| 超临界二氧化碳中药物控制释放体系的一步法制备研究 |
| |
| 引用本文： | 曹丽琴,王成卫,陈六平.超临界二氧化碳中药物控制释放体系的一步法制备研究[J].中国化学,2009,27(2):267-272. |
| |
| 作者姓名： | 曹丽琴 王成卫 陈六平 |
| |
| 作者单位： | 1中山大学化学与化学工程学院, 广东广州 510275 ;2新疆大学石油天然气精细化工教育部重点实验室, 新疆乌鲁木齐 830046 ; |
| |
| 摘 要： | 用一步法首次制备了以N-异丙基丙烯酰胺类共聚物为基料的药物释放体系。在此法中，超临界二氧化碳同时作为聚合介质和渗透试剂。制得的聚合物微球用扫描电镜、差示扫描量热仪、透射电镜、X射线衍射仪等进行了表征，并用体外释放模拟考察了原位法制备的微凝胶对渗入的目标药物布洛芬的释放效果。
|
| 关 键 词： | 超临界二氧化碳 控制释放 N-异丙基丙烯酰胺-N-乙烯基吡咯烷酮共聚物 一步法 |
| 收稿时间： | 2008-4-25 |
| 修稿时间： | 2008-8-15 |
One Step Preparation of Controlled Drug Release Systems in Supercritical Carbon Dioxide |
| |
| Liqin CAO,Chengwei WANG,Liuping CHEN.One Step Preparation of Controlled Drug Release Systems in Supercritical Carbon Dioxide[J].Chinese Journal of Chemistry,2009,27(2):267-272. |
| |
| Authors: | Liqin CAO Chengwei WANG Liuping CHEN |
| |
| Affiliation: | 1. School of Chemistry and Chemical Engineering, Sun Yat‐sen University, Guangzhou, Guangdong 510275, China;2. Key Laboratory of Oil and Gas Fine Chemicals of the Ministry of Education, Xinjiang University, Urumqi, Xinjiang 830046, China;3. Tel.:0086‐020‐84115559;4. Fax: 0086‐020‐84112245 |
| |
| Abstract: | Drug delivery systems based on copolymers of N‐isopropylacrylamide were first prepared by a one step method, in which supercritical carbon dioxide was simultaneously used as a polymerization medium and an impregnation agent. The obtained microspheres were characterized by scanning electronic microscopy (SEM), differential scanning calorimetry (DSC), transmission electron microscopy (TEM) and X‐ray diffraction (XRD). The release effect of the in situ prepared microgels impregnated with ibuprofen was presented through in vitro release simulation. |
| |
| Keywords: | supercritical carbon dioxide controlled release poly(N‐isopropylacrylamide‐co‐N‐vinyl‐pyrrolidone) (poly(NIPA‐co‐VP)) one step preparation |
|
| 点击此处可从《中国化学》浏览原始摘要信息 |
|
点击此处可从《中国化学》下载全文 |
