盐酸坦洛新缓释片治疗输尿管下段结石的临床研究

目的:评价选择性α1肾上腺受体阻滞剂(盐酸坦络新缓释片)在治疗单侧输尿管末端结石中的临床效果。方法:72例单侧输尿管末端结石的患者随机分为两组进行药物治疗,两组间的年龄、性别、结石大小在统计学上无显著性差异。对照组(n=36)服用排石颗粒(5 g,3/d),治疗组(n=36)服用排石颗粒(5 g,3/d)和盐酸坦络新缓释片(0.4 mg,1/d),共服药两周,并对所有患者随访4周,通过询问症状和检查尿常规、B超,了解疼痛缓解时间和程度,排石率、排石时间,并观察不良反应。结果:治疗组排石率86.1%(31/36),对照组排石率33.3%(12/36)P<0.01,治疗组与对照组在结石排出时间分别为(6.8±2.0)d和(12.0±1.8)d,P<0.05,两组患者均未出现明显不良反应。结论:盐酸坦络新缓释片有明显促进输尿管下段结石排出的作用。

Treatment of distal ureteral calculi with tamsulosin

Objective:To evaluate the clinical efficacy of tamsulosin,a selective blocker of α1adrenoceptors,in the treatment of distal ureteral calculi.Methods: A total of 72 patients with symptomatic ureteral calculi were randomly divided into two groups.There was no significant differences between the two groups for the patient age,gender distribution and mean stone size.The treatment group(n= 36) received Paishi grains(5 g,3 times/day) plus tamsulosin(0.4 mg/ daily) for two weeks,and the control group(n= 36) received only Paishi grains.The patients were followed up for 4 weeks.Results: The lithagogue rate of the treatment group was 86.1%(31 of 36),while the control group was only 33.3%(12 of 36)(P< 0.01).There was significant difference between the two groups in the days of removing urinary calculus(6.8±2.0 vs 12.0±1.8)(P<0.05).No serious complication was observed.Conclusion: Tamsulosin has obvious improving effect in the treatment of distal ureter stone.