Preparation of lung targeting microspheres of gelatin ceftiofur alkali |
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Authors: | Zhihui Hao Yongda Zhao Baohan Qu Haoting Wu Lihua Hao Zhaopeng Ding Fenfang Yang |
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Affiliation: | 1703. Laboratory of Chemical and Biological, College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao, 266109, China 2703. Qingdao Continent Pharmaceutical Co. Ltd., Qingdao, 266061, China 3703. China Institute of Veterinary Drug Control, Beijing, 100081, China
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Abstract: | Gelatin ceftiofur alkali microsphere was prepared to observe its characteristics and evaluate preservation conditions. The glutaraldehyde was increased and the carboxylic methyl chitosan was added to improve the microsphere. The experimental results show microspheres have a better morphology surface and fairly regular structure with 4% glutaraldehyde. The average particle size is 15.84 μm and particle size distribution is narrow which shows a good uniformity. Microsphere size was affected by the stirrer speed, dosing ratio and curing degree. The greater drug loaded is, the better microspheres loading is; but with the increase of drug loading rate, the entrapment efficiency increases first and then decreases. The drug release rate of the microsphere is 24.90% in 0.5 h and 84.90% in 48 h, when CMC-GMs with 4% curing agent is 32.03% in 0.5 h and 88.44% in 48 h. So Gms embedding of ceftiofur alkali are better than CMC-GM. The stability tests show that strong light, high temperature, high humidity have a great influence on the microspheres. |
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