Calories,fat and cancer |
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Authors: | David Kritchevsky Maxine M Weber Carrie L Buck David M Klurfeld |
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Affiliation: | (1) The Wistar Institute of Anatomy and Biology, 36th St. at Spruce, 19104 Philadelphia, PA |
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Abstract: | The experiments reported are part of our effort to dissociate the tumor-enhancing effects of dietary fat and high caloric
intake. Rats either were fed ad libitum diets containing 4% corn oil or their calories were restricted by 40% and their diets
contained 13.1% corn oil. Incidence of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors was 80% in rats fed ad
libitum and 20% in those fed the calorie-restricted diets. Incidence of 1,2-dimethylhydrazine (DMH)-induced colon tumors was
100% in rats fed ad libitum and 53% in those whose caloric intake was restricted by 40%. The tumor yield (tumors per tumor-bearing
rat) was significantly lower in rats on caloric restriction. In another series, rats were fed diets containing 5, 15 or 20%
corn oil ad libitum or were fed calorie-restricted (by 25%) diets which provided 20 or 26.6% corn oil (therefore, the same
absolute amount of fat was consumed in each of the pair-fed groups). Tumor incidence and tumor yield in the two calorie-restricted
groups were similar to those seen in the rats fed 5% fat ad lititum; tumor burden (total g of tumor) was 45–65% lower in the
calorie-restricted rats. The data suggest that caloric intake is a more stringent determinant of tumor growth than fat intake. |
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