或EGFR的表达明显高于非转移组。结论初步结果分析显示IGF-1R可能与食管鳞癌的病理分级及侵袭、转移有关, EGFR可能与食管鳞癌的转移有关。

Expression and significance of IGF-1R and EGFR protein in esophageal squamous carcinoma

Objective To investigate the expression of IGF Type 1 Receptor protein and EGFR protein in esophageal squamous carcinoma patients and its clinical significance. Methods The expressions of IGF-1R and EGFR protein were detected in 50 patients with esophageal squamous carcinoma, 20 cases of normal esophageal tissue by SP immunohistochemistry method. Results The positive rate of IGF-1R protein was markedly higher in esophageal squamous carcinoma than in normal esophageal tissue. （χ2=28.29, P=0.032）. The positive rate of EGFR protein was also higher. （χ2=4.56, P〈0.05）. Close correlation was found on the expression of IGF-1R between pathological grade of esophageal squamous carcinoma,the invasion of tumor and TNM stages. Difference was statistically significant. The expression of IGF-1R or EGFR was higher in lymph node metastasis positive patients than that in negative patients. Conclusion The expression of IGF-1R protein has some relationship with the pathological grade, invasion, metastasis and esophageal squamous carcinoma. The expression of IGF-1R protein has some relevance with the metastasis of esophageal squamous carcinoma.