克林霉素预防术后感染98例的安全性调查

目的:了解克林霉素注射剂在预防术后感染中的安全性。方法:采用填写调查表和面访相结合的方式对我院应用克林霉素注射剂作术后预防用药的住院病人进行调查分析。结果:克林霉素预防术后感染98例,其中单用克林霉素51例(感染控制率100%),联用其他抗菌药物47例,共发生不良反应7例,主要为恶心、呕吐、腹泻、粒细胞减少、转氨酶升高等。结论:克林霉素可以用于术后感染的预防,应用时要注意剂量不宜过大,尽量采用单独用药,以避免或减少不良反应,增加用药的安全性。

Investigation on the safety of clindamycin for prevention of postoperative infection in 98 cases

Objective: To evaluate the safety of clindamycin injection for prevention of postopevative infection. Methods: By way of questionnaire and interview, the patients receiving clindamycin injection for prevention of postoperative infection were investigated and analysed. Results: 98 inpatients were involved in the study of clindamycin for prevention of postoperative infection, 51 cases of them used clindamycin alone(infection control rate 100%), and 47 cases of them used clidamycin in combination with other drugs, 7 cases occured adverse drug reactions, mainly nausea, vomiting, diarrhea, granulocytopenia and increased transaminases. Conclusion: Clindamycin can prevent the postoperative infections when used alone and in regular doses.