清胃汤治疗慢性浅表性胃炎临床研究

目的：观察清胃汤治疗慢性浅表性胃炎脾胃湿热证的临床疗效。方法：将80例慢性浅表性胃炎脾胃湿热证患者随机分为对照组和治疗组,每组各40例。对照组给予奥美拉唑肠溶片及马来酸曲美布汀片口服,幽门螺杆菌（Hp）阳性者加服克拉霉素分散片及阿莫西林胶囊;治疗组口服清胃汤,疗程均为4周。观察治疗后两组患者胃镜检查情况、中医证候积分、临床症状改善情况及幽门螺杆菌（Hp）清除率,随访复发率。结果：治疗组胃黏膜疗效评定的有效率为95%,优于对照组的80%（P〈0.05）;胃黏膜组织学疗效评定的有效率为90%,优于对照组的75%（P〈0.05）;治疗组中医证候疗效的有效率为97.5%,优于对照组的72.5%（P〈0.05）;治疗后治疗组脾胃湿热证积分为（5.28±1.97）分,低于对照组的（8.95±3.26）分（P〈0.05）,治疗组餐后饱胀不适、早饱感和上腹部疼痛等主要症状改善明显,有效率分别为96.77%、100.00%、97.14%,对照组分别为78.13%、83.33%、82.35%,差异均具有统计学意义（P〈0.05）;治疗组Hp清除率为57.14%,对照组为60.00%,两组Hp清除率比较,差异无统计学意义（P〉0.05）;治疗组复发率为30.43%,低于对照组的56.26%（P〈0.05）。结论：清胃汤治疗慢性浅表性胃炎脾胃湿热证临床疗效好,并能杀灭Hp,降低复发率,不良反应少。

Clinical Study on Chronic Superficial Gastritis Treated with Qingwei Decoction

Objective： To observe the clinical curative effect of Qingwei Decoction in the treatment of chronic superficial gastritis of spleen-stomach damp heat syndrome. Methods： 80 cases of chronic superficial gastritis were randomly divided into the treatment group and the control group,40 cases in each group. The control group was given omeprazole enteric coated tablets and trimebutine maleate tablets,Helicobacter pylori（ Hp） positive addition clarithromycin dispersible tablets and amoxicillin capsule,and the treatment group was treated with Qingwei Decoction. 4 weeks as one course of treatment. And gastroscopy results,TCM syndrome integral,clinical symptoms and Hp clearance rate and recurrence rate of the two groups of patients were observed after treatment. Results： Efficiency of curative effect evaluation of gastric mucosa of the treatment group is 95%,better than the control group of 80%（ P〈0. 05）; Gastric mucosal histology evaluation curative effect rate was 90%,better than the control group of 75%（ P〈0. 05）; TCM syndrome curative effect rate of the treatment group was 97. 5%,better than the control group of 72. 5%（ P〈0. 05）; After treatment,spleen-stomach damp heat syndrome is the integral of（ 5. 28 ± 1. 97）,lower than that of the control group（ 8. 95 ± 3. 26）（ P〈0. 05）. Postprandial fullness discomfort,early satiety,epigastric pain and other major symptoms improved significantly in the treatment group,the effective rate were 96. 77%,100. 00%,97. 14%,and the control group 78. 13%,83. 33%,82. 35%,the difference was statistically significant（ P〈0. 05）; Hp removal rate was 57. 14% in the treatment group and the control group 60%,and there was no statistically significant difference（ P〈0. 05）; Recurrence rate of the treatment group was 30. 43%,lower than that in control group 56. 26%（ P〈0. 05）. Conclusion： Qingwei Decoction in the treatment of spleen-stomach damp heat syndrome of chronic superficial gastritis has good clinical curative effect,which can ki