| 抗乙型肝炎病毒基因治疗的若干进展 |
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| 引用本文： | 余永胜,陈有华.抗乙型肝炎病毒基因治疗的若干进展[J].金属学报,2002,7(6):574-576. |
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| 作者姓名： | 余永胜 陈有华 |
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| 作者单位： | 上海市第六人民医院传染科,上海 200233;1.皖南医学院弋矶山医院传染科,芜湖 241001 |
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| 摘 要： | 随着分子生物学特别是基因工程技术的发展,抗乙型肝炎病毒基因治疗有较深入的研究,利用基因重组、转基因及反义核酸等技术,在细胞水平或通过动物实验阶段的研究,基因有关治疗在抗乙肝病毒、抑制乙肝病毒复制中的作用已被证实。本文对转基因干扰素、DNA 疫苗(DNA 免疫)、反义寡核苷酸、三螺旋形成寡核苷酸(反基因寡核苷酸)、核酶有关抗乙型肝炎病毒基因治疗的研究进行综述。
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| 关 键 词： | 乙型肝炎转基因干扰素 DNA疫苗 反义寡核苷酸 三螺旋形成寡核苷酸 核酶 |
| 收稿时间： | 2001-07-25 |
| 修稿时间： | 2001-08-08 |
Recent advances in genetic therapy for anti-hepatitis B virus |
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| YU Yong-Sheng,CHEN You-Hua.Recent advances in genetic therapy for anti-hepatitis B virus[J].Acta Metallurgica Sinica,2002,7(6):574-576. |
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| Authors: | YU Yong-Sheng CHEN You-Hua |
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| Affiliation: | Shanghai Sixth People' s Hospital,Shanghai 200233;1.Department of Infectious Diseases,Affliated Yijishan Hospital,Wannan Medcal College,Wuhu 241001 |
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| Abstract: | With the development of molecular biology,especially gene engineering technique,genetic therapy for anti-hepatitis B virus was deeply researched.Employing techniques of gene recombinant,transgene,and anti-sense nucleic acid etc,the function of genetic therapy for anti-hepatitis B virus was verified in cellular level or through animal experiment.In this article,studies on gene trangenically IFN,DNA vaccine(DNA immunization),antisense oligodeoxynucleotide(ONas),triple helix forming oligodeoxynucleotide(TFO),anti-gene oligodeoxynucleotide(ONan),ribozyme were reviewed. |
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| Keywords: | heptitis B gene trangenically IFN DNA vaccine antisense oligodeoxynucleotide(ONas) triple helix forming oligodeoxynucleotide(TFO) ribozyme |
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