麝黄膏脐敷治疗肝硬化难治性腹水临床研究

目的 :观察麝黄膏治疗肝硬化难治性腹水的疗效。方法 :选择肝硬化难治性腹水住院患者 ,治疗组 (32例 )采用基础治疗 +麝黄膏脐敷 ,对照组 (2 7例 )采用基础治疗 (包括保肝药物 ,利尿剂 ,白蛋白 ,抗生素等 )。观察治疗前后患者的体重、2 4 h尿量和尿电解质、肝功能以及血清一氧化氮 (NO)含量。彩色多普勒测量门脉血流量。结果 :治疗组总有效率为 84 .0 % ,对照组总有效率为 4 9.1%。治疗组治疗后体重、腹围明显下降、肝功能明显改善 ,2 4h的尿量增多。治疗组 NO含量、门脉血流量明显下降 (P <0 .0 5 ) ,而对照组无明显改善 (P >0 .0 5 )。结论 :麝黄膏脐敷对肝硬化难治性腹水有明显的治疗作用 ,比单纯基础治疗疗效高。

Clinical Study of Shehuang Paste Paved on the Umbilicus in the Treatment of Refractory Ascites due to Cirrhosis

Objective:To observe the curative effect of the Chinese medicine Shehuang-paste in the treatment of refractory cirrhosis ascites.Methods: 59 inpatients with refractory cirrhosis ascites were selected. 32 cases of the treatment group were treated with basal therapy and the Shehuang-paste, while 27 cases of the control group were treated with basal therapy (including liver-protecting drugs, diuretics, albumin, antibiotics, etc). The weight, 24 hours urinary output, urine electrolyte, liver function before and after the treatment were observed. The NO content of the blood serum was detected with the colorimetry. The portal vein blood flow was measured with color Doppler.Results:The total effective rate of the treatment group and control group was 84.0%, 51.9% respectively. The weight and abdomen circumference of the treatment group obviously decreased, while 24 hours urinary output increased, the liver function was improved, and the diameter of the portal vein trunk and blood flow reduced. There was significant difference between the treatment group and the control group (P<0.05). The NO content and the blood flow of the portal vein of the treatment group before and after the treatment decreased (P<0.05), while those of the control group were not obviously improved (P>0.05).Conclusion:The Shehuang-paste paved on the umbilicus had remarkable effect on the refractory cirrhosis ascites, which was better than that of the simply basal treatment.