Genetic manipulation of carotenoid biosynthesis: strategies, problems and achievements |
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| Authors: | Sandmann G |
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| Affiliation: | 1. Vicomtech-IK4 Research Centre, Mikeletegi Pasealekua 57, 20009 San Sebastian, Spain;2. Biodonostia Health Research Institute, eHealth Group, Bioengineering Area, P. Doctor Begiristain s/n, 20014 San Sebastian, Spain;3. University of the Basque Country UPV/EHU, Computational Intelligence Group, Computer Science Faculty, P. Manuel Lardizabal 1, 20018 San Sebastian, Spain;4. School of Engineering, Faculty of Engineering and Built Environment, The University of Newcastle, University Drive, Callaghan NSW 2308, Australia;5. Gdansk University of Technology, Narutowicza 11/12, 80-952 Gdansk, Poland;6. Bilbomatica, C/ Santiago de Compostela 12 4 A, 48003 Bilbao, Spain;7. ERESA SA, Avda. de Campanar 114 bajo, 46015 Valencia, Spain;8. Valencia General University Hospital, Avenida Tres Cruces 2, 46014 Valencia, Spain;1. Portland, OR, USA;1. Molecular Phytobacteriology Laboratory, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, South Korea;2. Biosystems and Bioengineering Program, University of Science and Technology, Daejeon 34141, South Korea;1. Key Laboratory of Horticultural Plant Biology (Ministry of Education), Huazhong Agricultural University, Wuhan, China;2. School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK;3. Department of Plant Science and Landscape Architecture, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, USA;1. Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (Northeast Region), Ministry of Agriculture, Harbin, Heilongjiang Province, 150030, China;2. Horticulture and Landscape Architecture of Northeast Agricultural University, No. 59 Mucai Street, Harbin, Heilongjiang Province, 150030, China;3. Hainan Base of Heilongjiang Agriculture Academy, Sanya, Hainan, 572000, China;1. Department of Molecular and Cell Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran;2. Department of Biotechnology, Akal College of Agriculture, Eternal University, Baru Sahib, Sirmour, India;3. Gopi Nath P.G. College, VBSP University, Deoli-Salamatpur, Ghazipur, Uttar Pradesh, India |
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| Abstract: | Carotenoids, some of which are provitamin A, have a range of diverse biological functions and actions, especially in relation to human health. For example, carotenoids are known to be crucial for normal vision and have been associated with reducing the risk of several degenerative diseases including cancer. The putative advantage of modifying and engineering the carotenoid biosynthetic pathways is obvious: to provide sources for the isolation of desired carotenoids or to generate food plants with increased carotenoid content. This article reviews the studies of carotenoid production in heterologous microorganisms and the engineering of crop plants using manipulated carotenoid biosynthesis. |
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