| 肿瘤浸润性树突状细胞在子宫内膜癌中的凋亡及其Fas、FasL表达意义 |
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| 作者姓名： | Jia JJ Wang ZN Liu GX Wang ZX |
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| 作者单位： | 1. 暨南大学附属第一医院妇产科,广东广州,510632
2. 暨南大学医学院血液病研究所,广东广州,510632 |
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| 基金项目： | 国家自然科学基金(30670902); 广东省医学科学技术研究基金(A2009361)~~ |
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| 摘 要： | 目的探讨子宫内膜癌浸润性树突状细胞(TIDC)凋亡及其凋亡相关蛋白Fas/FasL的表达意义。方法利用S-100单克隆抗体和DNA缺口末端标记(TUNEL法)相结合,分析45例子宫内膜癌组织中TIDC凋亡状况;通过免疫组织化学双重染色方法检测TIDC表面Fas/FasL分子表达。结果子宫内膜癌组织中TIDC凋亡发生率显著高于子宫内膜组织中树突状细胞凋亡发生率(13.02±0.64)%vs(6.82±0.53)%,P<0.05];子宫内膜癌组织TIDC膜表面Fas表达显著低于正常子宫内膜组织(7.88±1.05 vs 19.25±3.03,P<0.05),子宫内膜癌组织TIDC膜表面FasL表达显著高于正常子宫内膜组织(12.95±2.25 vs 7.51±1.14,P<0.05)。结论子宫内膜癌组织中TIDC凋亡增加及Fas、FasL在TIDC上表达失衡,可能导致子宫内膜癌免疫逃逸发生。
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| 关 键 词： | 子宫内膜癌 肿瘤浸润性树突状细胞 凋亡 Fas FasL |
Apoptosis and expression of Fas/FasL in tumor infiltrating dendritic cells in human endometrioid adenocarcinoma |
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| Jia JJ,Wang ZN,Liu GX,Wang ZX.Apoptosis and expression of Fas/FasL in tumor infiltrating dendritic cells in human endometrioid adenocarcinoma[J].Journal of Southern Medical University,2011,31(10):1693-1696. |
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| Authors: | Jia Jian-jun Wang Zi-neng Liu Ge-xiu Wang Zhi-xin |
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| Affiliation: | JIA Jian-jun1,WANG Zi-neng1,LIU Ge-xiu2,WANG Zhi-xin1 1Department of Obstetrics and Gynecology,First Affiliated Hospital,2Institute of Hematology,Jinan University,Guangzhou 510632,China |
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| Abstract: | Objective To investigate apoptosis of tumor infiltrating dendritic cells(TIDC) and their expression of Fas/FasL(CD95/CD95L) in human endometrioid adenocarcinoma.Methods The apoptotic rate of TIDC was measured in 45 cases of endometrioid adenocarcinoma and 20 cases of normal endometrium tissues(control) by double-label immunohistochemistry using the monoclonal antibody S-100 protein and TUNEL technique.The expressions of Fas and FasL in TIDCs were detected using double-label immunohistochemistry and imaging ... |
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| Keywords: | endometrioid adenocarcinoma tumor infiltrating dendritic cell apoptosis Fas FasL |
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