| Agrin在神经系统损伤后修复中的作用 |
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| 引用本文： | 杨利强,张彭跃. Agrin在神经系统损伤后修复中的作用[J]. 中国病理生理杂志, 2016, 32(6): 1142-1146. DOI: 10.3969/j.issn.1000-4718.2016.06.031 |
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| 作者姓名： | 杨利强 张彭跃 |
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| 作者单位： | 昆明理工大学医学院, 云南 昆明 650500 |
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| 基金项目： | 国家自然科学基金资助项目(No.81460351) |
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| 摘 要： | 正神经系统主要由中枢神经系统(central nervous system,CNS)和周围神经系统(peripheral nervous systems,PNS)两大部分组成。CNS损伤包括脊髓损伤和脑神经损伤,主要以后者为主,具有发病率高、致残率高和死亡率高的特点。此外,CNS损伤后会引起包括DNA降解和细胞膜磷脂酰丝氨酸残基早期暴露在内的一系列程序性细胞死亡的病理过程,进
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| 关 键 词： | 聚集蛋白 神经系统损伤 突触再生 |
| 收稿时间： | 2015-12-14 |
Role of agrin in repair of nervous system injury |
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| YANG Li-qiang,ZHANG Peng-yue. Role of agrin in repair of nervous system injury[J]. Chinese Journal of Pathophysiology, 2016, 32(6): 1142-1146. DOI: 10.3969/j.issn.1000-4718.2016.06.031 |
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| Authors: | YANG Li-qiang ZHANG Peng-yue |
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| Affiliation: | Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China |
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| Abstract: | Agrin plays an important role in the development, occurrence and stability of the neuromuscular junction. It also plays an indispensable role in the central nervous system. In the repair process of the nervous system injury, agrin maintains the integrity of the blood-brain barrier, promotes synaptic regeneration of damaged areas, and improves the injured neural networks, which contributes to brain area remodeling and neurological function recovery. In this paper, we briefly review the role and possible mechanism of agrin in nervous system damage and repair process |
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| Keywords: | Agrin Nervous system damage Synaptic regeneration |
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