| 限制性液体复苏产兔失血性休克对肠缺血再灌注损伤的保护作用 |
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| 作者姓名： | Huang LP Yu YH Sheng C Gong SP |
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| 作者单位： | 南方医科大学南方医院妇产科,广东广州,510515 |
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| 基金项目： | 国家自然科学基金(30840089); 南方医院新业务新技术(20009008)~~ |
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| 摘 要： | 目的应用产兔非控制性失血性休克模型,探讨限制性液体复苏对产兔肠缺血再灌注损伤的保护作用。方法 24只产后6 h的新西兰大白兔被随机分成4组,假休克组(P组)、休克未处理组(P0组)、传统液体复苏组(PNL组)、限制性液体复苏组(PLH组),建立未控制重度失血性休克模型,分别于休克30 min后接受不同的液体复苏方案,于休克后90 min接受手术止血和输血输液治疗。在实验结束后处死产兔,观察不同液体复苏方式对小肠组织超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量及肠粘膜形态损伤等情况。结果失血性休克时缺血再灌注损伤导致肠粘膜损伤加重、肠组织SOD活性降低及MDA含量上升,限制性输液能显著改善上述改变。结论限制性液体复苏较充分快速液体复苏显著缓解了肠组织缺血再灌注损伤。
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| 关 键 词： | 限制性液体复苏 非控制性失血性休克 缺血再灌注损伤 小肠粘膜 |
Protective effect of limited fluid resuscitation against intestinal ischemia-reperfusion injury in postpartum rabbits with uncontrolled hemorrhagic shock |
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| Huang LP,Yu YH,Sheng C,Gong SP.Protective effect of limited fluid resuscitation against intestinal ischemia-reperfusion injury in postpartum rabbits with uncontrolled hemorrhagic shock[J].Journal of Southern Medical University,2011,31(9):1530-1533. |
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| Authors: | Huang Li-ping Yu Yan-hong Sheng Chao Gong Shi-peng |
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| Affiliation: | HUANG Li-ping,YU Yan-hong,SHENG Chao,GONG Shi-peng Department of Gynecolocy and Obstetrics,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China |
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| Abstract: | Objective To investigate the protective effect of limited fluid resuscitation against intestinal ischemia-reperfusion injury in postpartum rabbits with severe uncontrolled obstetrical hemorrhagic shock.Methods Twenty-four postpartum rabbits were randomly assigned into sham shock group(group P),shock group without interventions(group P0),conventional fluid resuscitation group(group PNL),and limited fluid resuscitation group(group PLH),and the model of severe uncontrolled hemorrhagic shock was established in ... |
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| Keywords: | limited fluid resuscitation hemorrhagic shock ischemia-reperfusion injury intestine mucosa |
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