长期小剂量红霉素口服治疗慢性支气管炎的疗效观察

目的观察长期小剂量应用红霉素类抗生素治疗慢性支气管炎的I晦床疗效，总结其临床价值。方法选取本院2008年12月～2010年12月140例慢性支气管炎患者，随机分为观察组和对照组各70例，对照组根据患者临床症状予抗感染及止咳、祛痰，解痉、平喘等对症治疗及增强免疫治疗，观察组在对照组的治疗基础上加用小剂量红霉素250mg／d，长期口服，两组均临床观察1年，对比两组治疗效果，记录相关数据并进行统计学分析。结果观察组显效56例，占80．00％，有效12例，占17．14％，无效2例，占2．86％，急性发作住院1次，总有效率97．14％；对照组显效37例，占52．86％，有效16例，占22．86％，无效17例，占24．29％，急性发作住院6次，总有效率75．71％，两组疗效比较差异有统计学意义（P〈0．05）。观察组发生不良反应3例，占4．29％，对照组发生不良反应2例，占2．86％，两组不良反应发生率比较差异无统计学意义（P〉0．05）。结论长期小剂量应用红霉素口服治疗慢性支气管炎的临床疗效明显优于常规抗感染及对症治疗，且明显减少急性发作住院次数，不良反应较少，值得在临床上推广应用。

Long - term low - dose oral erythromycin treatment efficacy of chronic bronchitis

Objective To observe the long - term low - dose application of erythromycin antibioties＇s clinical efficacy for the treatment of chronic bronchitis, summarize its clinical divided into two groups and 70 cases of the control group, the sistanee to infection and cough phlegm, the solution spasm value. Methods 140 cases of chronic bronchitis were randomly control group according to clinical symptoms in patients with reasthma and other symptomatic treatment and enhanced the immune treatment, observation group was treated based on the use of low - dose erythromycin 250mg/d, long - term oral, clinical observation in both groups a year, compared two groups of treatment effect observed, recorded relevant data for statistical analysis, Results The markedly effective in 56 cases, accounting for 80.00%, effective in 12 cases, accounting for 17. 14%, 2 cases, accounting for 2. 86%, acute hospital 1, the total effective rate 97. 14% ; the control group that were 37 cases, accounting for 52. 86%, effective in 16 cases, accounting for 22. 86%, ineffective in 17 cases, accounting for 24. 29%, acute hospital six times, the total effective rate 75.71%, difference between the two groups was significant （P 〈 0. 05）, with statistical significance. Group of adverse reactions observed in 3 cases, accounting for 4.29% in the control group had adverse reactions in 2 cases, accounting for 2. 86%, the incidence of adverse reactions compared two groups, no significant difference （ P 〉 0.05 ）. Conclusion Long - term low - dose oral erythromycin treatment of chronic bronchitis application of clinical efficacy is superior to conventional anti - infective and symptomatic treatment, and significantly reduced the number of acute hospital stay, and fewer adverse reactions, it is reasonable in the clinical application.